Subject(s)
Carotid Artery Diseases/diagnosis , Postoperative Complications/diagnosis , Respiratory Tract Fistula/diagnosis , Tracheal Diseases/diagnosis , Tracheostomy/adverse effects , Vascular Fistula/diagnosis , Carotid Artery Diseases/etiology , Female , Humans , Respiratory Tract Fistula/etiology , Tracheal Diseases/etiology , Vascular Fistula/etiology , Young AdultABSTRACT
BACKGROUND: Parathyroid carcinoma is a rare neoplasm representing <1% of primary hyperparathyroidism cases. It is often not diagnosed until surgical exploration as a preoperative diagnosis is often not possible. Thus, preoperative staging for most patients is not feasible and this may compromise the treatment strategy. METHODS AND RESULTS: We report a case of a 29-year-old man presenting with avulsion fracture of the right elbow after a trivial fall. Neck exploration revealed an enlarged left lobe focally adherent to the larynx and trachea. Final pathology revealed parathyroid carcinoma with focally positive margin at the site of tracheal invasion. CONCLUSION: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. The etiology of parathyroid carcinoma is usually obscured, and the initial operation offers the best chance for cure.
Subject(s)
Elbow Injuries , Fractures, Spontaneous/etiology , Parathyroid Neoplasms/complications , Parathyroid Neoplasms/diagnosis , Accidental Falls , Adult , Biopsy, Needle , Diagnosis, Differential , Follow-Up Studies , Fractures, Spontaneous/diagnosis , Fractures, Spontaneous/surgery , Humans , Immunohistochemistry , Magnetic Resonance Imaging/methods , Male , Parathyroid Neoplasms/surgery , Parathyroidectomy/methods , Treatment OutcomeABSTRACT
Radiation therapy to the head and neck for the treatment of benign diseases carries the potential for the late development of carcinoma. Low-dose radiation has been used as an adjunctive treatment for recurrent keloids, especially massive keloids, but the carcinogenic potential of ionizing radiation in this setting remains controversial. We report the case of a 37-year-old black woman with a history of severe earlobe keloids who had been first treated with resection and postoperative radiation at the age of 9 years. When she had reached the age of 36 years, she required reoperation for massive keloid scarring, after which she underwent a second course of postoperative radiation to the right side of her face and neck. Some 20 months after the second administration of radiation therapy, she developed a mucoepidermoid carcinoma in the right parotid gland. The tumor was successfully treated with surgery.
