ABSTRACT
We present a case of malakoplakia presenting as a lesion in the oropharynx of an elderly smoker. In this case a clinical diagnosis of carcinoma of the pharynx was made, biopsy revealed the nature of the lesion and management was radically altered.
Subject(s)
Malacoplakia/pathology , Oropharynx/pathology , Pharyngeal Diseases/pathology , Aged , Diagnosis, Differential , Humans , Male , Oropharyngeal Neoplasms/diagnosisABSTRACT
Immunohistochemistry was used to examine 10 cases of malignant fibrous histiocytoma. Malignant cells in all cases expressed vimentin and in eight there was co-expression of either desmin or neurofilament, both of these being present in four cases. In addition, cytokeratin was found in one case. In each tumour, a population of small cells was identified which had the staining characteristics of benign macrophages, and this was distinct from the tumour cells. This study supports the concept that malignant fibrous histiocytoma is a tumour of mesenchymal cells rather than of histiocytes and emphasizes the diversity of its cytostructure.
Subject(s)
Histiocytoma, Benign Fibrous/pathology , Antibodies, Monoclonal/immunology , Desmin/metabolism , Histiocytoma, Benign Fibrous/metabolism , Histocytochemistry , Humans , Immunochemistry , Intermediate Filaments/immunology , Keratins/metabolism , Macrophages/metabolism , Vimentin/metabolismABSTRACT
It is shown that there is a substantial and sustained disparity, both on a national and on a regional basis, between the numbers of males and the numbers of females in care. The disparity is analysed by examining the reasons for entering care, and the legal status of those in care. It is shown that in the aggregate the disparity is caused by imbalances in admissions, particularly in certain key legal and administrative categories. The phenomenon is also shown to have both geographical and accommodation dimensions, and some conjectures for its behavioural origins are offered.
Subject(s)
Child Welfare , Foster Home Care , Residential Facilities , Sex Ratio , Adolescent , Child , Child Welfare/legislation & jurisprudence , Child, Preschool , England , Family , Female , Foster Home Care/legislation & jurisprudence , Humans , Infant , Infant, Newborn , Juvenile Delinquency/legislation & jurisprudence , Male , Residential Facilities/legislation & jurisprudence , WalesABSTRACT
In a coronary care unit patients and electrocardiographic monitors are under almost continuous observation by trained personnel. This paper suggests that in a general medical ward without this facility routine cardiac monitoring with E.C.G. oscilloscopes is unlikely to lower the overall mortality from acute myocardial infarction. A mortality of 25% for acute myocardial infarction was the same for a hospital without a coronary care unit where monitoring was routinely performed and for two neighbouring hospitals which did not routinely use monitoring during the period of analysis.The need to train personnel in the recognition of E.C.G. monitor tracings and the difficulties associated with monitor alarm systems are emphasized.
