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Gastroenterol Clin Biol ; 34(11): 621-4, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20934289

ABSTRACT

BACKGROUND AND AIMS: An association between Budd-Chiari syndrome (BCS) and celiac disease (CD) is uncommon. The aims of our study were to investigate the etiology of BCS and to search for a particular HLA Ag pattern among patients. PATIENTS AND METHODS: BCS diagnosis was based on Doppler ultrasound and CD diagnosis on duodenal biopsy, transglutaminase (TGAb) and gliadin antibodies (GAb). Patients were screened for prothrombotic disorders and seven had a PCR-SSO test for HLA genotypes. Patients were treated with anticoagulants and gluten-free diet. RESULTS: Nine patients were included; mean age 27 years (20-42); sex ratio (F/M) 2; mean follow-up duration 31 months (6-54). All patients had endoscopic and histological features of CD. GAb/TGAb were found in 78 % (n=7). Ag HLA found were HLA DQß1(*)02 (n=6) and DQß1(*)03 (n=3). Prothrombotic conditions identified were latent myeloproliferative disorder (n=1), protein C deficiency (n=1), probable factor V Leiden (n=1) and oral contraceptive use (n=1). No prothrombotic state could be identified in the five other patients. CONCLUSION: The BCS-CD association is relatively frequent in our country. Underlying prothrombotic conditions were absent in more than 50 % of cases, suggesting CD plays a role in the occurrence of thrombosis. HLA alleles found are strongly associated with CD, without any particular pattern for the BCS-CD association.


Subject(s)
Budd-Chiari Syndrome/complications , Budd-Chiari Syndrome/diagnosis , Celiac Disease/complications , Celiac Disease/diagnosis , Adult , Antibodies/blood , Anticoagulants/therapeutic use , Biomarkers/blood , Budd-Chiari Syndrome/blood , Budd-Chiari Syndrome/immunology , Budd-Chiari Syndrome/therapy , Celiac Disease/blood , Celiac Disease/immunology , Celiac Disease/therapy , Diet, Gluten-Free , Female , Follow-Up Studies , Gliadin/blood , HLA-DQ Antigens/blood , Humans , Male , Risk Factors , Transglutaminases/blood
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