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Ann Oncol ; 29(6): 1468-1475, 2018 06 01.
Article in English | MEDLINE | ID: mdl-29617726

ABSTRACT

Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.


Subject(s)
Biomarkers, Tumor/blood , Carcinoma, Non-Small-Cell Lung/epidemiology , Lung Neoplasms/epidemiology , Small Cell Lung Carcinoma/epidemiology , Vitamin D Deficiency/physiopathology , Vitamin D/blood , Adenocarcinoma/blood , Adenocarcinoma/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Carcinoma, Large Cell/blood , Carcinoma, Large Cell/epidemiology , Carcinoma, Non-Small-Cell Lung/blood , Carcinoma, Squamous Cell/blood , Carcinoma, Squamous Cell/epidemiology , Case-Control Studies , Female , Follow-Up Studies , Global Health , Humans , Lung Neoplasms/blood , Male , Middle Aged , Prognosis , Prospective Studies , Risk Factors , Small Cell Lung Carcinoma/blood , Vitamins/blood , Young Adult
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