ABSTRACT
Enteral administration of oxymethyluracil in non-inbred albino rats decreased the inflammatory reaction to histamine, serotonin, bradykinin, carrageenan and trypsin, (being similar to voltaren) and reduced granulomatous inflammation, but influenced the proliferation to a lower extent than did voltaren. In contrast to voltarcen, oxymethyluracil also exhibited gastroprotective antiulcer properties.
Subject(s)
Antioxidants/administration & dosage , Ulcer/drug therapy , Uracil/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Bradykinin/toxicity , Carrageenan/toxicity , Diclofenac/administration & dosage , Histamine/toxicity , Histamine Agents/toxicity , Inflammation/chemically induced , Inflammation/drug therapy , Male , Rats , Serotonin/toxicity , Serotonin Agents/toxicity , Trypsin/toxicity , Ulcer/chemically induced , Uracil/administration & dosage , Vasodilator Agents/toxicityABSTRACT
Well-known and newfound properties of milk thistle (Silybum marianum) preparations are considered (including hepatoprotector, immunostimulant, antiproliferative, antisclerotic, etc.) and the ways of their realization are analyzed. Good prospects of further development of the drugs based on this medicinal plant are emphasized and the possibilities of wider clinical use are discussed.
Subject(s)
Silybum marianum , Animals , Humans , Plant Preparations/pharmacology , Plant Preparations/therapeutic use , Protective Agents/pharmacology , Protective Agents/therapeutic useABSTRACT
Data available in the literature and the results of original investigations of the effect of drugs on the free-radical oxidation process are summarized. It is pointed out that the character of drug influence on the on the free-radical oxidation process must be taken into account in selecting drugs for the treatment of particular diseases.
Subject(s)
Free Radicals/metabolism , Lipid Peroxidation/drug effects , Pharmaceutical Preparations , Animals , Antioxidants/pharmacokinetics , Antioxidants/pharmacology , HumansABSTRACT
The article deals with information in the literature on the peculiarities of the response to drugs and the change of their pharmacokinetics in diabetes mellitus.
Subject(s)
Diabetes Mellitus, Experimental/metabolism , Diabetes Mellitus/metabolism , Pharmaceutical Preparations , Pharmacokinetics , Animals , Biotransformation , Drug Resistance , Drug-Related Side Effects and Adverse Reactions , Female , Humans , Pregnancy , Receptors, Drug/drug effectsABSTRACT
The effect of isradepin, ramipril, ednyt, and beta-adrenoblockers on carbohydrate and lipid metabolism and free-radical oxidation in patients with insulin-independent diabetes mellitus was studied. Isradepin caused an increase in high-density lipoproteins (HDLP) in the blood serum and the content of esterified cholesterol in HDLP, and reduced the arterogenicity coefficient. Rampiril reduced the basal level of glycemia and insulin. Treatment with ednyt lead to increase in the content of HDLP and the content of free cholesterol in them. In the course of treatment isradepin normalized chemoluminescence of the serum and urine, rampiril that of serum, and beta-adrenoblockers the chemoluminescence of the blood. The favorable changes induced by the drugs under study allow them to be recommended for the treatment of arterial hypertension in patients with insulin-independent diabetes mellitus.
Subject(s)
Adrenergic beta-Antagonists/pharmacology , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Antihypertensive Agents/pharmacology , Calcium Channel Blockers/pharmacology , Diabetes Mellitus, Type 2/metabolism , Enalapril/pharmacology , Hypertension/metabolism , Isradipine/pharmacology , Ramipril/pharmacology , Adrenergic beta-Antagonists/administration & dosage , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Antihypertensive Agents/administration & dosage , Calcium Channel Blockers/administration & dosage , Delayed-Action Preparations , Diabetes Mellitus, Type 2/drug therapy , Enalapril/administration & dosage , Female , Free Radicals/metabolism , Glucose Tolerance Test , Humans , Hypertension/drug therapy , Isradipine/administration & dosage , Luminescent Measurements , Male , Ramipril/administration & dosageABSTRACT
The effect of 12.5 and 25 mg/kg doses of erythromycin on the immunity of intact mice and in cyclophosphan- and azathioprine-induced immunodeficiency was studied. Erythromycin has no effect on the number of antibody-forming cells in the spleen of intact and immunocompromised with cyclophosphan animals. It increases their number against the background of azathioprine. Immunosuppression may change the character of the effect of erythromycin on delayed hypersensitivity. Erythromycin stimulates phagocyte activity in intact animals and in immunosuppression.
Subject(s)
Anti-Bacterial Agents/pharmacology , Erythromycin/pharmacology , Immunologic Deficiency Syndromes/chemically induced , Animals , Anti-Bacterial Agents/therapeutic use , Antibody Formation/drug effects , Azathioprine , Cyclophosphamide , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Erythromycin/therapeutic use , Female , Immunity, Cellular/drug effects , Immunologic Deficiency Syndromes/immunology , Immunosuppressive Agents , Male , Mice , Proteus Infections/drug therapy , Proteus Infections/immunology , Proteus Infections/mortality , Proteus mirabilis , Time FactorsABSTRACT
Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.
Subject(s)
Anti-Ulcer Agents/therapeutic use , Pentoxyl/analogs & derivatives , Pyrimidines/therapeutic use , Stomach Ulcer/drug therapy , Uracil/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal , Aspirin , Diclofenac , Disease Models, Animal , Drug Evaluation, Preclinical , Indomethacin , Pentoxyl/therapeutic use , Rats , Stomach Ulcer/chemically induced , Uracil/therapeutic useABSTRACT
Pyrimidine derivatives increased the antibiotic therapy efficacy in albino rats irradiated with RUM-7 apparatus for close-focus roentgenotherapy. 2-Methyl-4-amino-6-oxypyrimidine was twice as efficient as oxymethyluracil and 6 times as efficient as methyluracil in the stimulation of the skin reparative regeneration. When the total irradiation was performed with LUCH-1 apparatus in a dose of 6 Gy the pyrimidine derivatives also increased the antibiotic therapy efficacy. After the prophylactic use of the pyrimidine derivatives for 7 days prior to the total irradiation their therapeutic effect increased, the level of the exudative component lowered, the tissue epithelization increased, the terms of the wound healing decreased and the animal lifespan increased.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Chloramphenicol/therapeutic use , Pyrimidines/pharmacology , Radiation Injuries, Experimental/drug therapy , Radiation-Protective Agents/pharmacology , Skin/drug effects , Wound Healing/drug effects , Administration, Topical , Animals , Anti-Bacterial Agents/administration & dosage , Blood Cell Count , Burns/blood , Burns/complications , Burns/drug therapy , Chloramphenicol/administration & dosage , Drug Therapy, Combination , Pyrimidines/therapeutic use , Radiation Injuries, Experimental/blood , Radiation Injuries, Experimental/complications , Radiation-Protective Agents/therapeutic use , Rats , Skin/radiation effects , Uracil/analogs & derivatives , Uracil/pharmacology , Uracil/therapeutic use , Whole-Body Irradiation , Wound Healing/radiation effectsABSTRACT
The effect of 3 and 6 mg/kg gentamicin on the immunity of intact mice and cyclophosphan- and azathioprine-induced immunodeficiency was studied. Gentamicin deepens the severe suppression of antibody genesis against the background of cyclophosphan and azathioprine, inhibits the reaction of GZT in intact mice. The antibiotic does not prevent stimulation of AOK production by methyluracil and prodigiosan, and does not change the effect of immunostimulators on GZT in immunosuppression. Gentamicin has no effect on the phagocytic activity of neutrophils and macrophages in intact animals. The character of the effect of the antibiotic on phagocytosis depends on the genesis of immunosuppression. The effectiveness of gentamicin in experimental infection is maintained in immunosuppression also.
Subject(s)
Adjuvants, Immunologic/pharmacology , Anti-Bacterial Agents/pharmacology , Gentamicins/pharmacology , Immunologic Deficiency Syndromes/immunology , Animals , Antibody-Producing Cells/drug effects , Antibody-Producing Cells/immunology , Azathioprine , Cyclophosphamide , Dose-Response Relationship, Drug , Drug Interactions , Female , Hypersensitivity, Delayed/immunology , Immunity, Cellular/drug effects , Immunologic Deficiency Syndromes/chemically induced , Immunosuppressive Agents , Male , Mice , Phagocytosis/drug effects , Proteus Infections/immunology , Proteus mirabilisABSTRACT
It was shown on noninbred albino rats with various affections of the skin that pyrimidine derivatives stimulated the skin reparative regeneration and increased the efficacy of antibiotic therapy of Staphylococcus and Proteus infected wounds. The therapeutic effect of 2-methyl-4-amino-6-oxypyrimidine was much higher than that of oxymethyluracil or methyluracil. The pyrimidine derivatives proved to be universal accelerators for reparative regeneration, were compatible with antibiotics and increased their efficacy.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Proteus Infections/drug therapy , Pyrimidines/therapeutic use , Skin/drug effects , Staphylococcal Infections/drug therapy , Wound Infection/drug therapy , Animals , Anti-Bacterial Agents/pharmacology , Drug Synergism , Rats , Uracil/analogs & derivatives , Uracil/therapeutic use , Wound Healing/drug effectsABSTRACT
The effect of rifampicin on antibody genesis depends on the dose, duration, and time of its administration in relation to the antigen, as well as on the character of immunosuppression. The antibiotic has no effect on delayed hypersensitivity and stimulates the activity of phagocytes, predominantly that of neutrophils. The effectiveness of rifampicin in experimental infection is maintained in treatment with cyclophosphane and azathioprine. When administered in combination with rifampicin and cytostatics methyluracil possesses a broader spectrum of immunostimulating activity than that of prodigiosin and levamisole.
Subject(s)
Adjuvants, Immunologic/pharmacology , Antibiotics, Antitubercular/pharmacology , Rifampin/pharmacology , Animals , Antibody Formation/drug effects , Azathioprine/pharmacology , Cyclophosphamide/pharmacology , Dose-Response Relationship, Drug , Drug Interactions , Female , Immunity, Cellular/drug effects , Immunity, Innate/drug effects , Immunosuppressive Agents/pharmacology , Male , Mice , Phagocytes/drug effects , Phagocytes/immunology , Proteus Infections/immunology , Proteus Infections/mortality , Proteus mirabilis , Time FactorsABSTRACT
The effect of 50 and 100 mg/kg doses of ampicillin, immunocompromised by cyclophan and azathioprine, on immunity of intact mice was studied. Ampicillin did not change the number of antibody-forming cells (AFC) and delayed hypersensitivity (DHS) in immunosuppression. It inhibited spontaneous oxidant metabolism of neutrophils and macrophages against the background of azathioprine. The therapeutic effect of ampicillin was maintained under such conditions. In intact animals the antibiotic did not change the number of AFC, increased DHS expression, and reduced the spontaneous index of macrophage activation in the nitroblue tetrazolium test.
Subject(s)
Ampicillin/pharmacology , Antibody Formation/drug effects , Azathioprine/pharmacology , Cyclophosphamide/pharmacology , Immunity, Cellular/drug effects , Immunosuppressive Agents/pharmacology , Penicillins/pharmacology , Animals , Antibody-Producing Cells/drug effects , Antibody-Producing Cells/immunology , Dose-Response Relationship, Drug , Female , Male , Mice , Phagocytosis/drug effects , Phagocytosis/immunology , Proteus Infections/immunology , Proteus mirabilisABSTRACT
The effect of the immunomodulator 2-methyl-4-amino-6-oxypyrimidine (MAOP)on delayed hypersensitivity was studied in experiments on mongrel mice and in C57Bl and CBA mice. The effect of MAOP and that of oxymethyluracil on delayed hypersensitivity to sheep erythrocytes and dinitrofluorobenzene were compared. Immunosuppression of mice was induced by hydrocortisone in a dose of 50 mg/kg.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Hypersensitivity, Delayed/prevention & control , Pyrimidines/therapeutic use , Animals , Dinitrofluorobenzene , Drug Evaluation, Preclinical , Hypersensitivity, Delayed/drug therapy , Hypersensitivity, Delayed/etiology , Hypersensitivity, Delayed/immunology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Pentoxyl/analogs & derivatives , Pentoxyl/therapeutic use , T-Lymphocytes, Regulatory/drug effects , T-Lymphocytes, Regulatory/immunologyABSTRACT
White mongrel mice (150 specimens) were used to study the effect of 2-methyl-4-amine-6-oxypyrimidine (MAOP) on the absorption capacity of reticulo-endothelial system (RES) compared to the oxymethyluracil. It was demonstrated that the MAOP stimulates much greater the absorption capacity of RES in different functional states than the oxymethyluracil.
Subject(s)
Mononuclear Phagocyte System/drug effects , Phagocytosis/drug effects , Pyrimidines/pharmacology , Animals , Drug Interactions , Fatigue/physiopathology , Female , Male , Mice , Mononuclear Phagocyte System/physiology , Pentoxyl/analogs & derivatives , Pentoxyl/pharmacologyABSTRACT
The effect of pyrimidine, levamizol, and prodigiozan on the retarded hypersensitivity (RH) was studied on a model of adoptive transfer of the splenocytes from donors of different ages to young syngeneic recipients. Splenocytes from CBA and BALB/c suckers, receiving pyrimidine, activate the RH suppression. Levamizol and prodigiozan exert the same effect on BALB/c mice and inhibit the RH suppression in CBA mice. In mature CBA mice these preparations potentiate HST. The splenocytes from young and aged BALB/c donors receiving the preparations oppositely induce the RH recipients.
Subject(s)
Aging/drug effects , Epitopes/drug effects , Hypersensitivity, Delayed/immunology , Levamisole/pharmacology , Prodigiozan/pharmacology , Pyrimidines/pharmacology , Aging/immunology , Animals , Animals, Suckling , Epitopes/immunology , Female , Immunization, Passive/methods , Mice , Mice, Inbred BALB C , Mice, Inbred CBA , Spleen/immunology , Spleen/transplantation , T-Lymphocytes, Regulatory/drug effects , T-Lymphocytes, Regulatory/immunology , Transplantation, IsogeneicSubject(s)
Analgesics, Opioid/pharmacology , Morphinans/pharmacology , Solvents , Animals , Lethal Dose 50 , MiceABSTRACT
The experiments on mice showed that some derivatives of pyrimidine i.e. 2-methyl-6-amino-6-oxypyrimidine and oxymisin increased the levomycetin efficacy in the treatment of experimental infections. The effect of 2-methyl-6-amino-6-oxypyrimidine proved to be higher in comparison to that of oxymethyluracil.
Subject(s)
Bacterial Infections/drug therapy , Chloramphenicol/pharmacology , Paromomycin/pharmacology , Pyrimidines/pharmacology , Drug SynergismABSTRACT
The effects of maninile and obsidan and their combined action on metabolic processes were studied in a series of in vitro experiments. The metabolic processes serve as a prerequisite to energy supply and couple the anabolic and catabolic pathways of hepatic metabolism. The rate of aerobic and anaerobic oxidation of glucose was shown to decrease when maninile was in close contact with liver tissue. It is indicative of the indirect hypoglycemic action of maninile. There is evidence for the combined use of maninile and obsidan since it allows the balance of regulatory metabolites to be maintained. Also, metabolic changes became less if they were used in combination rather alone.