Oral administration of resveratrol reduces oxidative stress generated in the hippocampus of Wistar rats in response to consumption of ethanol.

Introduction: Chronic ethanol intake has been found to favor hippocampal deterioration and alter neuronal morphological maturation; resveratrol has been suggested as an antioxidant that may counteract these effects. The objective of this study was to analyze the effect of resveratrol on oxidative stress markers, endogenous antioxidant system in the hippocampus, and the behavior of male Wistar rats administered different concentrations of ethanol. Methods: The animals, at 3 months old, were randomly distributed into 11 study groups (n = 6/group), orally administered (5 days on, 2 days off) with water (control), ethanol (10, 20, 30, 40 or 50%), or ethanol (10, 20, 30, 40 or 50%) plus resveratrol (10 mg/Kg/day) for 2 months. Subsequently, the production of nitrites, malondialdehyde, and 4-hydroxy-alkenal (HNE) and the enzymatic activity of catalase and superoxide dismutase (SOD) were quantified. Results: The levels of nitric oxide and lipid peroxidation products were significantly increased in each ethanol concentration and were statistically different compared to the control group; however, resveratrol significantly reduced oxidative stress caused by high ethanol concentration. The SOD and CAT did not present significant changes with respect to the controls in any of the study groups. In the different concentrations of ethanol used, GR increases significantly in the groups administered with resveratrol but not GPx. Resveratrol was shown to maintain the results similar to the control at most ethanol concentrations. Discussion: Our results suggest that resveratrol prevents oxidative stress induced by ethanol in the hippocampus by decreasing cellular lipid peroxidation, but does not prevent the activation of catalase or SOD enzymes; however, allows glutathione to be kept active and in adequate concentrations in its reduced form and avoids alterations in the locomotor system.

Association of Differences in Dietary Behaviours and Lifestyle with Self-Reported Weight Gain during the COVID-19 Lockdown in a University Community from Chile: A Cross-Sectional Study.

Domiciliary confinement of people is one of the main strategies to limit the impact of COVID-19. Lockdowns have led to changes in lifestyle, emotional health, and eating habits. We aimed to evaluate the association of differences in dietary behaviours and lifestyle with self-reported weight gain during the COVID-19 lockdown in Chile. In this cross-sectional analytical study, five previously validated surveys were condensed into a single 86-item online questionnaire. The survey was sent to 1000 potential participants of the university community; it was kept online for 28 days to be answered. Of the 639 respondents, the mean self-reported weight gain during confinement was 1.99 kg (standard deviation [SE]: 0.17) and 0.7 (SE: 0.06) units of body mass index (BMI) (both p < 0.001) and the median difference in body weight during lockdown was 3.3% (interquartile range [IQR]: 0.0-6.7). The differences of intake of most food groups before and during lockdown were associated with greater self-reported weight, BMI and percentage weight gain. Differences in lifestyle (odds ratio [OR] = 14.21, 95% confidence interval [95%CI]: 2.35-85.82) worsening eating habits (OR = 3.43, 95%CI: 2.31-5.09), and more consumption of sweet or filled cookies and cakes during lockdown (OR = 2.11, 95%CI: 1.42-3.13) were associated with self-reported weight gain. In conclusion, different dietary behaviours (mainly consumption of industrialized foods) during lockdown, as well as quality of life deterioration were the main factors associated with self-reported weight gain during lockdown.

Food Insecurity Is Associated with the Quality of Diet of Non-Institutionalized Older Adults from a Southern Chilean Commune: A Cross-Sectional Study.

As the population ages, greater attention to age-related health problems related to diet and lifestyles is needed. Here, we sought to evaluate the associations between demographic and clinical characteristics and food insecurity with the quality of diet of non-institutionalized elderly from a southern Chilean commune. We performed an analytical cross-sectional study in a sample of 376 older adults. Nutritional status was evaluated through anthropometric measurements. Quality of diet was determined by the healthy eating index (HEI), obtained through the frequency of consumption questionnaire. Socioeconomic, demographic, and lifestyle variables were also collected. Ordinal logistic and Poisson regression models were applied to study associations with quality of diet. The sample consisted of more women (81.6%) than men (18.4%). Most older adults were found to live in a situation of vulnerability or poverty (82.4%), with most having food security (65.7%). According to the HEI, only 14.1% had a good quality of diet, 83.8% had diet in need of improvement, and 2.1% had an unhealthy diet. There was an association of food insecurity and cardiovascular risk (according to waist circumference) with lower quality of diet categories. However, an association with the unhealthy quality of diet category was not confirmed with Poisson regression analysis, which was possibly due to the low number of subjects in that category (n = 8, 2.1%). Other modifiable factors like physical activity, hours of sleep, and polypharmacy were not associated with lower quality of diet categories. Socioeconomic status, which is a structural health determinant, was not associated with decreased quality of diet. Since this was a cross-sectional study performed on a small sample from a Chilean commune, directionality of associations cannot be discerned, and future longitudinal studies could aim to better characterize these associations in larger samples of elderly patients.

IMPACT OF COMORBIDITIES IN MEXICAN SARS-COV-2-POSITIVE PATIENTS: A RETROSPECTIVE ANALYSIS IN A NATIONAL COHORT.

BACKGROUND: The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world. OBJECTIVE: The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population. MATERIALS AND METHODS: We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. We investigated the risk of death and the development of adverse events (hospitalization, pneumonia, orotracheal intubation, and intensive care unit [ICU] admission), comparing the number of comorbidities of each patient. RESULTS: The patient mean age was 46.6 ± 15.6 years, 42.3% (n = 5853) of the cases were women, 38.8% of patients were hospitalized, 4.4% were intubated, 29.6% developed pneumonia, and 4.4% had critical illness. The CFR was 9.4%. The risk of hospitalization (odds ratio [OR] = 3.1, 95% confidence interval [CI]: 2.7-3.7), pneumonia (OR = 3.02, 95% CI: 2.6-3.5), ICU admission (OR = 2, 95% CI: 1.5-2.7), and CFR (hazard ratio = 3.5, 95% CI: 2.9-4.2) was higher in patients with three or more comorbidities than in patients with 1, 2, or with no comorbidities. CONCLUSIONS: The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients.

Impact of comorbidities in mexican SARS-COV-2-positive patients: a retrospective analysis in a national cohort

ABSTRACT Background: The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world. Objective: The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population. Materials and methods: We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. We investigated the risk of death and the development of adverse events (hospitalization, pneumonia, orotracheal intubation, and intensive care unit [ICU] admission), comparing the number of comorbidities of each patient. Results: The patient mean age was 46.6 ± 15.6 years, 42.3% (n = 5853) of the cases were women, 38.8% of patients were hospitalized, 4.4% were intubated, 29.6% developed pneumonia, and 4.4% had critical illness. The CFR was 9.4%. The risk of hospitalization (odds ratio [OR] = 3.1, 95% confidence interval [CI]: 2.7-3.7), pneumonia (OR = 3.02, 95% CI: 2.6-3.5), ICU admission (OR = 2, 95% CI: 1.5-2.7), and CFR (hazard ratio = 3.5, 95% CI: 2.9-4.2) was higher in patients with three or more comorbidities than in patients with 1, 2, or with no comorbidities. Conclusions: The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients.

Use of coconut water (Cocus nucifera L) for the development of a symbiotic functional drink.

Many studies suggest that probiotic, prebiotic and symbiotic foods may be beneficial in the prevention and management of nutrition and health, the objective of this work was to develop a symbiotic drink based on coconut water. Fermentation was performed using lyophilized Lactobacillus rhamnosus SP1 and inulin as a source of soluble fiber. Different formulations were developed, determining the concentrations of fiber and probiotics. The growth of the probiotic in MRS broth was evaluated, using the plate counting technique in different periods of time. The fermentation time of the drink was 8 h and the shelf life in refrigeration was 14 days evaluated by pH and hedonic scale. The pH of the final drink was 3.48 and the probiotic content was 82 × 10 8 CFU/ml. It is concluded that coconut water can be processed by adding probiotic and prebiotic characteristics with sensory acceptance and adequate preservation characteristics.

Estado nutricional, ingesta de alimentos, horas de sueño y riesgo cardiovascular en trabajadoras de turno nocturno en una empresa frutícola de la ciudad de Chillán, Chile / Nutritional status, food intake, sleeping hours and cardiovascular risk in night shift women workers in a fruit company in the city of Chillan, Chile

FUNDAMENTOS: El trabajo nocturno genera estilos de vida irregulares y se asocia con un aumento en la morbilidad de los trabajadores, especialmente las mujeres. Las posibles causas de este aumento serían un consumo excesivo de energía y el riesgo cardiovascular, por lo que el objetivo es determinar la relación entre el estado nutricional, adecuación de la dieta, riesgo cardiovascular y horas de sueño en mujeres que trabajan en el turno nocturno de una empresa frutícola. MÉTODOS: Estudio transversal con una muestra de 61 mujeres trabajadoras de turno nocturno de una empresa frutícola de Chile. La composición y la distribución corporal se determinaron mediante bioimpedancia tetrapolar y el cálculo del índice cintura/estatura e índice cintura/cadera respectivamente. La contribución de la dieta se cuantificó mediante registro de alimentos,el nivel de actividad física mediante el cuestionario IPAQ y el cuestionario del sueño del Instituto Nacional de Tecnología de Alimentos (INTA) de la Universidad de Chile. RESULTADOS: El 85% de las mujeres presentaron sobrepeso u obesidad (n=52). La frecuencia de sedentarismo fue mayor en las mujeres con sobrepeso (n= 26;100%) y obesidad (n=25;96%), por otro lado, las horas de sueño fueron menores en estos estados de nutrición que en las mujeres con normopeso (p < 0,02). El sedentarismo (OR=22,5; IC95%:1,5-320,3; p = 0,02) y las pocas horas de sueño (OR=7,2; IC95%: 1,1-47,2; p = 0,04) fueron encontrados como factores de riesgo para sobrepeso u obesidad en dos modelos multivariados de regresión logística. CONCLUSIONES: La mayoría de las mujeres presentó sobrepeso u obesidad así como mayor riesgo cardiovascular dependiente del sedentarismo y malos hábitos de sueño

BACKGROUND: Night work generates irregular lifestyles and is associated with an increase in the morbidity of workers, especially women. The possible causes of this increase would be excessive energy consumption and cardiovascular risk, so the objective of the present study is to determine the relationship between nutritional status, diet adequacy, cardiovascular risk and sleep hours in women who work in the night shift of a fruit company. METHODS: Cross-sectional study with a sample of 61 women working night shifts from a fruit company in Chile. Body composition and distribution were determined by tetrapolar bioimpedance and the calculation of the waist/height index and waist/hip index respectively. The contribution of the diet was quantified by means of food registration, the level of physical activity through the IPAQ questionnaire and the sleep questionnaire of the National Institute of Food Technology (INTA) of the University of Chile was applied. RESULTS: 85% of the women were overweight or obese (n = 52). The frequency of sedentary lifestyle was higher in women who were overweight (n = 26; 100%) and obese (n = 25; 96%), on the other hand, the hours of sleep were lower in these nutritional states than in women with normal weight (p <0.02). Sedentary lifestyle (OR = 22.5; 95% CI: 1.5-320.3; p = 0.02) and the few hours of sleep (OR = 7.2; 95% CI: 1.1-47.2; p = 0.04) were found as risk factors for overweight or obesity in two multivariate logistic regression models. CONCLUSIONS: The majority of women were overweight or obese, as well as increased cardiovascular risk depending on sedentary lifestyle and poor sleep habits

Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies.

Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living species; according to some botanists, it would contain about 16-20% of the species that exist today. This region has native fruit trees in which functional properties are reported as antioxidant and antiproliferative characteristics. Amazon plants offer a great therapeutic potential attributed to the content of bioactive phytochemicals. The aim of this mini review is to examine the state of the art of the main bioactive components of the most studied Amazonian plants. Among the main functional compounds reported were phenolic compounds, unsaturated fatty acids, carotenoids, phytosterols, and tocopherols, with flavonoids and carotenoids being the groups of greatest interest. The main beneficial effect reported has been the antioxidant effect, evaluated in most of the fruits investigated; other reported functional properties were antimicrobial, antimutagenic, antigenotoxic, analgesic, immunomodulatory, anticancer, bronchodilator, antiproliferative, and anti-inflammatory, including hypercholesterolemic effects, leishmanicidal activity, induction of apoptosis, protective action against diabetes, gastroprotective activity, and antidepressant effects.

Hábitos alimentarios en una población de jóvenes universitario (18-25 años) de la ciudad de Puebla / Eating habits in a population of university student (18-25 years) of the city of Puebla

Fundamentos: Algunos estudios han puesto de relieve la existencia en jóvenes de hábitos alimentarios incorrectos y desconocimiento respecto a las características de una dieta equilibrada, y la relación que tiene la presencia de sobrepeso, obesidad, escasa actividad física y mala calidad de la dieta como factores de riesgo para desarrollar enfermedades crónico-degenerativas a corto o mediano plazo. Métodos: Se realizó un estudio descriptivo exploratorio de carácter transversal con una muestra de 254 hombres y 246 mujeres. estudiantes de diversas facultades de la Benemérita Universidad Autónoma de Puebla de la ciudad de Puebla, México. Resultados: La población refiere si desayunar, sin embargo, no lo hacen muy frecuentemente debido a la falta de tiempo, y la mayoría ingiere alimentos durante el día dentro de la universidad, principalmente comida rápida que provee de energía en exceso y que no aporta suficientes nutrientes esenciales. En cuanto a cultura nutricional. las mujeres poseen mayores conocimientos que los hombres en general, pero esto no incide sobre una mejora en sus hábitos alimentarios. Conclusiones: Los hábitos y conocimientos alimentarios de la población estudiada, no son satisfactorios, se preocupan por no aumentar de peso. y los horarios escolares tan exigentes son su principal impedimento para lograr llevar una dieta adecuada. Se considera una necesidad fundamental la orientación nutricional incluso a nivel universitario (AU)

Background: Some studies have highlighted the existence in young people of incorrect eating habits and lack of knowledge regarding the characteristics of a balanced diet, and the relationship of overweight, obesity, low physical activity and poor diet quality as risk factors of developing chronic- degenerative diseases in the short or medium term. Methods: A cross-sectional exploratory descriptive study was carried out with a sample of 254 men and 246 women, students from different faculties of the Autonomous University of Puebla. in the city of Puebla. Mexico. Results: The population reports that they do have breakfast, however, they don t do it very frequently due to lack of time, and most eat food during the day inside the university, is mainly fast food that provides excess energy and does not provide enough essential nutrients. As for nutritional culture. women have greater knowledge than men in general, but this does not affect an improvement in their eating habits. Conclusions: The dietary habits and knowledge of the population studied are not satisfactory, they worry about not gaining weight. and the school hours so demanding are their main impediment to achieving an adequate diet. It is considered a fundamental need for delivery of nutritional guidance even at the university level (AU)