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Acta Neurochir Suppl ; 76: 35-7, 2000.
Article in English | MEDLINE | ID: mdl-11450042

ABSTRACT

This work investigates the accuracy of an in vivo estimation of absolute N-acetyl aspartate (NAA) concentrations by magnetic resonance spectroscopy (MRS) using cerebral water as an internal reference standard. Single-voxel, proton spectroscopy was carried out in two groups of rats (normal and diffuse head injury), using a PRESS sequence with TR = 3 s, TE = 135 ms. Fully relaxed water spectra and water-suppressed proton spectra were obtained from a 7 x 5 x 5 mm3 volume of tissue. MRI-based brain water content measurements were also performed. Following MRS, HPLC determinations of NAA were carried out. In the normal rats the MRS yielded 10.98 +/- 0.83 mmol/kg w.w. vs 10.76 +/- 0.76 for HPLC with a mean absolute difference of 0.8. In the injured rats the corresponding results were 9.41 +/- 1.78 (MRS) and 8.16 +/- 0.77 (HPLC) with a mean absolute difference of 1.66. The in vivo absolute method accurately documented the temporal NAA changes compared to the NAA/Cr approach.


Subject(s)
Aspartic Acid/metabolism , Brain Concussion/physiopathology , Brain Edema/physiopathology , Chromatography, High Pressure Liquid , Energy Metabolism/physiology , Magnetic Resonance Spectroscopy , Animals , Aspartic Acid/analogs & derivatives , Brain Concussion/diagnosis , Brain Edema/diagnosis , Creatine/metabolism , Extracellular Space/physiology , Predictive Value of Tests , Rats
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