1.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 35(2): 261-264, 2018 Apr 10.
Article
in Chinese
| MEDLINE
| ID: mdl-29653006
ABSTRACT
OBJECTIVE: To study a case with weak D59 phenotype identified among ethnic Han Chinese population. METHODS: Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members. RESULTS: A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype. RHD zygosity testing confirmed that the proband had a RHD+ /RHD- genotype. CONCLUSION: A weak D59 phenotype was firstly identified in a Chinese individual.