Catechol-Amyloid Interactions.

This review introduces multifaceted mutual interactions between molecules containing a catechol moiety and aggregation-prone proteins. The complex relationships between these two molecular species have previously been elucidated primarily in a unidirectional manner, as demonstrated in cases involving the development of catechol-based inhibitors for amyloid aggregation and the elucidation of the role of functional amyloid fibers in melanin biosynthesis. This review aims to consolidate scattered clues pertaining to catechol-based amyloid inhibitors, functional amyloid scaffold of melanin biosynthesis, and chemically designed peptide fibers for providing chemical insights into the role of the local three-dimensional orientation of functional groups in manifesting such interactions. These orientations may play crucial, yet undiscovered, roles in various supramolecular structures.

Supramolecular Regulation of Polydopamine Formation by Amyloid Fibers.

Polydopamine (PD) and melanin species are chemically complex systems, the formation and properties of which are incompletely understood. Inspired by the role of functional amyloids in melanin biosynthesis, this paper examines the influences of the supramolecular structure of amyloids on oxidative polymerization of dopamine. Kinetic analyses on the formation of PD species in the presence of hen egg white lysozyme (HEWL) fibers or soluble HEWL revealed that both forms gave rise to the total quantity of PD species, but the rate of their formation could be accelerated only by the amyloid form. PD species formed with HEWL fibers showed a morphology of bundled fibers, whereas those with soluble HEWL had a mesh-like structure. Amyloid fibers of recombinant Pmel17 had properties similar to those of HEWL fibers in modulating PD formation. The results presented here suggest how nature designs functionality with an amyloid structure and can help understand and engineer chemistries of other functional amyloids.

Antibacterial nanoparticles: enhanced antibacterial efficiency of coral-like crystalline rhodium nanoplates.

This paper deals with the newly found antibacterial efficiency of coral-like crystalline Rh nanoplates. Rh nanoplates with rough surface morphology synthesized by inverse-directional galvanic replacement exhibited highly enhanced antibacterial efficiency compared to Rh3+ ion and Rh nanospheres. The observed antibacterial efficiency was comparable to Ag nanoplates, a well-known anticancer nano-agent. Results clearly demonstrate that the composition and morphology of a nanostructure play significant roles in antibacterial effects.