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2.
Food Microbiol ; 79: 1-10, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30621864

ABSTRACT

Twenty Gram-negative bacterial (GNB) strains were selected based on the biodiversity previously observed in French traditional cheeses and their safety was assessed considering various safety criteria. For the majority of tested GNB strains, only gastric stress at pH 2 (vs pH 4) resulted in low survival and no regrowth after an additional simulated gastro-intestinal stress. Presence of milk was shown to be rarely protective. The majority of strains was resistant to human serum and had a low level of adherence to Caco-2 cells. When tested for virulence in Galleria mellonella larvae, GNB strains had LD 50 values similar to that of safe controls. However, four strains, Hafnia paralvei 920, Proteus sp. (close to P. hauseri) UCMA 3780, Providencia heimbachae GR4, and Morganella morganii 3A2A were highly toxic to the larvae, which suggests the presence of potential virulent factors in these strains. Noteworthy, to our knowledge, no foodborne intoxication or outbreak has been reported so far for any of the GNB belonging to the genera/species associated with the tested strains. The role of multiple dynamic interactions between cheese microbiota and GIT barriers could be key factors explaining safe consumption of the corresponding cheeses.


Subject(s)
Cheese/microbiology , Food Microbiology , Food Safety , Gram-Negative Bacteria/pathogenicity , Microbiota , Animals , Bacterial Adhesion , Biodiversity , Blood Bactericidal Activity , Caco-2 Cells , Gastric Acid , Gram-Negative Bacteria/growth & development , Gram-Negative Bacteria/physiology , Humans , Larva/microbiology , Microbial Viability , Milk , Moths/microbiology , Virulence
3.
Sarcoidosis Vasc Diffuse Lung Dis ; 30(1): 65-9, 2013 Mar.
Article in English | MEDLINE | ID: mdl-24003537

ABSTRACT

Nocardiosis is a rare, mixed suppurative and granulomatous, bacterial infection that can affect various organs, but most commonly lungs. Clinical manifestation is usually uncharacteristic; can mimic fungal, parasitic and mycobacterial infections or malignancy. Presentation can be also similar to that of the other granulomatous diseases, among them sarcoidosis. We present an unusual case of disseminated nocardiosis in a patient diagnosed before with sarcoidosis and treated with glucocorticoids. Clinical symptoms initially mimicked exacerbation of pulmonary sarcoidosis. The course of disease was severe.


Subject(s)
Nocardia Infections/diagnosis , Nocardia Infections/epidemiology , Sarcoidosis, Pulmonary/epidemiology , Sarcoidosis, Pulmonary/pathology , Abscess/diagnostic imaging , Abscess/epidemiology , Adult , Anti-Infective Agents/therapeutic use , Diagnosis, Differential , Disease Progression , Glucocorticoids/administration & dosage , Humans , Male , Mediastinal Diseases/diagnostic imaging , Mediastinal Diseases/epidemiology , Methylprednisolone/administration & dosage , Nocardia Infections/pathology , Opportunistic Infections , Tomography, X-Ray Computed , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
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