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1.
Rev Pneumol Clin ; 68(6): 361-3, 2012 Dec.
Article in French | MEDLINE | ID: mdl-23026419

ABSTRACT

Tuberculous involvement of the oesophagus is a rare disease in our country. We report the case of a 76-year-old patient with tuberculous involvement of the oesophagus, who developped an oesophago-lymph nodes fistula. These fistulas are used to be treated by antituberculous chemotherapy. The surgical treatment is rarely needed.


Subject(s)
Esophageal Diseases/microbiology , Tuberculosis, Gastrointestinal/diagnosis , Aged , Antitubercular Agents/therapeutic use , Drug Therapy, Combination , Esophageal Diseases/drug therapy , Esophageal Fistula/etiology , Humans , Male , Tuberculosis, Gastrointestinal/drug therapy
3.
Bioorg Med Chem Lett ; 9(1): 49-54, 1999 Jan 04.
Article in English | MEDLINE | ID: mdl-9990455

ABSTRACT

Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.


Subject(s)
Betaine/analogs & derivatives , Betaine/pharmacology , Chemistry, Organic/methods , Osmotic Pressure/drug effects , Sinorhizobium meliloti/drug effects , Betaine/chemical synthesis , Cell Division , Escherichia coli/drug effects , Escherichia coli/physiology , Sinorhizobium meliloti/physiology , Succimer/pharmacokinetics , Succimer/pharmacology
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