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First case of disseminated infection with Nocardia cerradoensis in a human.

Piau, Caroline; Kerjouan, Mallorie; Le Mouel, Marc; Patrat-Delon, Solene; Henaux, Pierre-Louis; Brun, Vanessa; Morin, Marie-Pascale; Gautier, Philippe; Rodriguez-Nava, Veronica; Kayal, Samer.

J Clin Microbiol ; 53(3): 1034-7, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25568436

ABSTRACT

Here we report in a human, a renal transplant patient, the first disseminated infection with Nocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA, gyrB, and hsp65 gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.

Subject(s)

Nocardia Infections/diagnosis , Nocardia/classification , Nocardia/isolation & purification , Sepsis/diagnosis , Aminoglycosides/therapeutic use , Anti-Bacterial Agents/therapeutic use , Brain/microbiology , Brain/pathology , Carbapenems/therapeutic use , Cluster Analysis , DNA Gyrase , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , DNA, Ribosomal/chemistry , DNA, Ribosomal/genetics , Female , Heat-Shock Proteins , Humans , Kidney Transplantation , Microbial Sensitivity Tests , Microscopy , Middle Aged , Molecular Sequence Data , Nocardia/chemistry , Nocardia/genetics , Nocardia Infections/microbiology , Phylogeny , RNA, Ribosomal, 16S/genetics , Radiography, Abdominal , Radiography, Thoracic , Sepsis/microbiology , Sequence Analysis, DNA , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Transplant Recipients , Treatment Outcome , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use

ABSTRACT

Subject(s)

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