Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Genetics ; 168(4): 2141-55, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15611182

ABSTRACT

In one of the longest-running experiments in biology, researchers at the University of Illinois have selected for altered composition of the maize kernel since 1896. Here we use an association study to infer the genetic basis of dramatic changes that occurred in response to selection for changes in oil concentration. The study population was produced by a cross between the high- and low-selection lines at generation 70, followed by 10 generations of random mating and the derivation of 500 lines by selfing. These lines were genotyped for 488 genetic markers and the oil concentration was evaluated in replicated field trials. Three methods of analysis were tested in simulations for ability to detect quantitative trait loci (QTL). The most effective method was model selection in multiple regression. This method detected approximately 50 QTL accounting for approximately 50% of the genetic variance, suggesting that >50 QTL are involved. The QTL effect estimates are small and largely additive. About 20% of the QTL have negative effects (i.e., not predicted by the parental difference), which is consistent with hitchhiking and small population size during selection. The large number of QTL detected accounts for the smooth and sustained response to selection throughout the twentieth century.


Subject(s)
Corn Oil/genetics , Seeds/metabolism , Selection, Genetic , Zea mays/genetics , Computer Simulation , Corn Oil/metabolism , Epistasis, Genetic , Genes, Dominant , Genetic Markers , Genetic Variation , Linkage Disequilibrium , Phenotype , Quantitative Trait Loci , Regression Analysis , Zea mays/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...