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Bioorg Med Chem Lett
; 15(19): 4359-62, 2005 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-16039856
ABSTRACT
Adamantyl triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure-activity relationships of these inhibitors are presented.