Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Inorg Biochem ; 246: 112294, 2023 09.
Article in English | MEDLINE | ID: mdl-37356379

ABSTRACT

Redox-active azothioformamides (ATFs) contain an NNCS 1,3-heterodiene motif typically found in other molecular subclasses that exhibit a wide range of cytotoxic and anti-neoplastic effects, either alone or as chelation complexes with various metals. For this study, a small library of ATF compounds was synthesized and tested across a range of microbes, fungi, and cancer cell lines for biological activity, both alone and as metal chelates of copper(I) and silver(I) salts. Alone, the ATF compounds exhibited little antimicrobial activity, but all inhibited the cell growth of A549 lung carcinoma cells (IC50 values of 1-6 µM). As copper(I) and silver(I) coordination complexes, several of the ATFs showed antimicrobial activity against gram positive Staphylococcus aureus and Bacillus subtilis cells (IC50 âˆ¼ 5-20 µM) and the fungi Candida albicans (IC50 âˆ¼ 8-12 µM); as well as cytotoxicity against both lung carcinoma A549 cells and lymphoblastic leukemia K562 cells.


Subject(s)
Anti-Infective Agents , Antineoplastic Agents , Carcinoma , Coordination Complexes , Humans , Copper/pharmacology , Anti-Infective Agents/pharmacology , Anti-Infective Agents/metabolism , Silver/pharmacology , Cell Line , Coordination Complexes/pharmacology , Chelating Agents/pharmacology , Fungi , Microbial Sensitivity Tests , Antineoplastic Agents/pharmacology , Anti-Bacterial Agents/pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL
...