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1.
A route to small-molecule Lp(a) inhibitors for heart disease.
Leake, Isobel.
Nat Rev Drug Discov ; 23(7): 498, 2024 07.
Article in English | MEDLINE | ID: mdl-38858570

Subject(s)
Heart Diseases , Humans , Heart Diseases/drug therapy , Lipoprotein(a)/blood , Lipoprotein(a)/antagonists & inhibitors , Animals , Small Molecule Libraries/pharmacology
2.
Brain functional networks and psychiatric disorders.
Leake, Isobel.
Nat Rev Neurosci ; 25(7): 450, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38760459

Subject(s)
Brain , Mental Disorders , Nerve Net , Humans , Mental Disorders/physiopathology , Brain/physiology , Nerve Net/physiology , Animals , Neural Pathways/physiology
3.
Attentional capture.
Leake, Isobel.
Nat Rev Neurosci ; 25(6): 373, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38622274

Subject(s)
Attention , Humans , Attention/physiology , Animals , Brain/physiology
4.
Hyperprogression during immunotherapy.
Leake, Isobel.
Nat Cancer ; 4(12): 1640, 2023 Dec.
Article in English | MEDLINE | ID: mdl-38102345

Subject(s)
Immunotherapy , Humans , Disease Progression , Immunotherapy/adverse effects
5.
Glioblastomas remodel neural circuits.
Leake, Isobel.
Nat Rev Cancer ; 23(7): 428, 2023 07.
Article in English | MEDLINE | ID: mdl-37280426

Subject(s)
Brain Neoplasms , Glioblastoma , Humans , Glioblastoma/genetics , Brain Neoplasms/genetics
6.
Oligomeric tau might spread trans-synaptically in Alzheimer disease.
Leake, Isobel.
Nat Rev Neurosci ; 24(7): 393, 2023 07.
Article in English | MEDLINE | ID: mdl-37237104

Subject(s)
Alzheimer Disease , Humans , tau Proteins , Neurons
7.
Genotoxins from gut bacteria.
Leake, Isobel.
Nat Biotechnol ; 40(12): 1765, 2022 12.
Article in English | MEDLINE | ID: mdl-36477510

Subject(s)
Bacteria , Mutagens , DNA Damage
8.
Insights into metastases.
Leake, Isobel.
Nat Cancer ; 3(12): 1436, 2022 12.
Article in English | MEDLINE | ID: mdl-36539482

Subject(s)
Brain Neoplasms , Lung Neoplasms , Humans , Lung Neoplasms/pathology , Brain Neoplasms/secondary , Problem Solving
9.
Exploring cancer mycobiomes.
Leake, Isobel.
Nat Cancer ; 3(12): 1442, 2022 12.
Article in English | MEDLINE | ID: mdl-36539485

Subject(s)
Mycobiome , Neoplasms , Fungi
10.
Pediatric cancer incidence in China.
Leake, Isobel.
Nat Cancer ; 3(12): 1444, 2022 12.
Article in English | MEDLINE | ID: mdl-36539492

Subject(s)
Neoplasms , Child , Humans , Incidence , China/epidemiology , Neoplasms/epidemiology
11.
Microglial calcium activity in ischaemic brain injury.
Leake, Isobel.
Nat Rev Neurol ; 17(1): 2, 2021 01.
Article in English | MEDLINE | ID: mdl-33268849
12.
Biomarkers for predicting stability of aMCI.
Leake, Isobel.
Nat Rev Neurol ; 17(1): 2, 2021 01.
Article in English | MEDLINE | ID: mdl-33268850
13.
Exome sequencing for diagnosing uncommon paediatric neuromuscular disease.
Leake, Isobel.
Nat Rev Neurol ; 17(1): 2, 2021 01.
Article in English | MEDLINE | ID: mdl-33268851
14.
Specific pattern of microglial activation in PD.
Leake, Isobel.
Nat Rev Neurol ; 17(1): 2, 2021 01.
Article in English | MEDLINE | ID: mdl-33268852
15.
Modelling hepato-biliary-pancreatic organogenesis.
Leake, Isobel.
Nat Rev Gastroenterol Hepatol ; 16(12): 706, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31659263
16.
NAFLD and risk of cardiovascular disease.
Leake, Isobel.
Nat Rev Gastroenterol Hepatol ; 16(12): 706, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31659265
17.
Treatment regimen for metastatic colorectal cancer.
Leake, Isobel.
Nat Rev Gastroenterol Hepatol ; 16(12): 706, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31659264
18.
PD-1 inhibitors for oesophageal cancer.
Leake, Isobel.
Nat Rev Gastroenterol Hepatol ; 16(12): 706, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31659266
19.
Unique cellular module identified in Crohn's disease.
Leake, Isobel.
Nat Rev Gastroenterol Hepatol ; 16(11): 648-649, 2019 11.
Article in English | MEDLINE | ID: mdl-31548711

Subject(s)
Crohn Disease , Humans , Single-Cell Analysis , Tumor Necrosis Factor-alpha
20.
Putting the brakes on feeding.
Leake, Isobel.
Nat Rev Neurosci ; 20(9): 513, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31388187
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