ABSTRACT
The authors report the case of a young patient with a tumour of the right atrium and right ventricular outflow tract without visceral complications but with multiple muscular and skin localisations. The diagnosis of tuberculosis was made on biopsy of a suppurating skin lesion. The diagnosis of tuberculosis was made on biopsy of a suppurating skin lesion. Anti-tuberculosis treatment resulted in regression of these tumours, especially the cardiac lesions, confirmed by transoesophageal echocardiography.
Subject(s)
Heart Neoplasms/etiology , Tuberculosis, Cardiovascular/complications , Adult , Antitubercular Agents/therapeutic use , Diagnosis, Differential , Echocardiography, Transesophageal , Follow-Up Studies , Heart Atria/diagnostic imaging , Heart Neoplasms/diagnosis , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/drug therapy , Heart Ventricles/diagnostic imaging , Humans , Male , Radionuclide Imaging , Treatment Outcome , Tuberculosis, Cardiovascular/diagnosis , Tuberculosis, Cardiovascular/drug therapyABSTRACT
The synthesis of some selected PAF-acether homologues with an alkoxy-chain length from C1 to C20 in position 1 is described. All agonist activities are closely correlated among themselves and with the calculated fatty-chain hydrophobicity. After a discussion on recent published results and comparison with our data, we conclude that the ether oxide function is absolutely essential at the glycerol 1-position for potent agonist activity and that potency correlates well with hydrophobicity parameters. We indicate the importance of steric and configurational constraints.
