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1.
Neurosci Behav Physiol ; 37(4): 341-7, 2007 May.
Article in English | MEDLINE | ID: mdl-17457528

ABSTRACT

Studies on rats with experimental diabetes induced by administration of alloxan showed that transcranial electrostimulation of endorphinergic brain structures stimulates the regeneration of damaged beta-cells in pancreatic islets of Langerhans. This was identified on pancreatic sections stained with hematoxylin and eosin. De novo formation of small islets was noted, as evidenced by their regeneration from progenitor cells. After transcranial electrostimulation, islet beta-cells stained by the Gomori method showed recovery of granularity - a sign of insulin production. Application of an immunoenzyme method demonstrated recovery of blood insulin levels, the dynamics of increases in which showed a highly significant negative correlation with a decrease in blood glucose. These data led to the conclusion that the antihyperglycemic effect of transcranial electrostimulation in experimental alloxan diabetes results from reparative regeneration of beta-cells in islets of Langerhans with recovery of their insulin-producing function.


Subject(s)
Diabetes Mellitus, Experimental/pathology , Diabetes Mellitus, Experimental/therapy , Insulin-Secreting Cells/metabolism , Insulin/blood , Nerve Regeneration/drug effects , Transcranial Magnetic Stimulation , Animals , Blood Glucose/metabolism , Disease Models, Animal , Male , Nerve Regeneration/physiology , Rats , Rats, Wistar
2.
Ross Fiziol Zh Im I M Sechenova ; 92(2): 204-13, 2006 Feb.
Article in Russian | MEDLINE | ID: mdl-16739653

ABSTRACT

In alloxan-induced diabetic rats, it was demonstrated that transcranial electrical stimulation of the brain endorphinergic structures activated the reparative regeneration of the damaged beta-cells of the Langerhans pancreatic islets. This was estimated on the histological sections of pancreas with hematoxylin-eosin staining. Several small newborn islets were found to originate from pancreatic progenitor cells. After transcranial electrical stimulation of insulin granules, beta-cells (Gomori's staining) were observed as an indication of the restoration of the insulin production. Correspondingly the increase of the blood insulin level was estimated by immune-enzyme method. The dynamics of the plasma insulin increase had a significant negative correlation with decrease of the blood glucose level. The glucose-lowering action of the transcranial electrical stimulation in alloxan-induced diabetic rats seems to be based on stimulation of the regeneration of damaged beta-cells with the restoration of their insulin production.


Subject(s)
Diabetes Mellitus, Experimental/physiopathology , Insulin-Secreting Cells/physiology , Insulin/blood , Regeneration , Alloxan , Animals , Blood Glucose/analysis , Cerebral Cortex , Electric Stimulation , Male , Rats , Rats, Wistar
7.
Med Tekh ; (6): 32-5, 2002.
Article in Russian | MEDLINE | ID: mdl-12506747

ABSTRACT

The authors evaluated the capacities of transcranial electrostimulation and the specific features of its impact on reparative regeneration of damaged tissues of different types, such as the dermal and gastroduodenal epithelium, hepatic cells, connective tissue, peripheral nerve fibers, on animal experimental pathological models and compared with the results of treatment of respective pathology in patients.


Subject(s)
Brain/physiology , Burns/therapy , Electric Stimulation Therapy , Endorphins/physiology , Hearing Loss, Sensorineural/therapy , Myocardial Infarction/therapy , Peptic Ulcer/therapy , Regeneration/physiology , Adult , Animals , Burns/blood , Child , Electric Stimulation Therapy/instrumentation , Electric Stimulation Therapy/methods , Electrodes , Endorphins/blood , Hearing Loss, Sensorineural/blood , Humans , Liver Regeneration/physiology , Myocardial Infarction/blood , Nerve Regeneration/physiology , Peptic Ulcer/blood , Rats , Time Factors , Wound Healing/physiology
9.
Anesteziol Reanimatol ; (4): 21-3, 2001.
Article in Russian | MEDLINE | ID: mdl-11586623

ABSTRACT

Hemodynamics was studied in 60 patients with pronounced initial hypovolemia, urgently operated on for acute gastrointestinal disease under conditions of 4 anesthesia. In contrast to traditional anesthesia, transcranial electric stimulation (TCES) as a component of anesthesia stabilized hemodynamics without increasing the rate and volume of intraoperative infusion therapy. This makes total anesthesia with TCES preferable in urgent operations, particularly in cases when hypovolemia cannot be properly corrected before surgery.


Subject(s)
Abdomen, Acute/surgery , Anesthesia, General/methods , Hypovolemia/complications , Aged , Electric Stimulation , Emergencies , Humans , Middle Aged , Risk Factors , Time Factors
11.
Ross Fiziol Zh Im I M Sechenova ; 87(10): 1432-49, 2001 Oct.
Article in Russian | MEDLINE | ID: mdl-11767458

ABSTRACT

In randomised blind study with active placebo control in humans, rhythmic photostimulation of 77 Hz frequency did not elicit any fatigue or negative psychophysiological events as opposed to 50, 60, 100 Hz frequency. This and other findings are to be considered in designing rational systems of cinema projection and PC monitors.


Subject(s)
Fatigue/psychology , Adolescent , Adult , Attention , Computers , Fatigue/etiology , Female , Humans , Male , Periodicity , Photic Stimulation , Psychophysiology/methods , Random Allocation , Time Factors
12.
Ross Fiziol Zh Im I M Sechenova ; 86(11): 1449-57, 2000 Nov.
Article in Russian | MEDLINE | ID: mdl-11195212

ABSTRACT

Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its endorphinergic nature. Combined effects of the TES and Essenciale preparation were lower than separate those of these agents. The TES effects were clinically corroborated in treatment of toxic hepatitis.


Subject(s)
Brain/metabolism , Chemical and Drug Induced Liver Injury/metabolism , Endorphins/metabolism , Hepatocytes/metabolism , Animals , Carbon Tetrachloride Poisoning/metabolism , Carbon Tetrachloride Poisoning/pathology , Carbon Tetrachloride Poisoning/physiopathology , Chemical and Drug Induced Liver Injury/pathology , Chemical and Drug Induced Liver Injury/physiopathology , Electric Stimulation , Ethylene Dichlorides , Fatty Liver/pathology , Hepatocytes/pathology , Liver Function Tests , Male , Naloxone/pharmacology , Narcotic Antagonists/pharmacology , Phosphatidylcholines/pharmacology , Protective Agents/pharmacology , Rats , Rats, Wistar
13.
IEEE Trans Biomed Eng ; 46(9): 1139-49, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10493077

ABSTRACT

A magnetic resonance imaging (MRI) method was used for a noninvasive study of current density (CD) and current pathways (CP's) inside the skull during transcranial electrostimulation in rabbits. The transcranial impulse current directions studied were those previously used in transcranial electric treatment either sagittally or bilaterally. MRI data were collected from slices perpendicular to the direction of current application. In these slices, only the perpendicular component of the CD was measured. Computer methods for accurate topographic mapping of the main areas with high CD and for reconstruction of CP's are described. It was revealed that current applied on the head sagittally passed mostly through the cerebrospinal fluid in the basal brain cisternas connected in series, and through the anterior horns of the lateral ventricles, foramina of Monro, ventrocaudal part of the third ventricle, aqueductus, and fourth ventricle. Possible connections between these CP's are suggested. Bilaterally applied current passed through the brain and skull core more diffusely without concentrations in cisternas and ventricles. The results of the present study suggest an explanation for the observation that sagittally applied current more effectively stimulates brain structures with antinociceptive function and elicits more pronounced analgesic effect.


Subject(s)
Brain/anatomy & histology , Brain/physiology , Electrophysiology , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Skull/anatomy & histology , Skull/physiology , Animals , Electric Stimulation , Electrodes , Rabbits
14.
Med Tekh ; (2): 7-13, 1997.
Article in Russian | MEDLINE | ID: mdl-9213744

ABSTRACT

The paper deals with one type of electrostimulation-transcranial electrostimulation (TES). It outlines the physiological mechanisms underlying TES, the clinical features of its application, the equipment performing TES, defines its optimum analgesic mode.


Subject(s)
Electric Stimulation Therapy , Electronarcosis , Transcutaneous Electric Nerve Stimulation , Adult , Animals , Cats , Child , Dogs , Electric Stimulation Therapy/instrumentation , Electric Stimulation Therapy/methods , Electronarcosis/instrumentation , Humans , Mice , Rabbits , Rats , Transcutaneous Electric Nerve Stimulation/instrumentation , Turtles
18.
Fiziol Zh Im I M Sechenova ; 81(10): 36-43, 1995 Oct.
Article in Russian | MEDLINE | ID: mdl-9026257

ABSTRACT

Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. DL-5-hydroxytryptophan and allopurinol enhanced the electroanalgetic effect. The data obtained suggests an existence of a serotoninergic component of the transcranial electroanalgesia mechanism.


Subject(s)
Serotonin/physiology , Transcutaneous Electric Nerve Stimulation , Animals , Electric Stimulation , Male , Pain/etiology , Pain/physiopathology , Pain Management , Rats , Rats, Wistar , Serotonin/cerebrospinal fluid , Serotonin Antagonists/pharmacology , Serotonin Receptor Agonists/pharmacology , Time Factors
20.
Fiziol Zh SSSR Im I M Sechenova ; 78(11): 46-54, 1992 Nov.
Article in Russian | MEDLINE | ID: mdl-1302714

ABSTRACT

The mechanisms of inhibitory effect of transcranial electrostimulation in analgesic regime on blood pressor nociceptive reflexes were studied in experiments in rabbits and cats. Considerable inhibition of the late (bulbar) somato-sympathetic reflexes and spino-bulbo-spinal somato-somatic reflexes as well was demonstrated. The probable basis of sympatho-inhibition during transcranial electrical stimulation is a reduction of excitatory input to bulbar sympathoexcitatory neurons. It was revealed in experiments with inhibition of sympatho-excitation elicited by temporal brain ischaemia and local electrical stimulation of different bulbar ventrolateral vasomotor zones. The role of periaqueductal gray activated by transcranial electrical stimulation as a source of inhibition and its opioid mechanisms are discussed.


Subject(s)
Electronarcosis , Reflex/physiology , Sympathetic Nervous System/physiology , Animals , Cats , Electric Stimulation , Ischemic Attack, Transient/physiopathology , Medulla Oblongata/physiology , Neural Inhibition/physiology , Pressoreceptors/physiology , Rabbits , Reaction Time/physiology , Time Factors
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