ABSTRACT
The aim of the study was an analysis of the frequency of oral steroids prescription to patients with bronchial asthma treated in hospital and of vertebral fractures and deformations as the result of GCS-induced osteoporosis in patients with bronchial asthma taking prednisolone tablets for at least 6 months. The incidence of steroid-dependent bronchial asthma (SDBA) was 12.9%. Roentgenomorphometric analysis of the thoracic and lumbar spine performed in 52 patients with SDBA revealed vertebral fractures in 11(21.1%) patients, deformations of the first and second degree in 25(48.0%) patients. Depressed fractures of the vertebra were the most numerous--14.6%. Males and females had vertebral fractures with similar frequency (21.4 and 20%, respectively). A correlation was found between the number of the affected vertebra and prednisolone treatment duration, total dose.
Subject(s)
Anti-Inflammatory Agents/adverse effects , Asthma/drug therapy , Osteoporosis/chemically induced , Prednisolone/adverse effects , Spinal Fractures/etiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedABSTRACT
The analysis of the prescriptions for bronchial asthma (BA) patients in outpatient practice was made using data base created at the Regional Fund of Obligatory Health Insurance in the Sverdlovsk region with consideration of GINA principles of BA stepped care. The real structure of prescriptions was compared with the pattern drug official list for asthma care. The cost of each BA care step was calculated on the base of the computer programs. The analysis showed low quality of BA care in outpatient practice. The created computer programs are very useful for the prescriptions structure monitoring, cost-effect analysis and pharmacotherapeutical management of the diseases.
