ABSTRACT
Adequately good consumption of beta-carotene was observed in patients with duodenal ulcer and erosive gastritis after daily treatment with 18 mg of the carotinoid used as 0.1% oil solution: concentration of beta-carotene was increased approximately 3-fold in blood serum of these patients. Concentration of retinol was not increased in blood serum after treatment with beta-carotene, thus indicating that the drug treatment was not dangerous. Treatment with beta-carotene led to improvement in the state of the antioxidative system of these patients as resistance of erythrocytes to peroxide hydrolysis was increased while content of malonic dialdehyde was decreased in blood serum. The carotene treatment contributed to arresting pain syndrome in patients with ulcers, to cicatrization of ulcers and to disappearance of gastric mucosal membrane erosion.
Subject(s)
Antioxidants , Carotenoids/administration & dosage , Dietary Fats, Unsaturated , Duodenal Ulcer/blood , Gastritis/blood , Adolescent , Adult , Carotenoids/blood , Carotenoids/therapeutic use , Duodenal Ulcer/drug therapy , Erythrocytes/drug effects , Erythrocytes/metabolism , Female , Gastritis/drug therapy , Humans , Lipid Peroxidation , Male , Malondialdehyde/blood , Middle Aged , Vitamin A/blood , beta CaroteneABSTRACT
The authors report a potentiating effect of sodium glutamate on gastric secretion in subjects free of gastrointestinal diseases. Similar effect has been discovered in dogs. In subjects with gastric hyposecretion (chronic gastritis, functional regulatory disturbances) sodium glutamate combined with pentagastrin is a helpful tool in overall evaluation of gastric secretion. In achlorhydria is can be used for determination of a residual capacity of the stomach to secrete the hydrochloric acid in failure of humoral stimulators.
Subject(s)
Achlorhydria/diagnosis , Gastric Acid/metabolism , Gastric Mucosa/drug effects , Sodium Glutamate/pharmacology , Achlorhydria/drug therapy , Achlorhydria/physiopathology , Adult , Drug Synergism , Gastric Mucosa/metabolism , Humans , Models, Biological , Pentagastrin/administration & dosage , Pentagastrin/pharmacology , Sodium Glutamate/administration & dosage , Sodium Glutamate/therapeutic use , Stimulation, ChemicalABSTRACT
The phenotypic correlations between pepsinogen, proteases and the debit of acid secretion in patients with the peptic ulcer of duodenum and their parents were studied. It was found that the genetic factors have great influence on the level of pepsinogen and proteases in the basal conditions and under stimulation. In comparison with the general population, we obtained highly reliable increase of the level of pepsinogen and proteases in the groups of patients and their parents.
Subject(s)
Duodenal Ulcer/genetics , Gastric Acid/metabolism , Peptide Hydrolases/metabolism , Stomach/enzymology , Adolescent , Adult , Aged , Duodenal Ulcer/enzymology , Female , Gastric Juice/enzymology , Humans , Male , Middle Aged , Pepsinogens/blood , PhenotypeABSTRACT
The research of distribution of blood group ABO, Rhesus, Lewis, Secretor, C5+-component of choline esterase and the ability to taste PTC among Moscow population patients suffering from duodenal ulcer is carried out in comparison with the control. Statistically authentic association of the disease with 0(I) blood group, unsecretor and the association of joint signs (coefficients of association are 1.32, 2.17 and 2.62 respectively) is found. Authenticity of relation with disease is not proved during the investigation of other signs. The values of risk to fall ill for the patients possessing and not possessing the signs of duodenal ulcer are obtained (concerning separate factors and joint factors). It is established that the combination of 0(I) blood group and unsecretor increases the risk of the diseases in 2.4 times as compared with the patients possessing A, B, AB blood groups and secretors.
Subject(s)
Peptic Ulcer/genetics , ABO Blood-Group System/genetics , Antigens/genetics , Cholinesterases/genetics , Duodenal Ulcer/genetics , Genetics, Population , Humans , Lewis Blood Group Antigens/genetics , Moscow , Phenylthiourea , Rh-Hr Blood-Group System/genetics , Taste/drug effectsABSTRACT
Cholesterol, alpha- and beta-lipoproteids, serotonin were determined in the blood serum of dogs which were on atherogenic diet for 2 months. The serotonin content was examined in various parts of the gastrointestinal tract (GIT). Parallel studies of the structural changes were carried out in the vascular system (VS) and various parts of the GIT. There was found a direct correlation between a rise in the cholesterol and serotonin level in the blood and serotonin in the GIT tissues. The initial stages of atherosclerotic changes were revealed in the vascular system. Along with compensatory-adaptive changes detected in the duodenum and the upper protions of the small intestine, initial stages of dystrophic-atrophic processes were observed in the lower portions. Comparative analysis of biochemical and morphological data indicated that disturbances of the morphofunctional state in the GIT played an important role in the genesis of the early stages of atherosclerosis.