[Synthesis and pharmacologic evaluation of 3-(2- and 4-pyridinyl)indane-1,3-diones and structural analogues with potential anti-inflammatory and antineoplastic activity]. / Synthèse et évaluation pharmacologique de 2-(2 et-4-pyridinyl)indane-1,3-diones et d'analogues structuraux à potentialités anti-inflammatoire et antitumorale.

Our on going work in the series of enamido-diketones issued from 2-azaarylindane-1,3-diones led us to synthesize and experiment N and C2-substituted derivatives of 2-(2 and 4-pyridinyl)indane-1,3-diones as well as of structurally related compounds resulting from the replacement of pyridine by quinoline and benzimidazole. Pharmacological evaluation of their anti-inflammatory activity (by inhibition of carrageenan foot edema) and their anticoagulant activity (by prothombin assay) led to the conclusion of the possibility of achieving a selective anti-inflammatory effect. It has been previously established that anticoagulants are liable to exert a protective effect in the development of cancer metastasis. Nevertheless none of the six experimented 2-(pyridin-2-yl)indane-1,3-diones extended survival time of mice treated by P388 lymphocytic leukemia.