1.
J Neuroimmunol
; 355: 577552, 2021 06 15.
Article
in English
| MEDLINE
| ID: mdl-33845282
ABSTRACT
A 43 year-old male presented with a relapsing and progressive systemic inflammatory disorder with central nervous system (CNS) involvement. After a two years follow up, he was diagnosed with hemophagocytic lymphohistiocytosis (HLH), based on clinical, laboratory and radiological findings. Treatment was started with anakinra, a recombinant humanised interleukin-1 (IL-1) receptor antagonist. Clinical response was good. Laboratory and radiological findings showed no disease activity throughout a five years follow-up period. Several immunosuppressive agents have been used in HLH without any good outcomes. This is the first case report of HLH with CNS involvement responsive to chronic treatment with anakinra.
Subject(s)
Brain/diagnostic imaging , Interleukin 1 Receptor Antagonist Protein/administration & dosage , Lymphohistiocytosis, Hemophagocytic/diagnostic imaging , Lymphohistiocytosis, Hemophagocytic/drug therapy , Spinal Nerves/diagnostic imaging , Adult , Brain/drug effects , Brain/metabolism , Follow-Up Studies , Humans , Interleukin 1 Receptor Antagonist Protein/metabolism , Lymphohistiocytosis, Hemophagocytic/metabolism , Male , Receptors, Interleukin-1/agonists , Receptors, Interleukin-1/metabolism , Recurrence , Spinal Nerves/drug effects , Spinal Nerves/metabolism , Treatment Outcome
2.
J Clin Rheumatol
; 20(1): 45-6, 2014 Jan.
Article
in English
| MEDLINE
| ID: mdl-24356482