ABSTRACT
Cancers of unknown primary site constitute a heterogeneous group having in common their biological behaviour. We have analysed patients with cancer of unknown primary site admitted to University Hospital of Coimbra/Internal Medicine Service III from 1st January of 1992 to 30th June of 1998. The study included 26 patients corresponding to a prevalence of 2.5% malignant neoplasias; the median age of affected patients was 64 years old with a male-to-female ratio of 4.2:1. The most frequent histological type was well differentiated and moderately well differentiated adenocarcinoma, 46.1% of all cases. Three years global survival rate was 3.9%. The herein-reported prevalence is comparable to that found in recent literature, showing a good diagnostic skill. As expected, the prognosis was poor, revealing the disease's aggressiveness and the lack of efficient therapy in the majority of case.
Subject(s)
Neoplasms, Unknown Primary , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Neoplasms, Unknown Primary/diagnosis , Neoplasms, Unknown Primary/therapy , Retrospective StudiesSubject(s)
Abdominal Muscles , Abdominal Neoplasms/secondary , Adenocarcinoma/secondary , Laparoscopy/adverse effects , Laparotomy , Pancreatic Neoplasms/pathology , Pancreatic Neoplasms/surgery , Abdominal Neoplasms/surgery , Adenocarcinoma/surgery , Aged , Humans , Laparotomy/adverse effects , Male , Neoplasm SeedingSubject(s)
Cholecystectomy, Laparoscopic/adverse effects , Cholelithiasis/surgery , Lung Abscess/etiology , Sepsis/etiology , Cholelithiasis/diagnostic imaging , Debridement , Female , Follow-Up Studies , Humans , Lung Abscess/diagnostic imaging , Lung Abscess/surgery , Male , Middle Aged , Pleural Effusion/diagnostic imaging , Pleural Effusion/etiology , Pleural Effusion/surgery , Sepsis/diagnostic imaging , Sepsis/surgery , Suction , Tomography, X-Ray Computed , UltrasonographyABSTRACT
Von Recklinghausen's Neurofibromatosis is an autosomal dominant disease of variable manifestations. Association with gastrointestinal and hepatobiliary tumours is well documented, most of them being benign neurofibromas. Other tumours, such as leiomyomas, sarcomas, ganglioneuromas and carcinoids are less frequent. Much rarer is the development of epithelial malignancies and an ontogenic relation is not clear. The authors reports a case of adenocarcinoma of Vater's Ampulla and duodenal neurofibromas, in a patient with Von Recklinghausen's disease, presenting obstructive jaundice.
Subject(s)
Adenocarcinoma/diagnosis , Ampulla of Vater , Common Bile Duct Neoplasms/diagnosis , Neoplasms, Multiple Primary/diagnosis , Neurofibromatosis 1/diagnosis , Humans , Male , Middle AgedABSTRACT
The authors describe two cases of the superior mesenteric artery syndrome. The diagnosis was made by radiology and both were treated surgically. They emphasize the most relevant symptoms (epigastric pain and vomiting) and the characteristic radiological signs which permit the diagnosis (marked to-and-fro peristalsis in the duodenum with extrinsic compression of the third part and proximal dilatation ending abruptly). Although the conservative measures are sufficient in most cases, those presented in this paper, both needed surgery.