Polyglandular autoimmune syndrome: current concepts.

The polyglandular autoimmune syndrome (PGAS) is characterized by the association of two or more endocrine disorders that are mediated by autoimmune mechanisms and usually lead to a hypofunctional state. In this review we classify the various types of PGAS and discuss their clinical features and the pathophysiologic autoimmune mechanisms that are thought to play an important role. Circulating organ- and cell-specific autoantibodies are frequently detected in patients with the syndrome and may be a marker of future organ failure. PGAS should be considered in patients with one or more of the disorders constituting the syndrome; this should facilitate early diagnosis and perhaps even prevention of other components of the disease. Early recognition and replacement therapy can be life-saving, particularly when there is adrenal or thyroid insufficiency.

Determinacion rapida y precisa de cifras altas de glucemia con el metodo de dilucion y un reflectometro. / Rapid determination and cipher of high glucose with dilution method and reflectante meter

Los metodos para determinar la glucemia rapidamente a la cabecera del enfermo (tiras reactivas y aparadas de reflexion) no pueden medir mas de 400 mg/dl (22.2 mmol/ 1) de glucosa o carecen de precision. El metodo de dilucion, que consiste en diluir una muestra de sangre capilar, leer la concentracion de glucosa con una tira reactiva y multiplicar el resultado segun la dilucion, logra medir glucemias muy altas, pero la lectura visual es imprecisa. En este trabajo se intenso mejorar la precision con lectura en un reflectometro