[Conjunctivo-corneal complex choristoma. Report of an anatomoclinical study]. / Choristome complexe conjonctivo-cornéen. A propos d'une observation anatomo-clinique.

Complex choristomas are very rare ocular tumors. We report a case of a 3-month-old infant who was referred to us because of a left congenital conjunctivo-corneal protruding mass. Total excision removing 2/3 of the limbus was performed and replaced simultaneously by a limbal autograft. Histopathological examination of the excised choristoma revealed many pilosebaceous follicules in the conjunctival tissue, keratinized epithelium, lacrimal glands, and differentiated cartilage.

[Plasma determination of 7 common drugs by high performance liquid chromatography]. / Dosage plasmatique de sept médicaments usuels par chromatographie liquide haute performance.

A high performance liquid-chromatographic procedure is reported for measuring the plasma concentration of 5 anticonvulsants: phenobarbital, phenytoin, carbamazepine, ethosuximide, valproic acid and 2 bronchodilators: theophylline and caffeine. Limits of detection of ethosuximide and valproic acid are 28 mumol/l, 5 mumol/l for the other drugs. Linearity limits are always very upper than the higher therapeutic dose concentration, the inter assay relative standard deviation are less than 8 p. cent for the 7 drugs at the 3 levels of concentration and the analytical recoveries ranged from 93 to 104 p. cent. The technique is simple and rapid: 4 anticonvulsants are simultaneously extracted and dosed, valproic acid, only has to be dosed lonely. Finally, comparatively to the other immunoassay technique, this method is cheaper.