Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Chem Commun (Camb) ; 46(26): 4680-2, 2010 Jul 14.
Article in English | MEDLINE | ID: mdl-20383387

ABSTRACT

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.


Subject(s)
G-Quadruplexes , Heterocyclic Compounds, 3-Ring/chemistry , Proto-Oncogene Proteins c-myc/genetics , Biological Products/chemistry , Biological Products/pharmacology , DNA/chemistry , Heterocyclic Compounds, 3-Ring/pharmacology , High-Throughput Screening Assays , Ligands , Models, Molecular , Nucleic Acid Conformation
2.
Angew Chem Int Ed Engl ; 49(16): 2860-4, 2010 Apr 06.
Article in English | MEDLINE | ID: mdl-20235259

ABSTRACT

Small but effective: two natural-product-like inhibitors of tumor necrosis factor α (TNF-α; represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule, and display potency comparable to that of the strongest TNF-α inhibitor reported to date.


Subject(s)
Biological Products/pharmacology , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Biological Products/chemistry , Drug Discovery , Humans , Models, Molecular
SELECTION OF CITATIONS
SEARCH DETAIL
...