ABSTRACT
Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
Subject(s)
G-Quadruplexes , Heterocyclic Compounds, 3-Ring/chemistry , Proto-Oncogene Proteins c-myc/genetics , Biological Products/chemistry , Biological Products/pharmacology , DNA/chemistry , Heterocyclic Compounds, 3-Ring/pharmacology , High-Throughput Screening Assays , Ligands , Models, Molecular , Nucleic Acid ConformationABSTRACT
Small but effective: two natural-product-like inhibitors of tumor necrosis factorâ α (TNF-α; represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule, and display potency comparable to that of the strongest TNF-α inhibitor reported to date.
Subject(s)
Biological Products/pharmacology , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Biological Products/chemistry , Drug Discovery , Humans , Models, MolecularABSTRACT
An oligonucleotide-based luminescent platinum(II) switch-on probe has been developed for selective detection of nanomolar Hg(2+) ions.
