Simulation study of alpha-neutron reactions from AmBe directional source using MCNP 6.1.1 with TENDL 2012, 2014, and 2017 libraries.

Angular dependence of 9Be(α, n)12C was simulated in Monte-Carlo N-Particle transport 6.1.1 (MCNP) with TALYS Evaluated Nuclear Data Library (TENDL) 2012, 2014, and 2017 data to determine secondary neutron direction and energy for neutron imaging. The simulations consisted of a 90 µCi 241Am source and a 25 µm thick 9Be target. Neutrons emitted from the 9Be(α, n)12C were collected at different angles of emission within the MCNP simulation, which will be compared to experimental data in the future. The MCNP simulation used alpha induced data obtained through TALYS and processed through NJOY2016 into RECONR and ACER formats. Cross section tables were mapped appropriately in MCNP for the cross-section data to be read. Appropriate source particle weighting was determined for the alpha particles and neutrons, and the results were displayed in the F4 tallies. The total neutron production and neutron spectrum was compared to previous work. Discrepancies between the obtained results and previous work are discussed. Angular and energy dependence of secondary neutrons from TENDL 2012, 2014, and 2017 libraries were found, and will later be compared to experimental results. This work was done to support Patent No: 62/529,583.

Detector response function of an energy-resolved CdTe single photon counting detector.

BACKGROUND: While spectral CT using single photon counting detector has shown a number of advantages in diagnostic imaging, knowledge of the detector response function of an energy-resolved detector is needed to correct the signal bias and reconstruct the image more accurately. OBJECTIVE: The objective of this paper is to study the photo counting detector response function using laboratory sources, and investigate the signal bias correction method. METHODS: Our approach is to model the detector response function over the entire diagnostic energy range (20 keV

X-ray digital industrial radiography (DIR) for local liquid velocity (V(LL)) measurement in trickle bed reactors (TBRs): validation of the technique.

Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V(LL)) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V(LL) within TBRs.

Reduction of a grid moiré pattern by integrating a carbon-interspaced high precision x-ray grid with a digital radiographic detector.

The stationary grid commonly used with a digital x-ray detector causes a moiré interference pattern due to the inadequate sampling of the grid shadows by the detector pixels. There are limitations with the previous methods used to remove the moiré such as imperfect electromagnetic interference shielding and the loss of image information. A new method is proposed for removing the moiré pattern by integrating a carbon-interspaced high precision x-ray grid with high grid line uniformity with the detector for frequency matching. The grid was aligned to the detector by translating and rotating the x-ray grid with respect to the detector using microcontrolled alignment mechanism. The gap between the grid and the detector surface was adjusted with micrometer precision to precisely match the projected grid line pitch to the detector pixel pitch. Considering the magnification of the grid shadows on the detector plane, the grids were manufactured such that the grid line frequency was slightly higher than the detector sampling frequency. This study examined the factors that affect the moiré pattern, particularly the line frequency and displacement. The frequency of the moiré pattern was found to be sensitive to the angular displacement of the grid with respect to the detector while the horizontal translation alters the phase but not the moiré frequency. The frequency of the moiré pattern also decreased with decreasing difference in frequency between the grid and the detector, and a moiré-free image was produced after complete matching for a given source to detector distance. The image quality factors including the contrast, signal-to-noise ratio and uniformity in the images with and without the moiré pattern were investigated.

Development of a rapid planning technique based on heuristic target shaping for stereotactic radiosurgery.

Stereotactic radiosurgery (SRS) is a technique to delivering a high dose to a target region and a low dose to a critical organ by using only one or a few irradiations. Traditionally, SRS is performed using a Gamma knife with using 201 cobalt 60 sources or a linear accelerator with equally spaced noncoplanar arcs. Finding a specific condition that includes the target in the prescription dose while sparing the critical organ is tedious, because there are many combinations of positions and collimator sizes for each isocenter. Many methods of identifying suitable planning condition automatically have been proposed. However, there are some limitations using these methods. These include a long calculation time to obtain the final plan, and difficulties finding a unique solution due to different tumor shapes. This study uses three steps to solve these problems. (1) The dose distribution of one isocenter is modeled as a sphere. This makes it possible to reduce the time needed to obtain the result due to the absence of a dose calculation. (2) The target was constructed by piling up cylinders along a virtual axis, which was the longest line in a given target. (3) Spheres were then packed in each cylinder according to the position and diameter of each cylinder in order to cover each target divided by the height of the cylinder. The results of applying three imaginary targets were found to be satisfactory in terms of: target coverage-more than 50%, the reproducibility of the result and the calculation time-several tens of seconds. The PITV ratio was less than 2.0. However, the dose applied to normal tissue around the target must be reduced slightly. Planner or conventional optimization algorithms might easily solve this limitation.

Proton MR spectroscopic changes in Parkinson's diseases after thalamotomy.

To investigate whether there are significant changes in regional brain metabolism in patients with Parkinson's disease before and after thalamotomy using proton magnetic resonance spectroscopy (1H MRS). Fifteen patients underwent 15 stereotactic thalamotomies for control of medically refractory parkinsonian tremor. Single-voxel 1H MRS was carried out on a 1.5 T unit using stimulated-echo acquisition mode (STEAM) sequence (TR/TM/TE, 2000/14/20 ms). Spectra were obtained from substantia nigra, thalamus and putamen areas with volumes of interests (7-8 ml) in patients before and after the surgery. Metabolite ratios of NAA/Cho, NAA/Cr and Cho/Cr were calculated from relative peak area measurements. We evaluated alterations of metabolite ratios in brain metabolism in Parkinson's disease patients with clinical outcome following thalamotomy. NAA/Cho ratios showed generally low levels in substantia nigra and thalamus in Parkinson's disease patients with clinical improvement following thalamotomy. In 80% (12/15) patients, decreased NAA/Cho ratios were observed from the selected voxels in substantia nigra after thalamic surgery (P<0.05). The ratios were also significantly decreased in thalamus in 67% (10/15) patients with clinical improvement (P<0.05). Our results suggest that NAA/Cho ratio may be a valuable criterion for evaluation of Parkinson's disease patients with the clinical improvement following surgery. 1H MRS may be a useful utility for the aid in better understanding the pathophysiologic process in Parkinson's disease patients on the basis of the variation of NAA/Cho ratio.

Feasibility of proton chemical shift imaging with a stereotactic headframe.

To prove feasibility of proton chemical shift imaging ((1)H CSI) during stereotactic procedure, authors performed (1)H CSI in combination with a stereotactic headframe and selected targets according to local metabolic information, evaluated the pathologic results. The (1)H CSI directed stereotactic biopsy was performed in four patients. (1)H CSI and conventional Gd-enhancement stereotactic MRI were performed simultaneously after the fitting of a stereotactic headframe. Focal areas of increased phosphocholine(Cho)/phosphocreatine(Cr) and Lactate/Cr ratios were selected as target sites in the stereotactic MR images. (1)H CSI is possible with the stereotactic headframe in place. Pathologic samples taken from areas of increased Cho/Cr ratios and decreased NAA/Cr ratios provided information upon increased cellularity, mitoses and cellular atypism, and facilitated diagnosis. Pathologic samples taken from areas of increased Lac/Cr ratio showed predominant feature of necrosis. (1)H CSI was feasible with the stereotactic headframe in place. The final pathologic results obtained were concordant with the local metabolic information from (1)H CSI. We believe that (1)H CSI-directed stereotactic biopsy has the potential to significantly improve the accuracy of stereotactic biopsy targeting.

Metabolic alterations in Parkinson's disease after thalamotomy, as revealed by 1H MR spectroscopy.

OBJECTIVE: To determine, using proton magnetic resonance spectroscopy (1H MRS) whether thalamotomy in patients with Parkinson's disease gives rise to significant changes in regional brain metabolism. MATERIALS AND METHODS: Fifteen patients each underwent stereotactic thalamotomy for the control of medically refractory parkinsonian tremor. Single-voxel 1H MRS was performed on a 1.5T unit using a STEAM sequence (TR/TM/TE, 2000/14/20 msec), and spectra were obtained from substantia nigra, thalamus and putamen areas, with volumes of interest of 7-8 ml, before and after thalamotomy. NAA/Cho, NAA/Cr and Cho/Cr metabolite ratios were calculated from relative peak area measurements, and any changes were recorded and assessed. RESULTS: In the substantia nigra and thalamus, NAA/Cho ratios were generally low. In the substantia nigra of 80% of patients (12/15) who showed clinical improvement, decreased NAA/Cho ratios were observed in selected voxels after thalamic surgery (p < 0.05). In the thalamus of 67% of such patients (10/15), significant decreases were also noted (p < 0.05). CONCLUSION: Our results suggest that the NAA/Cho ratio may be a valuable criterion for the evaluation of Parkinson's disease patients who show clinical improvement following surgery. By highlighting variations in this ratio, 1H MRS may help lead to a better understanding of the pathophysiologic processes occurring in those with Parkinson's disease.