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Antimicrob Agents Chemother ; 55(11): 5380-3, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21844322

ABSTRACT

We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.


Subject(s)
Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Escherichia coli/drug effects , Pseudomonas aeruginosa/drug effects
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