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Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.
Chang, Kai-Hsuan; Lee, Lenselot; Chen, Jessica; Li, Wen-Shan.
Chem Commun (Camb) ; (6): 629-31, 2006 Feb 14.
Article in English | MEDLINE | ID: mdl-16446832

ABSTRACT

A new type of noncompetitive alpha-2,3-sialyltransferase inhibitor has been synthesized; we report the discovery, preparation and inhibitory activity of sixteen lithocholic acid analogues.


Subject(s)
Enzyme Inhibitors/chemical synthesis , Lithocholic Acid/chemical synthesis , Sialyltransferases/antagonists & inhibitors , Catalysis , Enzyme Inhibitors/pharmacology , Lithocholic Acid/analogs & derivatives , Lithocholic Acid/pharmacology , Models, Chemical , Sialic Acids/chemistry
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