Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses.

PURPOSE: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and a new high dynamic range (HDR) system. MATERIALS AND METHODS: One monofocal, 1 extended depth of focus, and 4 multifocal IOLs were evaluated. An off-the-shelf optical bench was used to simulate a distant (>50 m) car headlight and record images. A custom HDR system was constructed using an imaging photometer to simulate headlight images and to measure quantitative halo luminance data. A metric was developed to characterize halo luminance properties. Clinical relevance was investigated by correlating halo measurements to visual outcomes questionnaire data. RESULTS: The Optikos system produced halo images useful for visual comparisons; however, measurements were relative and not quantitative. The HDR halo system provided objective and quantitative measurements used to create a metric from the area under the curve (AUC) of the logarithmic normalized halo profile. This proposed metric differentiated between IOL models, and linear regression analysis found strong correlations between AUC and subjective clinical ratings of halos. CONCLUSION: The HDR system produced quantitative, preclinical metrics that correlated to patients' subjective perception of halos.

Optical bench performance of a novel trifocal intraocular lens compared with a multifocal intraocular lens.

PURPOSE: The purpose of this study is to compare the optical characteristics of the novel PanOptix presbyopia-correcting trifocal intraocular lens (IOL) and the multifocal ReSTOR +3.0 D IOL, through in vitro bench investigations. METHODS: The optical characteristics of AcrySof(®) IQ PanOptix™ (PanOptix) and AcrySof(®) IQ ReSTOR +3.0 D (ReSTOR +3.0 D) IOLs were evaluated by through-focus Badal images, simulated headlight images, and modulation transfer function (MTF) measurements which determine resolution, photic phenomena, and image quality. Through-focus Badal images of an Early Treatment of Diabetic Retinopathy Study chart were recorded at both photopic and mesopic pupil sizes. Simulated headlight images were taken on an MTF bench with a 50-µm pinhole target and a 5.0 mm pupil at the distance focus of the IOL. MTF curves were measured with a 3.0 mm pupil, and spatial frequencies equivalent to 20/40 and 20/20 visual acuities were recorded to illustrate the through-focus MTF curves. Far-, intermediate-, and near-focus MTF values were obtained. RESULTS: Bench Badal image testing and MTF measurements showed that PanOptix has a near focus at a distance of 42 cm and an additional intermediate focus at a distance of about 60 cm. The near focus for ReSTOR +3.0 D is at 45 cm. PanOptix and ReSTOR +3.0 D have comparable photopic distances and near MTF values. Additionally, PanOptix provided a substantial continuous range of vision from distance to intermediate and to near compared with ReSTOR +3.0 D. The halo propensity for PanOptix was slightly higher than that for ReSTOR +3.0 D. CONCLUSION: Laboratory-based in vitro simulations showed that PanOptix trifocal IOL has comparable resolution and image quality performance in distance and near foci compared with ReSTOR +3.0 D IOL. PanOptix showed better resolution and image quality performance at the intermediate focus than ReSTOR +3.0 D IOL.

eXtreme chirped pulse oscillator operating in the nanosecond stretched pulse regime.

An eXtreme Chirped Pulse Oscillator (XCPO) implemented with a Theta cavity and based on a semiconductor optical amplifier (SOA) is presented for generating 10 ns frequency-swept pulses and 3.6 ps compressed pulses directly from the oscillator. In this experiment, we show the two distinct characteristics of the XCPO which are the scalability of the output energy and the mode-locked spectrum. By using these characteristics, we obtain a pulse energy of 58.4 pJ from the stretched pulse and a mode-locked optical bandwidth of 14.6 nm (10 dB) directly from the oscillator. The laser cavity design allows for low repetition rate operation <100 MHz, as well. The cavity, significantly, reduces nonlinear carrier dynamics, integrated self phase modulation (SPM), and fast gain recovery in an SOA. Due to the laser's ability to generate directly frequency-swept pulses from the oscillator, this oscillator can be used for high speed frequency-swept optical coherence tomography (OCT) and time-stretched photonic analog to digital converters (P-ADC).

Pulse-amplitude equalization by negative impulse modulation for rational harmonic mode locking.

We propose a novel technique based on negative impulse modulation for pulse repetition rate multiplication by rational harmonic mode locking with pulse-amplitude-equalized pulses directly from the laser cavity. We have generated a pulse train of 15 GHz with more than 16 dB suppression of unwanted amplitude modulation spurs by using a 1 GHz RF signal. This is the highest suppression ratio for a repetition rate multiplication factor of 15 to our knowledge.

1.4kW high peak power generation from an all semiconductor mode-locked master oscillator power amplifier system based on eXtreme Chirped Pulse Amplification(X-CPA).

The concept of eXtreme Chirped Pulse Amplification (X-CPA) is introduced as a novel method to overcome the energy storage limit of semiconductor optical amplifiers in ultrashort pulse amplification. A colliding pulse mode-locked semiconductor laser is developed as a master oscillator and generates 600fs pulses with 6nm bandwidth at 975nm. Using a highly dispersive chirped fiber Bragg grating (1600ps/nm) as an extreme pulse stretcher and compressor, we demonstrate ~16,000 times extreme chirped pulse amplification and recompression generating optical pulses of 590fs with 1.4kW of peak power. These pulses represent, to our knowledge, the highest peak power generated from an all semiconductor ultrafast laser system.

External-cavity, actively mode-locked grating-coupled surface-emitting laser and amplification characteristics of a grating-coupled semiconductor optical amplifier.

An external-cavity, actively mode-locked grating-coupled surface-emitting semiconductor laser (GCSEL) is demonstrated for the first time to the authors' knowledge. The mode-locked oscillator generates a train of optical pulses at a 297-MHz pulse-repetition frequency. The optical pulse from the oscillator has a width of 22.6 ps and a spectral bandwidth of 0.07 nm at 975.9 nm, giving a time-bandwidth product of 0.50. In addition, amplification characteristics of a grating-coupled semiconductor optical amplifier are studied with a continuous-wave external-cavity GCSEL.