ABSTRACT
Nine chemicals and commercial disinfectants were tested for inactivation of Aleutian disease virus of mink. In the presence of distilled water, a commercial disinfectant (O-Syl), halogen derivatives (iodophor and sodium hypochlorite), and glutaraldehyde (2.0%) inactivated 4 log10 (based on 0.25 ml) of the virus within 10 minutes at 23 C. Formalin (2.0%) and O-Syl were slower to inactivate the virus, but achieved a 4 log10 reduction in titer by 30 minutes' contact time. In the presence of 10% bovine serum, formalin (1.0%), O-Syl, and sodium hydroxide (0.5%) achieved a 4 log10 reduction within 10 minutes. All agents tested had some virucidal effect.
Subject(s)
Aleutian Mink Disease Virus/drug effects , Disinfectants/pharmacology , Viruses, Unclassified/drug effects , Chlorhexidine/pharmacology , Ethanol/pharmacology , Formaldehyde/pharmacology , Glutaral/pharmacology , Iodophors/pharmacology , Sodium Hydroxide/pharmacology , Sodium Hypochlorite/pharmacology , Water/pharmacologyABSTRACT
Ataxia and depression developed in 21 of 50 (42%) laboratory cats wearing flea collars impregnated with 2,2-dichlorovinyl dimethyl phosphate (dichlorvos or DDVP) in a warm dry environment. Five (10%) of the cats died. Whole blood cholinesterase (ChE) activity was significantly (P smaller than 0.001) reduced in all cats and cervical dermatitis occurred in 37 (74%) of them.
