Limited volume resuscitation in hypotensive elderly multiple trauma is safe and prevents early clinical dilutive coagulopathy -- a matched-pair analysis from TraumaRegister DGU(®).

BACKGROUND: The use of permissive hypotension includes a restrained volume preclinical therapy. However, in the elderly patients, this approach has raised concerns because of the increased cardiovascular risk profile and a higher incidence of hypertension under normal conditions. The aim of the study was to examine whether preclinical administration of restrictive volume therapy in the elderly patient can be safe. PATIENTS AND METHODS: A retrospective matched-pair analysis with the data set of the TraumaRegister DGU(®) (TR-DGU) was performed based on data of 176 pairs of totally 67,000 patients. To address elderly potentially bleeding patients without major brain injury the following inclusion criteria were chosen: patients ≥ 60 years, ISS ≥ 16, AIS head<4, preclinical blood pressure between 60 and 100 mmHg and recorded preclinical volume administration. Patients that met the inclusion criteria (908) were divided into two groups: pre-clinical volume resuscitation ≤ 1000 ml (=low volume) and >1000 ml (high volume). Patients with high- and low-volume fluid replacement were matched according to the following criteria: age group, gender, date of the accident ± 5 years, ISS, GCS, preclinical intubation, ground-/air-transport, pre-clinical blood pressure. RESULTS: Preclinical volume resuscitation showed a difference of about 1000 ml between the "low volume" and "high volume" group. The "low volume" group showed a significantly elongated prothrombin time. The amount of blood products given in the emergency department was not significantly different. The ventilation was 2 days shorter in the "low volume", although the number of patients with severe thoracic trauma was greater in this group. The length of stay in the ICU differed by 3 days in favour of the "low volume" group. The overall mortality was almost the same in both groups. CONCLUSIONS: Based on these data it can be assumed that the lower preclinical volume administration has a positive effect on the initial coagulation status in elderly patients. In spite of some limitations such as low number of matched pairs, we draw the cautious conclusion that a restrictive preclinical volume therapy is safe and also indicated in elderly patients.

[Real-time MRI with radial k-radial scanning technique for control of angiographic interventions]. / Echtzeit-MR mit radialer k-Raumabtastung zur Uberwachung angiographischer Interventionen.

PURPOSE: To test the feasibility of real-time MR controlled guidance of field-inhomogeneity catheters in vitro and in vivo as a first step to MR-guided angiographic interventions. METHODS: Applying a combination of radial scanning with the sliding window reconstruction technique, a frame rate of 23 low resolution images per second was achieved. Field inhomogeneity catheters were steered through a flow phantom and into the renal arteries of a pig. RESULTS: It was possible to visualize flow or, respectively, vessels and to depict catheter movements. This enabled real-time MR-guidance of the catheter into the renal arteries of the flow phantom and into those of the pig. CONCLUSIONS: The new technique yields a sufficiently high temporal resolution for MR-guidance of catheters through vessels.

[Cava filter placement under MRI control. Experimental in vitro and in vivo studies]. / Kavafilterimplantation unter MRT-Kontrolle: Experimentelle In vitro- und In vivo-Untersuchungen.

PURPOSE: An instrument has been developed for the introduction of caval filters which can be used with MRI; it has been investigated in in vitro and in in vivo experiments. MATERIAL AND METHOD: The ferromagnetic components of a commercially available instrument for the femoral introduction of the MR-eye Tulip IVC filter were changed for similar, non-ferromagnetic parts and the lock and dilator marked with dysprosium oxide rings. The instrument was used in a flow phantom and in animal experiments (two domestic pigs) in order to insert filters under MRI control on a 1.5 T Philips Gyroscan with integrated mobile digital subtraction angiography. RESULTS: Both in vitro and in vivo, the introducer, catheter and caval filter could be identified by MRI and positioned under MRI control. The position of the filter as indicated by MRI corresponded with radiological and macroscopic findings in all cases (5 phantoms, 2 pigs). CONCLUSION: The early experimental results indicate that percutaneous introduction of caval filters with placement under MRI control is possible.