Analysis and validation of a 3D finite element model for human forearm fracture.

Most researchers have performed finite element (FE) analysis of the human forearm fracture by exploring the strength and load transmission of the bones. However, few studies concentrated a complete simulation of the whole forearm complex including ligaments. This paper aims to investigate the load transmission through the bones, contact stress at the joints and strain in the ligaments by using an elaborate FE model, further validating the fracture condition for human forearm. The interosseous ligament was separated into three regions based on the distance to the proximal and distal ends. The FE simulation results were slightly more or less than a previous experimental data in the literature, but generally provided a close approximation of the bone and ligament behaviors. Compared with the experiment results under different loading conditions, maximum contact stress at the proximal radio ulnar joint (PRUJ) and distal radio ulnar joint (DRUJ) of the simulations was higher with an average of 13.4%, and peak strain in the interosseous ligament (IOL) was lower with an average of 11.0%. Under 10 kg load, the maximum stress in the radius (2.25 MPa) was less than double the value in the ulna (1.43 MPa). Finally, the FE model has been validated with the onset and location of the Colles' fracture in the literature. This study will provide a great benefit in terms of surgical and medical applications related to forearm fracture that require an extensive knowledge of the behavior of the bones and ligaments under various loading conditions.

Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome.

Aims: Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive. An exceptional case of severe CRPS leading to forearm amputation provided the opportunity to examine nerve histopathological features of the peripheral nerves. Methods: A 35-year-old female developed CRPS secondary to low voltage electrical injury. The CRPS was refractory to medical therapy and led to functional loss of the forelimb, repeated cutaneous wound infections leading to hospitalization. Specifically, the patient had exhausted a targeted conservative pain management programme prior to forearm amputation. Radial, median, and ulnar nerve specimens were obtained from the amputated limb and analyzed by light and transmission electron microscopy (TEM). Results: All samples showed features of selective myelinated nerve fiber degeneration (47-58% of fibers) on electron microscopy. Degenerating myelinated fibers were significantly larger than healthy fibers (p < 0.05), and corresponded to the larger Aα fibers (motor/proprioception) whilst smaller Aδ (pain/temperature) fibers were spared. Groups of small unmyelinated C fibers (Remak bundles) also showed evidence of degeneration in all samples. Conclusions: We are the first to show large fiber degeneration in CRPS using TEM. Degeneration of Aα fibers may lead to an imbalance in nerve signaling, inappropriately triggering the smaller healthy Aδ fibers, which transmit pain and temperature. These findings suggest peripheral nerve degeneration may play a key role in CRPS. Improved knowledge of pathogenesis will help develop more targeted treatments.

Impact of Long Flexor Versus Intrinsic Dominance in the Generation of Arc of Finger Flexion.

Background: Finger flexion is a composite movement involving both long flexors and intrinsic hand muscles. Previous studies have characterized this but have not investigated differences within the normal population. Were discrete finger motion patterns identified, this could guide rehabilitation programs following flexor tendon surgery. Methods: Twelve volunteers repeatedly flexed and extended at a comfortable speed, resting their hand on a horizontal surface. Video was recorded perpendicular to the little finger flexion plane, and the little finger tip position was identified frame by frame to create a composite curve. Its highest point was noted, and the horizontal distance was measured from this point to the palmar digital crease (ΔXH). Results: In addition, 2 investigators independently reviewed frame-by-frame images and allocated subjects into groups based on the motion pattern. ΔXH demonstrated 2 clusters within our study population, and there was a statistically significant (P < .036) difference between groups. Conclusions: This study demonstrated that qualitative and quantitative differences exist in flexion curves between individuals.

Anatomic Relationships of the Distal and Proximal Radioulnar Joints Articulating Surface Areas and of the Radius and Ulna Bone Volumes - Implications for Biomechanical Studies of the Distal and Proximal Radioulnar Joints and Forearm Bones.

BACKGROUND: Previous work from this laboratory has evidenced the biomechanical role of forearm osseoligamentous structures in load transfer of applied forces. It has shown that forces transmitted across the distal radioulnar joint (DRUJ) and proximal radioulnar joint (PRUJ) are similar, though not identical, under axial loading conditions. The purpose of the study was to assess the articulating surface areas of the radioulnar joints and the volumes of the forearm bones addressing the hypothesis that there may be anatomic adaptations that reflect the biomechanical function of the integrated forearm unit. METHODS: The articulating surface areas of PRUJ and DRUJ were assessed using a laser scanner in 24 cadaver forearms. The articulating joint surfaces were additionally delineated from standardized photographs assessed by three observers. The surface areas of matched pairs of joints were compared on the null hypothesis that these were the same within a given forearm specimen. An additional 44 pairs of matched forearm bone volumes were measured using water displacement technique and again compared through statistical analysis (paired sample t-test and Bland-Altman analysis). RESULTS: The findings of this study are that the articulating surface areas of the DRUJ and PRUJ as well as the bone volumes are significantly different and, yet, strongly correlated. The paired sample t-test showed a significant difference between the surface areas of the DRUJ and PRUJ (p < 0.05). The PRUJ articulating surface area was marginally larger than the DRUJ with a PRUJ:DRUJ ratio of 1.02. Paired sample t-test showed a significant difference between the two bone volumes (p < 0.01) with a radius to ulna bone volume ratio of 0.81. When the olecranon was disregarded, radius volume was on average of 4% greater than ulna volume. CONCLUSION: This study demonstrates and defines the anatomical relationships between the two forearm bones and their articulating joints when matched for specimen. The data obtained are consistent with the theory of integrated forearm function generated from published biomechanical studies.

The Effect of Elbow Extension on the Biomechanics of the Osseoligamentous Structures of the Forearm.

PURPOSE: To investigate the hypothesis that elbow extension alters the biomechanics of forearm rotation including force transmission in the distal and proximal radioulnar joints (DRUJ and PRUJ) and the interosseous ligament (IOL). METHODS: A cadaver model with a custom-designed jig was used to measure forearm pronosupination ranges, transmitted forces and contact areas across the PRUJ and DRUJ, and tension in the 3 main components of the IOL's central band. Testing with applied loads was undertaken throughout pronosupination with the elbow fully flexed (n = 15) and fully extended (n = 11). RESULTS: Elbow extension-flexion affected the range of forearm pronosupination, shifting the arc of rotation such that the forearm supinated maximally with the elbow flexed and pronated maximally with the elbow extended. Elbow extension also increased transmitted forces across the DRUJ and PRUJ while also increasing contact areas within the DRUJ and PRUJ. Elbow extension significantly increased tension in the central band of the IOL when the forearm was maximally pronated. CONCLUSIONS: Maximum supination occurred with the elbow flexed. Maximum pronation occurred with it extended. Elbow position altered forearm biomechanics, including force transmission across the PRUJ and DRUJ and transmitted tension in the IOL. CLINICAL RELEVANCE: The interplay of osseoligamentous forearm structures is such that we would anticipate surgical alteration of any one of them to have effects upon function of the others.

Adipose-derived stem cells: selecting for translational success.

We have witnessed a rapid expansion of in vitro characterization and differentiation of adipose-derived stem cells, with increasing translation to both in vivo models and a breadth of clinical specialties. However, an appreciation of the truly heterogeneous nature of this unique stem cell group has identified a need to more accurately delineate subpopulations by any of a host of methods, to include functional properties or surface marker expression. Cells selected for improved proliferative, differentiative, angiogenic or ischemia-resistant properties are but a few attributes that could prove beneficial for targeted treatments or therapies. Optimizing cell culture conditions to permit re-introduction to patients is critical for clinical translation.

Sonographic measurements of longitudinal median nerve sliding in patients following nerve repair.

Nerve sliding may be restricted following nerve repair. This could result in increased tension across the repair site and lead to poor functional recovery of the nerve. Ultrasound was used to examine longitudinal median nerve sliding in 10 patients who had previously undergone nerve repair surgery following complete division of the median nerve. The median longitudinal movement in the forearm in response to metacarpophalangeal (MCP) joint movements was 2.15 mm on the injured side, compared with 2.54 mm on the uninjured side, a difference that was significant. There was a significant reduction in nerve sliding following repair (median = 8%, range -8% to 54%; P = 0.02), which correlated with time from injury to surgery (rho = 0.87; P = 0.001). These results indicate that ultrasound can be used as an adjunct assessment tool to monitor both morphology and sliding of the nerve through the repair site. It may have future application in the investigation of patients with persisting functional impairment following primary nerve repair.

Dynamic skin tension in the forearm: effects of pronation and supination.

PURPOSE: Longitudinal scars on the radial quadrant of the distal forearm skin envelope are typically observed to be wider than those on the ulnar quadrant and have an increased incidence of hypertrophic change. Forearm rotation movements may produce differential skin tensions within the forearm skin envelope, and this may lead to differential scarring patterns. This study was designed to measure skin tension changes in the forearm as a result of rotational position to see if these would be consistent with the hypothesis that greater tension changes are observed on the radial aspect of the forearm. METHODS: The effect of forearm position on the magnitude and direction of skin tension was measured on human volunteers. Standardized circles were marked in circumferential fashion at specified intervals on forearm skin, and the angular and dimensional distortion of these circles that occurred with forearm rotation was measured with caliper and goniometer. Data were analyzed for statistical significance using paired t-test. RESULTS: Pronation and supination resulted in marked angular rotation of the lines of maximal skin tension at all sites on the forearm. Supination resulted in a greater angular deviation of the lines of maximal skin tension from the longitudinal line of usual surgical incision, particularly on the radial aspect of the forearm. In supination, the magnitude of ellipsoid deformation at the distal forearm was greater on the radial aspect compared with that of the ulnar. Similar significant changes were also demonstrated at the mid-forearm and proximal forearm levels. CONCLUSIONS: This study systematically maps the effects of pronation and supination on skin tension within the forearm skin envelope. The significant changes occurring in both the ellipsoid deformation and ellipsoid orientation support our hypothesis that the magnitude of skin tension changes significantly with forearm rotation. The radial aspect of the distal forearm experiences the greatest changes, particularly as the forearm supinates.

The functional anatomy of forearm rotation.

The elbow, forearm and wrist act as a unified structure to provide a stable, strong and highly mobile strut for positioning the hand in space and for conducting load-bearing tasks. An understanding of the relevant anatomy and biomechanics is important for the surgeon assessing and treating disorders of forearm function. This paper is concerned with illuminating the principles and concepts governing forearm rotation and load-bearing functions.

The distal radioulnar joint as a load-bearing mechanism--a biomechanical study.

PURPOSE: A biomechanical study was performed to define the normal profiles of force transmission across the distal radioulnar joint (DRUJ) and their alteration as the result of surgical modification of the joint and its ligaments. METHODS: Twelve cadaver arms were used in this investigation. A custom-made jig was designed to hold the arm and allow axial loading of the hand. Force transmitted across the DRUJ was measured with sensor film. The axial force transmitted through the ulna and radius was measured with strain gauges mounted to the surface of each bone and the strain in the dorsal and volar distal radioulnar ligaments (DRUL) was measured with differential variable reluctance transducers. Measurements of force and strain with the DRUJ in the surgically unmodified condition were performed in various positions of forearm rotation and with sequential loads. Subsequently, the same series of measurements was performed after DRUL division and after reconstruction of the ligament. The effect of excision of the ulna head (Darrach's procedure) was also studied. RESULTS: Force varied significantly (p <.05) with the applied load and with forearm position, being greater in supination than pronation (sensor film data). Force transmitted through the ulna varied in an approximately reciprocal pattern with that of the radius. The greatest forces through the ulna occurred in supination and therefore mirrored the change in force transmission across the DRUJ. Between 32% and 34%, respectively, of the applied load (5-10 kg) was transmitted through the ulna and the remainder was transmitted through the radius (strain gauge data). Division of either the volar or the dorsal DRUL tended to increase the force transmitted across the DRUJ (p =.09), and reconstruction of the disrupted DRUL restored the force pattern toward the previous values (not significant) (differential variable reluctance transducer data). Excision of the ulna head disrupted the force transmission profiles, producing the biomechanical equivalent of a 1-bone forearm. Only 1.8% and 2.7% of the applied force (10 kg and 5 kg), respectively, was transmitted through the ulna (strain gauge data only). CONCLUSIONS: The data show consistent and characteristic force transmission profiles across the DRUJ and through both ulna and radius. The joint is important in the transmission of load and its anatomic integrity should be respected in surgical procedures if normal biomechanics are to be preserved.

The pulley system of the thumb: anatomic and biomechanical study.

To examine the precise conformation of the annular and oblique pulleys of the thumb flexor sheath, anatomic dissections were undertaken on 14 hands. In all specimens a distinct pulley was found between the A1 and oblique pulleys. This is named the variable annular pulley or Av pulley. There appear to be 3 discrete forms of this pulley designated type I to III. The biomechanical study was done on 8 limbs by using linear strain transduction techniques. The analysis showed that the strain in the oblique pulley was greater in extension than in flexion of the thumb. This statement remains true even after division of either the A1 or Av pulley and after section of both pulleys. The oblique pulley does not prevent bowstringing of the flexor pollicis longus when A1 and Av pulleys have been sectioned. These studies challenge current concepts of both the anatomy and mechanics of the thumb pulley system with implications for clinical procedures such as trigger thumb release and pulley reconstruction.