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1.
Physiol Biochem Zool ; 95(1): 15-21, 2022.
Article in English | MEDLINE | ID: mdl-34813413

ABSTRACT

AbstractIn ectotherms, it is well described that thermal acclimation induces compensatory adjustments maintaining mitochondrial functions across large shifts in temperature. However, until now, studies mostly focused on fluxes of oxygen without knowing whether mitochondrial efficiency to produce ATP (ATP/O ratio) is also dependent on temperature acclimation. We thus measured thermal reaction norms of oxidative phosphorylation activity and efficiency in isolated mitochondria from skeletal muscle of sea bass (Dicentrarchus labrax) juveniles acclimated at optimal (22°C), low (18°C), and high (26°C) temperatures. The mitochondrial fluxes (oxygen consumption and ATP synthesis) increased with increasing assay temperatures and were on the whole higher in fishes acclimated at 18°C than in the other two groups. However, these mitochondrial rates were not significantly different between experimental groups when they were compared at the acclimation temperature. In contrast, we show that acclimation to high, and not low, temperature improved mitochondrial efficiency (on average >15%). This higher efficiency in high-temperature-acclimated fishes is also apparent when compared at respective acclimation temperatures. This mitochondrial phenotype would favor an economical management of oxygen in response to harsh energetic constraints associated with warming water.


Subject(s)
Bass , Oxygen , Acclimatization , Animals , Mitochondria , Oxygen Consumption , Temperature
2.
Ecotoxicol Environ Saf ; 225: 112720, 2021 Dec 01.
Article in English | MEDLINE | ID: mdl-34509163

ABSTRACT

The last remaining population of European sturgeon (Acipenser sturio) lives in the Gironde-Garonne-Dordogne (France) catchment (GGD). Captive young individuals are released into the GGD hydrosystem each year, as part of a restocking programme. This study aims to assess the health status of juveniles A. sturio to current conditions in the GGD hydrosystem, to evaluate their capacity to survive and grow in a moderately anthropized ecosystems. 3-month-old farmed sturgeons were exposed for one month in experimental conditions that mimic the environmental conditions in the Garonne and Dordogne rivers, followed by five months of depuration. After one month of exposure, fish exposed to Dordogne and Garonne waters bioaccumulated higher levels of metals and persistent organic pollutants, displayed a reduced hepato-somatic index, and had depleted levels of lipids and glycogen content in their liver, when compared with the Reference group. However, metabolic and swimming performance, as well as the costs of swimming were not impaired. After the 5 months depuration, a significant decrease of K was observed for all exposure conditions. HSI also decreased with time. The overall health status and adaptive capacity of juvenile A. sturio appeared to be maintained over the experimental 6 months' period. Juveniles of A. sturio seem to have the adaptive capacity to survive and grow in the GGD hydrosystem, after being released as part of a restocking programme.


Subject(s)
Persistent Organic Pollutants , Rivers , Animals , Ecosystem , Fishes , Humans , Infant , Metals
3.
Ecotoxicol Environ Saf ; 132: 145-52, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27318196

ABSTRACT

Depending on their origins, polycyclic aromatic hydrocarbons (PAH) are characterized by different chemical properties. Petrogenic PAH (e.g. from fossil fuels) and pyrolytic PAH (e.g. those produced by incineration processes) are therefore expected to affect organisms differently. The impact of trophic exposure to these PAH was investigated on swimming and metabolic performance of zebrafish Danio rerio. Two-month-old juveniles and six-month-old adults were individually challenged following a swimming step protocol. While pyrolytic exposure did not affect fish whatever the duration of exposure, it appeared that petrogenic PAH impaired adults' performance. Indeed, the active metabolic rate in petrogenic PAH-contaminated adults was significantly reduced by 35%, and critical swimming speed by 26.5%. This was associated with cardiac abnormalities, which are expected to contribute to the reduction of oxygen transport, particularly during intensive effort. These results may be due to the different composition and toxicity of PAH mixtures.


Subject(s)
Polycyclic Aromatic Hydrocarbons/toxicity , Swimming , Water Pollutants, Chemical/toxicity , Zebrafish/physiology , Adolescent , Animals , Eating , Fossil Fuels , Heart Defects, Congenital/chemically induced , Humans , Incineration , Zebrafish/abnormalities , Zebrafish/metabolism
4.
J Fish Biol ; 88(1): 433-42, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26768980

ABSTRACT

The effect of trophic exposure to pyrolitic polycyclic aromatic hydrocarbons (PAH) on aerobic metabolism of zebrafish Danio rerio was investigated. There were no significant differences in standard metabolic rate (SMR), active metabolic rate (AMR) or aerobic metabolic scope (AS) at any sublethal concentration of PAH in the diet of adult or juvenile fish. This suggests that under these experimental conditions, exposure to PAH in food did not influence aerobic metabolism of this species.


Subject(s)
Environmental Exposure/adverse effects , Polycyclic Aromatic Hydrocarbons/adverse effects , Water Pollutants/adverse effects , Zebrafish/metabolism , Animals , Energy Metabolism , Oxygen Consumption
5.
J Fish Biol ; 84(4): 1171-8, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24628562

ABSTRACT

The relationship between body mass (M) and metabolic rate was investigated through the assessment of active (R(A)) and standard (R(S)) metabolic rate at different life stages in zebrafish Danio rerio (5 day-old larvae, 2 month-old juveniles and 6 month-old adults). Scaling exponents and constants were assessed for standard (R(S) = 0·273M(0·965) in mgO(2) g(-1) h(-1)) and active metabolic rate (R(A) = 0·799M(0·926) in mgO(2) g(-1) h(-1)). These data provide the basis for further experiments regarding the effects of environmental factors on aerobic metabolism throughout the life cycle of this species.


Subject(s)
Body Size , Oxygen Consumption , Zebrafish/metabolism , Animals , Larva/growth & development , Larva/metabolism , Zebrafish/growth & development
6.
Aquat Toxicol ; 127: 54-60, 2013 Feb.
Article in English | MEDLINE | ID: mdl-22682372

ABSTRACT

Coastal habitats play a major role as nurseries for many fish species; however, they are also submitted to pollutants and oxygen fluctuations. Fry's concept of metabolic scope for activity was used to evaluate the effect of polychlorinated biphenyls (PCBs) on the aerobic metabolism in juvenile common sole (0-1 year old). Aerobic metabolic scope (AMS) in control and PCB-contaminated fish via food pathway was determined using respirometry techniques. Furthermore, the hypoxia tolerance in control and PCB-contaminated fish was evaluated by assessing their critical oxygen concentration (O(2crit)). Our results showed that while PCB-contaminated fish were able to maintain a constant AMS and O(2crit), PCBs tend to affect their aerobic metabolism by acting on maximal oxygen consumption (MO(2max)) in hypoxia and standard metabolic rate, but only at the highest PCB concentration between 30 and 60 days of exposure. In conclusion, we can hypothetise that the tested PCB-exposures may not impair the tolerance to hypoxia and the survival of common sole in their natural environment.


Subject(s)
Energy Metabolism/drug effects , Environmental Exposure , Flatfishes/metabolism , Polychlorinated Biphenyls/toxicity , Water Pollutants, Chemical/toxicity , Aerobiosis/drug effects , Animals , Liver/drug effects , Oxygen/metabolism
7.
J Fish Biol ; 80(7): 2636-42, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22650439

ABSTRACT

Ventilation frequency (F(V) ) in motionless common sole Solea solea was measured before and after a startling stimulus in normoxia and in hypoxia (15% air saturation). Startling reduced F(V) in normoxia (from mean ±s.e. 41 ± 3·3 beats min⁻¹ to near zero, i.e. 2·0 ± 1·8 beats min⁻¹) and in hypoxia (from mean ±s.e. 80 ± 4·4 to 58·8 ± 12·9 beats min⁻¹). It is suggested that the maintenance of high F(V) in hypoxia may increase the probability of detection by predators compared to normoxia.


Subject(s)
Flatfishes/physiology , Hypoxia/veterinary , Animals , Hypoxia/pathology , Respiration
8.
J Fish Biol ; 75(7): 1615-25, 2009 Nov.
Article in English | MEDLINE | ID: mdl-20738637

ABSTRACT

The hypothesis of a differential effect of hypoxia on activity in shoaling v. solitary fish was tested in golden grey mullet Liza aurata. In both solitary and shoaling fish, (1) swimming activity increased significantly at

Subject(s)
Hypoxia/physiopathology , Smegmamorpha/physiology , Swimming/physiology , Animals , Oxygen/metabolism
9.
Philos Trans R Soc Lond B Biol Sci ; 362(1487): 2105-21, 2007 Nov 29.
Article in English | MEDLINE | ID: mdl-17472921

ABSTRACT

Hypoxia is a phenomenon occurring in marine coastal areas with increasing frequency. While hypoxia has been documented to affect fish activity and metabolism, recent evidence shows that hypoxia can also have a detrimental effect on various antipredator behaviours. Here, we review such evidence with a focus on the effect of hypoxia on fish escape responses, its modulation by aquatic surface respiration (ASR) and schooling behaviour. The main effect of hypoxia on escape behaviour was found in responsiveness and directionality. Locomotor performance in escapes was expected to be relatively independent of hypoxia, since escape responses are fuelled anaerobically. However, hypoxia decreased locomotor performance in some species (Mugilidae) although only in the absence of ASR in severe hypoxia. ASR allows fish to show higher escape performance than fish staying in the water column where hypoxia occurs. This situation provides a trade-off whereby fish may perform ASR in order to avoid the detrimental effects of hypoxia, although they would be subjected to higher exposure to aerial predation. As a result of this trade-off, fishes appear to minimize surfacing behaviour in the presence of aerial predators and to surface near shelters, where possible. For many fish species, schooling can be an effective antipredator behaviour. Severe hypoxia may lead to the disruption of the school unit. At moderate levels, hypoxia can increase school volume and can change the shuffling behaviour of individuals. By altering school structure and dynamics, hypoxia may affect the well functioning of schooling in terms of synchronization and execution of antipredator manoeuvres. School structure and volume appear to be the results of numerous trade-offs, where school shape may be dictated by the presence of predators, the need for energy saving via hydrodynamic advantages and oxygen level. The effects of hypoxia on aquatic organisms can be taxon specific. While hypoxia may not necessarily increase the vulnerability of fish subject to predation by other fish (since feeding in fish also decreases in hypoxia), predators from other taxa such as birds, jellyfish or aquatic mammals may take advantage of the detrimental effects of hypoxia on fish escape ability. Therefore, the effect of hypoxia on fish antipredator behaviours may have major consequences for the composition of aquatic communities.


Subject(s)
Behavior, Animal/physiology , Fishes/physiology , Hypoxia/veterinary , Animals , Escape Reaction/physiology , Hypoxia/physiopathology , Motor Activity/physiology , Population Dynamics
10.
J Liposome Res ; 11(2-3): 229-42, 2001.
Article in English | MEDLINE | ID: mdl-19530935

ABSTRACT

Liposomes are potential candidates in Human nutrition to supplement diets in essential lipo- and hydro-soluble nutriments. In this context, marine lipid based-vesicles, rich in polyunsaturated fatty acids, and containing vitamin B1 (thiamine) were prepared. Two methods were envisaged for vitamin trapping, passive encapsulation and active loading through the use of a transmembrane pH gradient. These methods were compared in terms of thiamine trapping efficiency. Influence of xanthan addition was also studied. Although, the active loading yielded to higher encapsulation ratios than the passive method, encapsulation efficiency was markedly increased, in both cases, as soon as the hydrocolloid was added after the lipid hydration phase. Liposome stability was assayed by microscopy observation and membrane permeability to thiamine in a medium that mimic that faced by the structures administrated by the oral route, i.e., an acid pH medium, as in the Human stomach. Low pH value led to an instantaneous vesicle aggregation. Thiamine was totally released from liposomes prepared without xanthan after 24 h storage in a neutral medium. This time was shortened to 1 h at pH 1.5. However, thiamine retention was significantly improved when liposomes were prepared in presence of the hydrocolloid, whatever the encapsulation method used. On the whole, these results were interpreted in terms of xanthan coating around the liposome surface that would result from lipid-hydrocolloid interactions occurring during the centrifugation steps of liposome preparation.

11.
Allergy ; 54 Suppl 58: 13-6, 1999.
Article in English | MEDLINE | ID: mdl-10735643

ABSTRACT

Some adverse reactions to iodinated contrast material (ICM) are considered allergy-like, with cutaneous, cardiovascular, respiratory, and digestive symptoms. Allergy-like reactions are usually unpredictable. Reactions are more frequent with ionic than with nonionic material, but the frequency of deaths is almost identical. In a recent study, 20 severe unexpected reactions to ICM, including 10 life-threatening reactions and one death, were investigated by measuring mediators in blood, within the first minutes or hours of reaction. The responsible ICMs were mostly ionic materials. Histamine and tryptase release correlated with the severity of the reaction. Specific IgE against the responsible ICM was significantly higher in reactors than in controls. A few patients had positive skin tests to the administered ICM, suggesting type-I allergic reaction. Only 2.4% and 3.1% of the cases yielded a positive IgE-RIA, in a second retrospective study which included 165 patients recruited during a 4-year period. In conclusion, IgE-mediated anaphylaxis is rare, but it may be one of the possible mechanisms of severe adverse reactions to ICM.


Subject(s)
Anaphylaxis/chemically induced , Contrast Media/adverse effects , Iodine/adverse effects , Anaphylaxis/metabolism , Chymases , Histamine Release , Humans , Immunoglobulin E/analysis , Iodine/immunology , Serine Endopeptidases/metabolism , Skin Tests , Tryptases
12.
Ann Fr Anesth Reanim ; 16(8): 978-81, 1997.
Article in French | MEDLINE | ID: mdl-9750649

ABSTRACT

The authors report a case of a 76-year-old man, with not past history of abnormal bleeding, who suffered an acute, recurrent, intestinal haemorrhage from extensive angiodysplasia of the colon. Intestinal bleeding and angiodysplasia were associated with a von Willebrand's disease. Genetic analysis showed a point mutation in arginine 611 of the mature von Willebrand's factor subunit (A1 loop) confirming a von Willebrand's disease type 2.


Subject(s)
Angiodysplasia/diagnosis , Gastrointestinal Hemorrhage/etiology , von Willebrand Diseases/diagnosis , Aged , Angiodysplasia/complications , Colon/blood supply , Diverticulum, Colon/complications , Humans , Male , Mutation, Missense , Pedigree , Recurrence , von Willebrand Diseases/blood , von Willebrand Diseases/classification , von Willebrand Diseases/complications , von Willebrand Diseases/genetics
13.
Brain Inj ; 10(5): 367-75, 1996 May.
Article in English | MEDLINE | ID: mdl-8735666

ABSTRACT

A modified Delphi technique was used to obtain group consensus among 31 rehabilitation professionals (RPs) from nine rehabilitation centres throughout the province of Québec (Canada) to ascertain their expert opinion on the health risk factors (HRF) to be verified prior to beginning an exercise programme or evaluation for patients with traumatic brain injury (TBI). From the initial survey 87 items were generated, which were later regrouped into 27 HRFs. The relative importance of each HRF in regard to being screened before exercise in a population with TBI was then assessed by each RP using a five-point ordinal scale (1 = not important to 5 = extremely important). HRFs that were considered extremely important by at least 50% of HPs include: angina pectoris, aortic stenosis, exertional syncope, musculoskeletal sequelae which are exacerbated by exercise, outward aggressivity, pulmonary embolism, uncontrolled epilepsy (seizures), and ventricular arrhythmias. Professionals involved in exercising patients with TBI may find these factors useful to the efficient conduct of their rehabilitation programme.


Subject(s)
Brain Injuries/rehabilitation , Exercise/physiology , Patient Care Team , Physical Fitness/physiology , Adult , Brain Injuries/physiopathology , Delphi Technique , Female , Humans , Male , Middle Aged , Physical Examination , Risk Factors
14.
Eur J Pediatr Surg ; 5(2): 113-5, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7612580

ABSTRACT

The case of an eleven-months-old girl is reported: she entered the intensive care unit for fever, vomiting and left pleural effusion. Abdominal echography, CT scan and colonic opacification led to the diagnosis of a colonic Bochdalek hernia. A review of the literature showed that colonic hernias are rare, with only five previous reported cases in which colon was found in the thorax. The authors emphasise that there is a high risk of misdiagnosis due to the fact that small intestine contrast studies are normal; only colonic contrasting may lead to the right diagnosis. The roles of echography and CT scan are discussed.


Subject(s)
Colon/abnormalities , Hernia, Diaphragmatic/diagnosis , Hernias, Diaphragmatic, Congenital , Diagnostic Errors , Female , Hernia, Diaphragmatic/diagnostic imaging , Humans , Infant , Tomography, X-Ray Computed , Ultrasonography
15.
Br J Anaesth ; 74(4): 430-7, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7734264

ABSTRACT

In order to achieve a correct diagnosis of drug anaphylaxis using a radioimmunoassay devoid of interferences, we have studied factors leading to false positive or false negative values of plasma histamine. Different steps in sample collection were studied systematically in 30 normal volunteers. False positive values were found in haemolysed samples, with histamine concentrations being correlated with haemoglobin concentrations, and where plasma was aspirated from the white-cell layer. There was no significant increase when a tourniquet or vacuum tubes were used, or when blood tubes were left at 4 degrees C overnight. In 12 patients who experienced an anaphylactic reaction, histamine disappeared from blood 10 times more slowly than expected. False negative values were found in two pregnant women and one heparinized patient. Histamine was remarkably stable in vitro in blood or plasma samples, whereas it disappeared rapidly when plasma from a pregnant woman or a heparinized patient was added to the sample. We conclude that false positive and false negative values are rare when using this radioimmunoassay.


Subject(s)
Histamine/blood , Radioimmunoassay/methods , Adolescent , Adult , Anaphylaxis/blood , Blood Specimen Collection , False Negative Reactions , False Positive Reactions , Female , Hemoglobins/analysis , Hemolysis , Humans , Male , Middle Aged , Pregnancy , Temperature
16.
Arch Dis Child Fetal Neonatal Ed ; 72(1): F3-7, 1995 Jan.
Article in English | MEDLINE | ID: mdl-7743281

ABSTRACT

Between 1988 and 1992, 18 mechanically ventilated newborn babies (mean weight 1300 g and gestational age 30 weeks) presented with deteriorating respiratory failure at a mean age of 29 days. All developed increased oxygen requirements, hypoxic and hypercapnic episodes, and radiological changes of fixed lobar emphysema or recurrent atelectasis which sometimes changed sides from one day to another. Tracheobronchography with iopydol-iopydone was normal in five (27%) cases, but in 13 showed tracheobronchial stenosis localised to the lower trachea (seven cases), to the right main bronchus (three cases), or including the left main bronchus (four cases). Eleven of these 13 patients underwent endoscopy and balloon dilatation of the stenotic area. Five patients died, one before endoscopy, one immediately after endoscopies, and three subsequently with severe bronchopulmonary dysplasia. The other six babies recovered without any sequelae after balloon dilatation.


Subject(s)
Bronchial Diseases/therapy , Catheterization , Respiration, Artificial , Tracheal Stenosis/therapy , Bronchial Diseases/diagnostic imaging , Bronchography , Endoscopy , Female , Gestational Age , Humans , Infant, Newborn , Male , Recurrence , Respiratory Insufficiency , Tracheal Stenosis/diagnostic imaging
17.
Arch Pediatr ; 1(5): 470-6, 1994 May.
Article in French | MEDLINE | ID: mdl-7951831

ABSTRACT

BACKGROUND: The effects of volume expansion on the cardiac output (CO) of newborns have not been studied, so that the indications for colloid infusion are not well standardized. POPULATION AND METHODS: Twenty one newborns (14 preterm and seven term babies) were studied before the 7th day of life. Thirteen had patent ductus arteriosus (PDA) and six had ischemic cardiopathy. Hemodynamic data indicated that these babies should be given 20 ml/kg of a 10% albumin solution. Pulsed-wave Doppler echocardiography was performed before and after infusion. RESULTS: Only 11 newborns had initial low Co (less than 260 ml/kg/min in patients with PDA; less than 200 ml/kg/min in the others). The increases in CO (31 +/- 25% vs 7 +/- 11%, P < 0.01) and of mean aortic flow velocity (MAFV) (34.6 +/- 19.5% vs 7.2 +/- 6.1%, P < 0.01) were significantly greater in this group. The increases in mean arterial pressure (+4 +/- 5 mmHg) and CO (+20 +/- 18%) were significant (P < 0.01) for all patients, both premature and term (with or without PDA and ischemic cardiopathy). The increase in CO was correlated with the initial CO and the cutaneous refilling time but was not correlated with the increase in arterial pressure. The sizes of the ventricles and left atrium grew significantly but that of the right atrium did not. Analysis of the increase in stroke volume in terms of the end diastolic diameter of the left ventricle indicated that the cardiac reserves varied according to the Starling relation. CONCLUSION: Evaluation of MAFV and CO plus diagnosis of PDA are all needed in order to assess whether volume expansion is accurate or not, since, clinical data obtained during the neonatal period are insufficient to do this.


Subject(s)
Albumins/administration & dosage , Cardiac Output , Echocardiography, Doppler , Cardiac Volume , Ductus Arteriosus, Patent/diagnostic imaging , Ductus Arteriosus, Patent/physiopathology , Humans , Infant, Newborn , Myocardial Ischemia/diagnostic imaging , Myocardial Ischemia/physiopathology
18.
Ann Fr Anesth Reanim ; 13(2): 182-94, 1994.
Article in French | MEDLINE | ID: mdl-7818202

ABSTRACT

Eighteen patients with an acute thrombosis of the splanchnic veins were reviewed. Most of apparently idiopathic cases of splanchnic vein thrombosis are related to an increased coagulation related to a congenital or acquired defect of haemostasis. The aim of this study was to assess the effects of a new and effective treatment. Nine male and 9 female patients (range of age: 19 to 81 years) experienced a mesenteric venous thrombosis. There were 14 mesenteric vein thromboses with infarction, two transient mesenteric venous ischaemias without bowel infarction and two acute thromboses of the splanchnic veins without bowel ischaemia. A coagulopathy was detected in seven patients: oral contraception, protein C (PC) or antithrombin III (AT III) congenital deficiencies, acquired deficiency of AT III, PC and protein S (PS), polycythaemia in the post-partum period and primary myeloproliferative disorder. No coagulopathy was associated with thrombosis in eight cases: mesenteric haematoma, splenomegaly, cirrhosis, appendicectomy, cholescytectomy, chronic heart failure, treatment with beta-adrenergic receptor antagonist and digitalis, stenosis of the portal anastomosis after liver transplantation. Twelve patients required surgery: eight intestinal bowel resections with immediate anastomosis, four resections without immediate anastomosis. Only one patient underwent a second look for a repeat bowel resection. No death occurred in the early postoperative period and 17 out of 18 patients were alive after 12 years. An oral anticoagulant therapy was undertaken from two months to seven years. However, three patients suffered a recurrent thrombosis. Two of them required a long-term anticoagulation. Six patients experienced a portal hypertension and oral anticoagulants were discontinued in three of them because of bleeding oesophageal varices. Six patients were treated only by unfractionated heparin (UFH) or low molecular weight heparin (LMWH) followed by oral anticoagulants. After laparotomy, two were only treated with UFH without any bowel resection, as mesenteric venous ischaemia was too extensive. These observations suggest that the choice between an appropriate medical or surgical treatment is important and must be discussed. Since 1989, the therapeutic choice has been modified by ultrasonography and contrast enhanced computed tomographic scan which confirms diagnosis, allows to follow up and check the effects of anticoagulation and to choose the time for surgery. When the diagnosis is established and the patient's risk is low, the IU . kg(-1) . d(-1) to obtain an antifactor Xa activity between 0.3 and 0.6 antiXa IU mL(-1). When the diagnosis is uncertain and the patient's risk if high a laparotomy is required.(ABSTRACT TRUNCATED AT 400 WORDS)


Subject(s)
Mesenteric Vascular Occlusion/etiology , Thrombosis/etiology , Adult , Aged , Aged, 80 and over , Anticoagulants/therapeutic use , Antithrombin III/analysis , Blood Coagulation Disorders/complications , Female , Humans , Male , Mesenteric Vascular Occlusion/epidemiology , Mesenteric Vascular Occlusion/therapy , Mesenteric Veins , Middle Aged , Protein C Deficiency , Protein S Deficiency , Risk Factors , Thrombosis/epidemiology , Thrombosis/therapy , Vitamin K/antagonists & inhibitors
19.
Ann Fr Anesth Reanim ; 13(5 Suppl): S161-8, 1994.
Article in French | MEDLINE | ID: mdl-7778805

ABSTRACT

Surgery of oesophagus carcinoma is a long and major procedure. Perioperative radiochemotherapy is often required. Therefore many factors favour the occurrence of local and general postoperative infection, justifying an antibiotic prophylaxis directed against oesophageal and gastric flora. In case of oesophageal stenosis, the oesophageal floral often switches to the fecal type. Antimicrobial agents diffuse to the surgical site and reach there high concentrations for the time of surgery. We recommend, just prior the induction of anaesthesia the intravenous administration of a single dose of a third generation cephalosporin (ceftriaxone 2 g) and nitroimidazole (ornidazole 1 g). The long half-life of these agents allows sufficient concentrations at surgical site to be obtained and the efficacy of this regimen has been demonstrated. Selective decontamination of the digestive tract with systemic antibiotherapy is another approach for the prevention of postoperative complications of surgery of oesophagus carcinoma.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Esophagus/surgery , Surgical Wound Infection/prevention & control , Anti-Bacterial Agents/administration & dosage , Drug Therapy, Combination/therapeutic use , Esophageal Diseases/surgery , Esophageal Neoplasms/surgery , Esophagus/microbiology , Humans , Premedication
20.
Pediatrie ; 48(3): 205-9, 1993.
Article in French | MEDLINE | ID: mdl-8393976

ABSTRACT

The dead newborns and stillborns of a French department (Ille et Vilaine, préfecture: Rennes) were studied during a 3 year period by a multidisciplinary physician group. There were 128 newborns and 207 stillborns among whom autopsies were carried out in 90 (72%) and 107 (52%) respectively. The contribution of the autopsies to diagnosis was highly different in the two groups: 92% in newborns and 34% in the stillborns. In the stillborns, autopsy was only contributive when congenital malformations were observed, whereas it was not when the cause of the death was obstetrical. We conclude that an autopsy must be performed in all dead newborns and stillborns; however for stillborns complementary investigations must be added, particularly on the placenta.


Subject(s)
Autopsy/statistics & numerical data , Fetal Death/epidemiology , Infant Mortality , Female , Fetal Death/pathology , France/epidemiology , Humans , Infant, Newborn , Pregnancy
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