[Standardization of propolis extract and identification of principal constituents]. / Standardisation d'un extrait de propolis et identification des principaux constituants.

Preparation of a propolis extract was codified, conditions of pulverization, extraction and treatment of the extractive solution are specified. The wounds healing properties of this extract are related to flavonoids and phenolic acids, which were identified by TLC.

[Oral freeze-dried forms of procyanidins]. / Mise au point de lyophilisats oraux de procyanidines.

Oral freeze-dried forms based on procyanidins were prepared. Effort was focused on the choice of the binder and the determination of the optimal conditions of freeze-drying.

[Propolis extract. I. Acute toxicity and determination of acute primary cutaneous irritation index]. / Extrait de propolis: I. Etude de la toxicité aiguë et détermination de l'indice d'irritation primaire cutanée.

In first part, the aim of this work is to study the orally subacute toxicity of a propolis extract on conscious mice. LD50 is more than 7.34 g/kg propolis extract: this product is not toxic. In second part, cutaneous primary irritation of several products: excipients and propolis extract alone or in ointments, is evaluated in the rabbit. The cutaneous reactions after reiterated applications for 14 days are observed. The index of cutaneous primary irritation is calculated by evaluation of the erythematous and oedematous lesions. The propolis extract is non irritant.

[Propolis extract. II. Wound healing the the rat and rabbit]. / Extrait de propolis: II. Etude de la cicatrisation de plaies chez le lapin et chez le rat.

This work is related to wounds healing properties of a propolis extract. In first study on the Albinos Rabbit, the activity of a propolis extract is compared with these of a Peru balsam. Optimal concentrations of them in ointments are evaluated by applications on deep cutaneous scarifications. In order to go further into details, we have chosen in second part, another assay on the Rat, allowing the obtention of deeper wounds; By this way, more complete quantification of retained parameters and a better appraising of the wounds healing process evolution are possible.