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1.
QJM ; 108(3): 183-7, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25086107

ABSTRACT

BACKGROUND: People with severe obesity (body mass index [BMI] > 40 kg/m(2)) have an 85% higher mortality than people with a healthy BMI. Poor physical function may contribute to this excess mortality. Lymphoedema-like swelling can affect the legs of severely obese people with normal lymphoscintigraphy. AIM: We sought to determine the relationship between the presence of lymphoedema-like swelling and physical function in the severely obese. DESIGN AND METHODS: In people with severe obesity, we ascertained whether lower leg lymphoedema-like swelling was present and determined the circumference of the lower leg, time taken to ascend and descend a 17-cm step 50 times and time taken to walk 500 m. RESULTS: The 330 participants, 33% of whom were male, were aged 43.4 ± 12.7 years (mean ± standard deviation) and had a BMI of 51.7 ± 8.4 kg/m(2). Lymphoedema-like swelling was present in approximately one-third (n = 108) in whom a prior history of cellulitis and venous thromboembolism was more common (relative risks 6.16 and 3.86, respectively) than in those without lymphoedema-like swelling. Participants with lymphoedema-like swelling, compared with non-affected counterparts, had a higher lower leg circumference (35.0 ± 7.1 vs. 32.4 ± 4.8 cm), a slower step speed (0.40 ± 0.12 vs. 0.43 ± 0.10 steps/s) and a slower walking speed (0.97 ± 0.37 vs. 1.08 ± 0.30 m/s, P < 0.05 for all comparisons). CONCLUSIONS: In this cross-sectional study, 33% of our severely obese participants had lymphoedema-like swelling. Participants with lymphoedema-like swelling had worse physical function than those without. This association was independent of BMI. The presence of obesity-related chronic lymphoedema-like swelling should lead to interventions that improve physical function.


Subject(s)
Lymphedema/etiology , Obesity, Morbid/complications , Walking/physiology , Adolescent , Adult , Aged , Body Mass Index , Chronic Disease , Cross-Sectional Studies , Exercise Tolerance/physiology , Female , Humans , Leg , Lymphedema/physiopathology , Male , Medical History Taking/methods , Middle Aged , Obesity, Morbid/physiopathology , Physical Examination/methods , Young Adult
2.
Colorectal Dis ; 11(8): 882-3, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19175641

ABSTRACT

We present a case report involving an unusual type of volvulus. A 51-year-old man presented with an acute abdomen. He underwent emergency laparotomy at which we identified a volvulus involving his caecum to descending colon in continuity. We believe this to be first reported case of total colonic volvulus.


Subject(s)
Colectomy , Colonic Diseases/diagnosis , Ileostomy , Intestinal Volvulus/diagnosis , Intestinal Volvulus/surgery , Colonic Diseases/surgery , Humans , Male , Middle Aged
3.
Thorac Cardiovasc Surg ; 53(3): 180-3, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15926101

ABSTRACT

A 62-year-old female patient with known mitral-valve prolapse for the previous five years presented with progressive dyspnea and intermittent palpitations. This clinical presentation was investigated by two-dimensional echocardiography which revealed moderate mitral regurgitation due to a pedunculated mass oscillating between the left atrium and the left ventricle. Successful operative treatment consisted of en-bloc resection of the tumor from the anterior mitral valve leaflet and its primary cords and subsequent reconstruction of the mitral valve. Pathohistological examination revealed a cystic lymphangioma originating from mitral-valve tissue. To our knowledge this is the first reported case in the literature.


Subject(s)
Heart Neoplasms/complications , Lymphangioma, Cystic/complications , Mitral Valve Prolapse/etiology , Female , Heart Neoplasms/pathology , Humans , Lymphangioma, Cystic/pathology , Middle Aged
4.
Nat Cell Biol ; 3(9): 771-7, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11533655

ABSTRACT

Anaphase in budding yeast is triggered by cleavage of the central subunit, Scc1, of the chromosomal cohesin complex by the protease separase. Here we show that separase also cleaves the kinetochore-associated protein Slk19 at anaphase onset. Separase activity is also required for the proper localization of a stable Slk19 cleavage product to the spindle midzone in anaphase. The cleavage and localization of Slk19 are necessary to stabilize the anaphase spindle, and we show that a stable spindle is a prerequisite for timely exit from mitosis. This demonstrates the cleavage of targets other than cohesin by separase in the orchestration of high-fidelity anaphase.


Subject(s)
Cell Cycle Proteins/metabolism , Cell Cycle/physiology , Cell Division/physiology , Endopeptidases , Microtubule-Associated Proteins/genetics , Microtubule-Associated Proteins/metabolism , Saccharomyces cerevisiae Proteins , Saccharomyces cerevisiae/cytology , Saccharomyces cerevisiae/genetics , Amino Acid Sequence , Anaphase/physiology , Binding Sites , Cell Cycle Proteins/chemistry , Cell Cycle Proteins/genetics , Chromosomal Proteins, Non-Histone , Kinetics , Kinetochores/physiology , Mitosis/physiology , Molecular Sequence Data , Nuclear Proteins , Phosphoproteins , Saccharomyces cerevisiae/metabolism , Separase , Sequence Alignment , Sequence Homology, Amino Acid
5.
Phys Rev B Condens Matter ; 48(9): 6550-6555, 1993 Sep 01.
Article in English | MEDLINE | ID: mdl-10009208
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