1.
Postgrad Med J
; 68(798): 289-90, 1992 Apr.
Article
in English
| MEDLINE
| ID: mdl-1409197
ABSTRACT
A 69 year old woman was treated with sotalol (320 mg daily) for intermittent atrial fibrillation. Sotalol was initially well tolerated and reversion to sinus rhythm with sinus bradycardia occurred 4 weeks after initiation of therapy. Shortly thereafter, the patient developed recurrent syncope due to torsade de pointes. This was treated successfully with intravenous magnesium infusion and withdrawal of sotalol. Subsequently, the atrial fibrillation was adequately managed using amiodarone, with no recurrence of torsade de pointes. Development of bradycardia associated with reversion to sinus rhythm represents a potential cause of 'late' pro-arrhythmic effects of sotalol.
Subject(s)
Atrial Fibrillation/drug therapy , Sotalol/adverse effects , Torsades de Pointes/chemically induced , Aged , Amiodarone/therapeutic use , Dose-Response Relationship, Drug , Electrocardiography, Ambulatory/drug effects , Female , Humans , Magnesium Sulfate/therapeutic use , Recurrence , Sotalol/therapeutic use , Torsades de Pointes/drug therapy
2.
Aust J Exp Biol Med Sci
; 48(6): 687-90, 1970 Dec.
Article
in English
| MEDLINE
| ID: mdl-5532178
3.
Aust J Exp Biol Med Sci
; 47(6): 747-54, 1969 Dec.
Article
in English
| MEDLINE
| ID: mdl-5377810