ABSTRACT
Two questions regarding findings from the Women's Health Initiative are (1) What is the effect of various hormonal regimens including selective estrogen receptor modulators? and (2) Is the negative effect on cognitive functioning related to the older age (65+ years) of the women? This study addresses these two questions in a short-term randomized trial of the effects of raloxifene versus alendronate on cognition. The study found only one significant interaction where the raloxifene and alendronate group changed differently across the two testing occasions. Hence, raloxifene does not have any impact, positive or negative, on short-term cognitive functioning when compared to alendronate.
Subject(s)
Bone Density Conservation Agents/adverse effects , Cognition/drug effects , Raloxifene Hydrochloride/adverse effects , Aged , Alendronate/adverse effects , Alendronate/therapeutic use , Bone Density Conservation Agents/therapeutic use , Educational Status , Female , Humans , Middle Aged , Neuropsychological Tests , Osteoporosis/drug therapy , Postmenopause , Raloxifene Hydrochloride/therapeutic useSubject(s)
Education, Medical, Continuing/organization & administration , Health Maintenance Organizations/organization & administration , Models, Educational , Practice Patterns, Physicians'/trends , Benchmarking , California , Cost Savings , Education, Medical, Continuing/economics , Group Processes , Pilot Projects , Practice Patterns, Physicians'/standards , Program Evaluation , Quality of Health CareABSTRACT
Persistent infectious polyarthritis caused by Ureaplasma urealyticum in a patient with common variable hypogammaglobulinaemia is described. The patient developed a symmetrical, destructive polyarthritis and tenosynovitis associated with a markedly depressed synovial fluid glucose concentration and characteristic soft tissue abscesses. The ureaplasma organism developed resistance to multiple antibiotics and persisted for five years. The organism was identified repeatedly in many joints by culture, confirmed by DNA hybridisation, and mycoplasma-like structures were shown in synovial tissues by electron microscopy.
Subject(s)
Agammaglobulinemia/complications , Arthritis, Infectious/complications , Mycoplasmatales Infections/microbiology , Ureaplasma/isolation & purification , Adult , Arthritis, Infectious/microbiology , Humans , Male , Microscopy, Electron , Synovial Membrane/microbiology , Ureaplasma/ultrastructureABSTRACT
A slow clotting dysfibrinogen with delayed anodal immunoelectrophoretic mobility and impaired fibrinopeptide A release has been identified in a patient with recurrent portal vein and deep venous thrombosis. Affected family members tested in the initial screening were asymptomatic. The proband's father died of pulmonary embolism at age 44 years and had mesenteric thrombosis at necropsy. The association of a plasma protein abnormality with visceral thrombosis is unusual and has never been observed previously with a dysfibrinogen. The qualitative abnormality is transmitted as an autosomal codominant and is tentatively designated, fibrinogen Irvine.
