Asian dust storms result in a higher risk of the silicosis hospital admissions.

Purpose: Previous studies found that silicosis was majorly associated with occupation-related risks. However, little evidence was available to clarify the relation between Asian dust storm (ADS) and silicosis hospital admissions. This present paper aims to investigate the association between ADS events and hospital admissions for silicosis. Methods: We applied a Poisson time-series regression on the 2000-2012 National Health Insurance Research Database in Taiwan, linking air quality data and ambient temperature data to estimate the impact of ADS on silicosis hospital admissions in the age-specific groups. Results: A total of 2154 hospital admissions were recorded for silicosis in Taiwan, for a daily average number of 0.45. The number rises from 0.43 on a day without ADS to 0.70 on the outbreak day and continues increasing to 0.83 one day after outbreak. Among patients under 45, the effect of ADS appears on the event day as well as several post-event days (lag2-6) at the significant level of p < 0.1. There is also a significant lag effect on post-event day 2 (p < 0.05) for those aged above 74. Conclusion: Asian dust storms do result in a rise of silicosis hospital admissions, particularly for those above 74, those under 45, and for females.

Optical tweezers and Raman spectroscopy for single-cell classification of drug resistance in acute lymphoblastic leukemia.

Laser Tweezers Raman Spectroscopy (LTRS) is a combination of laser tweezers and Raman spectroscopy. It is a physical tool based on the mechanical effects of the laser, which can be used to study single living cells in suspension in a fast and non-destructive way. Our work aims to establish a methodology system based on LTRS to rapidly and non-destructively detect the resistance of acute lymphoblastic leukemia (ALL) cells and to provide a new idea for the evaluation of the resistance of ALL cells. Two specific adriamycin-resistant and parental ALL cells BALL-1 and Nalm6 were included in this study. Adriamycin resistant cells can induce the spectral differences, which can be detected by LTRS initially. To ensure the accuracy of the results, we use the principal components analysis (PCA) as well as the classification and regression trees (CRT) algorithms, which show that the specificity and sensitivity of LTRS are above 90%. In addition, to further clarify the chemoresistance status of ALL cells, we used the CRT models and receiver operating characteristic (ROC) curves which are based on the band data to look for some important bands and band intensity ratios that have strong pointing significance. Our work proves that LTRS analysis combined with multivariate statistical analyses have great potential to be a novel analytical strategy at the single-cell level for rapidly evaluating the chemoresistance status of ALL cells.

Delicately Controlled Polymer Orientation for High-Performance Non-Fullerene Solar Cells with Halogen-Free Solvent Processing.

Molecular orientation in polymer solar cells (PSCs) is a critical subject of investigation that promotes the quality of bulk heterojunction morphology and power conversion efficiency (PCE). Herein, the intrinsic polymer orientation transition can be found upon delicate control over the branching point position of the irregular alkoxy side chain in difluoroquinoxaline-thiophene-based conjugated polymers. Three polymers with branching points at the third, fourth, and fifth positions away from the backbone were synthesized and abbreviated as PHT3, PHT4, and PHT5, respectively. Temperature-dependent absorption behavior manifests the polymer aggregation ability in the order of PHT3 < PHT4 < PHT5. Surprisingly, the polymer orientation transition from typical face-on to edge-on emerged between PHT4 and PHT5, as evidenced by X-ray-scattering analysis. The enhanced face-on crystallinity of PHT4 endowed the o-xylene-processed PHT4:IT-4Cl-based devices with the highest PCE of 13.40%. For PHT5 with stronger aggregation, the related o-xylene-processed PSCs still showed a good PCE of 12.66%. Our results demonstrate that a delicate polymer orientation transition could be realized through a precisely controlled strategy of the side chain, yielding green-solvent-processed high-performance PSCs.

Introducing Siloxane-Terminated Side Chains in Small Molecular Donors for All-Small-Molecule Organic Solar Cells: Modulated Molecular Orientation and Enhanced Efficiency.

In this work, three small molecular donors (SMDs) S35, S35-1Si, and S35-2Si, with 3,5-difluorophenyl-substituted benzodithiophene as the central 2-dimensional unit to combine different numbers of siloxane-terminated side chain, were synthesized for all-small-molecule organic solar cells (ASM-OSCs). The three SMDs showed comparable film absorption peaks at 570 nm and optical band gaps of 1.8 eV. Relative to S35 and S35-1Si with symmetric alkyl side chains and asymmetric side chains on the central unit, respectively, the S35-2Si carrying two symmetric siloxane-terminated side chains displayed largely elevated melting and crystalline temperatures, lowered surface energy, and modulated molecular orientation. The three SMDs possessed edge-on dominated molecular orientations of their neat films; however, a big difference was found for their blend films with nonfullerene acceptor Y6. The S35:Y6 and S35-1Si:Y6 blends exhibited edge-on and face-on bimodal orientations but the S35-2Si:Y6 blend showed pure face-on orientation, indicating quite different donor:acceptor intermolecular interactions. Some large domains existed in the S35:Y6 and S35-1Si:Y6 blends, but could be suppressed by the S35-2Si:Y6 blend, leading to a more balanced charge transport. In ASM-OSCs, the two S35:Y6 and S35-1Si:Y6 active layers showed comparable power conversion efficiencies (PCE) of ∼12% but a much higher efficiency of 13.50% could be achieved with the S35-2Si:Y6 active layer. Our results suggest that the siloxane-terminated side chain is promising to regulate crystalline ability of a SMD, paving a way for high performance ASM-OSCs.