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Molecules ; 18(2): 1653-9, 2013 Jan 28.
Article in English | MEDLINE | ID: mdl-23358323

ABSTRACT

An efficient and direct protocol for the preparation of amidoalkylnaphthols employing a multi-component, one-pot condensation reaction of 2-naphthol, aromatic aldehydes and acetamide or benzamide in the presence of graphite supported perchloric acid under solvent-free conditions is described. The thermal solvent-free procedure offers advantages such as simple work-up, shorter reaction times and higher product yields, and the catalyst exhibited remarkable reactivity and can be recycled.


Subject(s)
Chemistry, Organic/methods , Graphite/chemistry , Naphthols/chemical synthesis , Perchlorates/chemistry , Recycling , Catalysis , Naphthols/chemistry
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