Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Medicine (Baltimore) ; 98(45): e17937, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31702681

ABSTRACT

Magnetic resonance imaging (MRI) has excellent soft tissue resolution, as well as multidirectional and multisequence scanning technology, making it an important supplementary method in the diagnosis of testicular tumor.To explore the utility of preoperative MRI for the differential diagnosis of testicular seminoma and nonseminomatous germ cell tumors (NSGCTs).The medical records from 39 patients with testicular tumors that were examined preoperatively with MRI and treated with urologic surgery at our institution between January 2015 and March 2019 were retrospectively reviewed. Testicular tumors were confirmed by pathology and classified as seminoma (n = 20) or NSGCT (n = 19). Two radiologists analyzed the testicular tumors on preoperative MRI for morphology: multiple nodules or a single mass; presence/absence of a capsule; signal compared to the normal contralateral testicle (isointense, hypointense, hyperintense, or mixed); enhancement; septa; and hemorrhagic or cystic degeneration. Characteristics of seminomas and NSGCT were compared using the Chi-square or Fischer exact test.MRI showed that the majority (95%; 19/20) of seminomas were nodular. There were significant differences in the presence/absence of a capsule (P = .001), T1-weighted imaging (T1WI) signal intensity (P = .047), T2-weighted imaging (T2WI) signal intensity (P < .001), septa (P < .001), and hemorrhagic or cystic degeneration (P < .001) between seminomas and NSGCT.Seminomas were more likely to have no capsule, isointensity on T1WI, hypointensity on T2WI, and had narrow obviously enhanced fibrovascular septa without hemorrhagic or cystic degeneration; NSGCT was more likely to have a capsule, a mainly mixed signal on T1WI and T2WI, most of them had no fibrovascular septa, and hemorrhagic or cystic degeneration was common in malignant NSGCT.This study suggests that preoperative MRI can distinguish seminoma from NSGCT. We propose that preoperative MRI of the scrotum is an effective technique that should be widely adopted for the management of scrotal disease.


Subject(s)
Neoplasms, Germ Cell and Embryonal/pathology , Seminoma/pathology , Testicular Neoplasms/pathology , Adolescent , Adult , Child , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Neoplasms, Germ Cell and Embryonal/diagnostic imaging , Preoperative Period , Retrospective Studies , Seminoma/diagnostic imaging , Testicular Neoplasms/diagnostic imaging , Young Adult
2.
Contrast Media Mol Imaging ; 2018: 6268437, 2018.
Article in English | MEDLINE | ID: mdl-29666564

ABSTRACT

Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES). After neural induction, nestin and NSE (neural markers) were obviously expressed. In vitro MRI showed that the cationic PEG/PEI-modified SPIO nanoparticles could achieve great relaxation performance and favourable longevity. And the ICP-AES quantified the lowest iron content that could be detected by MRI as 1.56~1.8 pg/cell. This study showed that the cationic SPIO could be directly used to label ADSCs, which could then inductively differentiate into nerve and be imaged by in vitro MRI, which would exhibit important guiding significance for the further in vivo MRI towards animal models with neurodegenerative disorders.


Subject(s)
Cell Tracking/methods , Magnetic Resonance Imaging/methods , Magnetite Nanoparticles , Neurons/cytology , Stem Cells/cytology , Adipose Tissue/cytology , Animals , Cations , Cells, Cultured , Neurodegenerative Diseases , Rats , Staining and Labeling/methods
3.
Clin Imaging ; 50: 211-215, 2018.
Article in English | MEDLINE | ID: mdl-29660532

ABSTRACT

OBJECTIVE: To evaluate the utility of findings on ultrasound and magnetic resonance imaging (MRI) for the preoperative diagnosis of testicular epidermoid cysts (TEC). METHODS: The medical records of five patients treated for TEC at our institution between July 2010 and May 2017 were retrospectively reviewed. RESULTS: Imaging revealed a target or onion skin appearance on ultrasonography and MRI. Pathological examinations showed "bread slag-like" materials within the TEC. Lesions failed to demonstrate enhancement after Gd-DTPA injection. CONCLUSION: In the cases of TEC in the current study, accurate diagnosis ensured enucleation of the testicular cyst was performed rather than testicular resection.


Subject(s)
Epidermal Cyst/diagnostic imaging , Magnetic Resonance Imaging , Testicular Diseases/diagnostic imaging , Ultrasonography , Adult , Epidermal Cyst/pathology , Humans , Male , Retrospective Studies , Testicular Diseases/pathology , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...