ABSTRACT
We present a case of a patient with penile squamous carcinoma and unilateral inguinal nodal involvement. Histological sections of the inguinal tumor demonstrated a basaloid (small-cell) squamous carcinoma of the type that arises from modified skin or mucosa. Multiple cutaneous lesions subsequently developed in the ipsilateral lower extremity. Biopsies revealed tumor that had the same histologic appearance as the nodal metastasis but that also showed a smooth and continuous connection with the overlying epidermis. We discuss the significance of this finding and review the pertinent literature.
Subject(s)
Carcinoma, Squamous Cell/secondary , Leg , Penile Neoplasms/pathology , Skin Neoplasms/secondary , Carcinoma, Squamous Cell/pathology , Diagnosis, Differential , Humans , Lymphatic Metastasis , Male , Middle Aged , Skin Neoplasms/pathologyABSTRACT
Twenty-five cases of cytologic preparations from basal cell carcinomas documented by subsequent tissue material were obtained. The cases were retrospectively analyzed to evaluate the frequency of occurrence of various features that could either be helpful or misleading in the diagnosis. These features included peripheral palisading, Bowenoid nuclei, and keratinized cells. Results from the study include the fact that a major criterion for the histologic diagnosis of basal cell carcinoma (peripheral palisading) could seldom be appreciated in the cytology preparations. Large clusters of cells with crowded nuclei were found in every case and thus represent a useful cytologic parameter. However, because of the frequent absence of peripheral palisading, the study suggests there could be diagnostic confusion with lesions of small cell squamous carcinoma.
Subject(s)
Carcinoma, Basal Cell/pathology , Cytodiagnosis , Humans , Metaplasia , Predictive Value of Tests , Retrospective StudiesABSTRACT
Cutaneous larva migrans, or creeping eruption, is an infection caused by certain nematode larvae and, occasionally, fly maggots. After penetrating human skin, the larvae remain in the epidermis and wander aimlessly. The burrows may be intensely pruritic. Systemic reactions may include profound eosinophilia. Oral or topical thiabendazole is effective therapy.
