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1.
Community Ment Health J ; 60(6): 1131-1140, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38546909

ABSTRACT

While some international qualitative research has interviewed people with serious mental illnesses (SMI) about their experiences in the initial months of the COVID-19 pandemic, few US studies have explored their experiences and perspectives as the pandemic has continued. Drawing from disability studies perspectives, this qualitative study conducted in 2022 explored the experiences of people with SMI seeking services at community mental health centers during the COVID-19 pandemic. Fifteen clients who identified as living with an SMI and were clients during March 2020 were interviewed. Using narrative analysis, we identified an overarching tenor of client experiences: feeling left behind by institutions and society. This feeling of being left behind was conceptualized as three themes. As the literature around the COVID-19 pandemic grows and we attempt to integrate it into community mental health policy and practice, it is essential to include the experiences and perspectives of clients with lived experience of SMI.


Subject(s)
COVID-19 , Community Mental Health Centers , Mental Disorders , Qualitative Research , SARS-CoV-2 , Humans , COVID-19/psychology , COVID-19/epidemiology , Male , Female , Mental Disorders/psychology , Mental Disorders/therapy , Adult , Middle Aged , Pandemics , Interviews as Topic , Community Mental Health Services/organization & administration
2.
J Community Psychol ; 50(4): 2013-2030, 2022 05.
Article in English | MEDLINE | ID: mdl-34004038

ABSTRACT

Police are often called to address concerns about people experiencing homelessness, with arrests often resulting from low-level, nonviolent crimes, and violations of minor nuisance ordinances. In Portland, Oregon, advocates lobbied for a new model of emergency response for 911 calls involving unhoused community members and people experiencing behavioral health crises. To ensure the program reflected the needs and perspectives of people experiencing homelessness, teams of researchers, community volunteers, and people with lived experience interviewed 184 people in camps, shelters, and parks. Teams asked unhoused people how the program should be designed, including who the first responders should be, how they should approach individuals in crisis, what resources they should provide, and how they should be trained. This article describes the methods, findings, and recommendations from our collaborative survey process aimed at ensuring that the voices of people experiencing homelessness informed the development of the Portland Street Response pilot program.


Subject(s)
Ill-Housed Persons , Housing , Humans , Law Enforcement , Police , Social Problems
3.
Am J Orthopsychiatry ; 91(2): 208-216, 2021.
Article in English | MEDLINE | ID: mdl-33983770

ABSTRACT

Following deinstitutionalization, services and housing for people with serious mental illnesses (SMI) became concentrated in economically disadvantaged urban centers. As these areas gentrify, affordable housing for people with SMI is increasingly found in nonurban areas. Although nonurban environments provide benefits for the general population, people with SMI living in nonurban areas perceive higher levels of mental illness stigma. Thus, the relationship between perceived stigma and negative outcomes such as high psychological distress and low sense of community may be stronger in nonurban areas. Data collected from 300 adults with SMI living in urban and nonurban areas were analyzed using a moderated regression design. Urbanicity did not moderate the relationships between perceived stigma and negative outcomes. However, associations were found between urbanicity, perceived stigma, sense of community, and psychological distress, supporting the need to address mental illness stigma in all settings. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Subject(s)
Mental Disorders , Social Stigma , Adult , Humans
4.
J Community Psychol ; 49(6): 1787-1805, 2021 08.
Article in English | MEDLINE | ID: mdl-33855725

ABSTRACT

Overall, the retention of people with serious mental illness (SMI) in supportive housing is high. However, some supportive housing settings report average stays of only 15 months, and others report declines in housing retention over time. Many studies report variables associated with supportive housing stability and tenure, but there are few extensive, focused investigations on the subject. Hence, a literature review was conducted to investigate factors associated with supportive housing stability and tenure among people with SMI. The review of the included 28 papers reveals that the factors associated with supportive housing stability and tenure fell into two general categories of individual factors (including psychiatric factors and prior homelessness), and contextual factors (including program characteristics and sense of community and social support). In conclusion, further focus on contextual factors, as well as a potential reframing of individual factors as contextual, may be helpful in addressing issues related to supportive housing stability and tenure for people with SMI.


Subject(s)
Ill-Housed Persons , Mental Disorders , Housing , Humans , Social Support
5.
Psychiatr Rehabil J ; 42(1): 26-31, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30475006

ABSTRACT

OBJECTIVE: This study describes the perspectives of outpatients with serious mental illness (SMI) and alcohol dependence on their participation in a contingency management (CM) intervention for alcohol use. METHODS: Thirty-five adults with SMI and alcohol dependence participated in a randomized trial of CM for alcohol use, where they were rewarded with prizes contingent on abstinence from alcohol. All participants were interviewed regarding their participation in CM with a consistent structure that included nine open-ended questions. Favored and disliked aspects of CM, perception of alcohol biomarker accuracy, and interest in participating in similar CM interventions provided by treatment centers, rather than researchers, were explored. RESULTS: Participants spoke enthusiastically about receiving prizes, as well as how CM increased their awareness of drinking and helped support their abstinence from alcohol. Most participants felt the ethyl glucuronide biomarker urine tests used to measure alcohol use were accurate, and they were interested in enrolling in CM if it was offered as a clinical program. Research staff who implemented the intervention were well regarded by participants, and interactions with research staff were perceived positively. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: Adults with SMI and alcohol dependence participating in a trial of CM for alcohol use reported overall positive perceptions of and experiences with CM. Receiving small tangible prizes and having positive interpersonal interactions with study staff were reported as especially impactful. These findings indicate that CM is well received by consumers, in addition to its empirical and practical benefits as an evidence-based, low-cost intervention. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Subject(s)
Alcoholism/rehabilitation , Behavior Therapy/methods , Community Mental Health Services/methods , Mental Disorders/rehabilitation , Patient Acceptance of Health Care/psychology , Psychiatric Rehabilitation/methods , Reward , Substance Abuse Detection/psychology , Adult , Alcoholism/urine , Female , Glucuronates/urine , Humans , Male , Middle Aged
6.
Psychiatry Res ; 269: 75-78, 2018 11.
Article in English | MEDLINE | ID: mdl-30145305

ABSTRACT

People generally participate in research for three primary reasons: financial, altruistic/social, and personal/psychological. While we would expect individuals with serious mental illness (SMI) to share these reasons, this assumption has not been investigated. Ninety-two adults with SMI living in supportive housing were interviewed about their reasons for participating in a study examining their housing, well-being, and community experiences. Associations between participant characteristics and reasons for research participation were explored. Primary reasons for participation included "contributing to science/research" (37%, n = 34), "money" (33%, n = 30), "improving housing" (22%, n = 20), "having someone to talk to (2%, n = 2) and other (6%, n = 6). Secondary reasons were "money" (38%, n = 31), "contributing to science/research" (24%, n = 20), "improving housing" (24%, n = 20), "having someone to talk to" (2%, n = 2) and other (11%, n = 9). Additionally, 29% (n = 27) reported making housing or well-being changes since participating. Individual characteristics were not significantly associated with reasons for research participation. Participants' reasons for research participation mirrored the general population, with "improving housing" being a unique motivating factor. Participation in survey research could benefit people with SMI by prompting community engagement and consideration of housing issues.


Subject(s)
Biomedical Research/trends , Housing/trends , Mental Disorders/psychology , Mental Disorders/therapy , Patient Participation/psychology , Patient Participation/trends , Adult , Cross-Sectional Studies , Female , Humans , Male , Middle Aged
7.
Int J Ment Health Addict ; 16(3): 672-679, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29973859

ABSTRACT

The objective of this study was to determine whether the interaction between type of serious mental illness (SMI) and pre-treatment drinking severity, assessed by ethyl glucuronide (EtG), predicts EtG-positive urine samples submitted during treatment in outpatients with co-occurring alcohol dependence and SMI. Seventy-nine participants were randomized to treatment-as-usual or treatment-as-usual and contingency management (CM) targeting alcohol abstinence. Generalized estimating equations were used to assess the interaction of pre-treatment drinking (heavy drinking or light drinking) and SMI diagnosis (major depression, bipolar, or schizophrenia-spectrum disorders) across a 12-week treatment period. In the overall sample, the interaction of drinking severity and SMI diagnosis (p = 0.006) was associated with alcohol abstinence. Exploratory analyses of the interaction term among participants randomized to CM (n = 40; p = 0.008) were associated with alcohol abstinence during CM. Type of SMI diagnosis was associated with treatment outcomes in individuals who engaged in heavy drinking, but not light drinking, prior to treatment.

8.
J Subst Abuse Treat ; 90: 57-63, 2018 07.
Article in English | MEDLINE | ID: mdl-29866384

ABSTRACT

INTRODUCTION: Many American Indian and Alaska Native (AI/AN) people seek evidence-based, cost-effective, and culturally acceptable solutions for treating alcohol use disorders. Contingency management (CM) is a feasible, low-cost approach to treating alcohol use disorders that uses "reinforcers" to promote and support alcohol abstinence. CM has not been evaluated among AI/AN communities. This study explored the cultural acceptability of CM and adapted it for use in diverse AI/AN communities. METHODS: We conducted a total of nine focus groups in three AI/AN communities: a rural reservation, an urban health clinic, and a large Alaska Native healthcare system. Respondents included adults in recovery, adults with current drinking problems, service providers, and other interested community members (n = 61). Focus group questions centered on the cultural appropriateness of "reinforcers" used to incentivize abstinence and the cultural acceptability of the intervention. Focus groups were audio-recorded, transcribed, and coded independently by two study team members using both a priori and emergent codes. We then analyzed coded data. RESULTS: Across all three locations, focus group participants described the importance of providing both culturally specific (e.g., bead work and cultural art work supplies), as well as practical (e.g., gas cards and bus passes) reinforcers. Focus group participants underscored the importance of providing reinforcers for the children and family of intervention participants to assist with reengaging with family and rebuilding trust that may have been damaged during alcohol use. Respondents indicated that they believed CM was in alignment with AI/AN cultural values. There was consensus that Elders or a well-respected community member implementing this intervention would enhance participation. Focus group participants emphasized use of the local AI/AN language, in addition to the inclusion of appropriate cultural symbols and imagery in the delivery of the intervention. CONCLUSIONS: A CM intervention for alcohol use disorders should be in alignment with existing cultural and community practices such as alcohol abstinence, is more likely to be successful when Elders and community leaders are champions of the intervention, the intervention is compatible with counseling or treatment methodologies, and the intervention provides rewards that are both culturally specific and practical.


Subject(s)
/psychology , Alcoholism/therapy , Behavior Therapy/methods , Indians, North American/psychology , Adult , Alcohol Abstinence , Culturally Competent Care , Focus Groups , Humans , Reward , Rural Population , Urban Population
9.
Behav Pharmacol ; 29(5): 462-468, 2018 08.
Article in English | MEDLINE | ID: mdl-29561290

ABSTRACT

Contingency management (CM) is associated with decreases in off-target drug and alcohol use during primary target treatment. The primary hypothesis for this trial was that targeting alcohol use or tobacco smoking would yield increased abstinence in the opposite, nontargeted drug. We used a 2 [CM vs. noncontingent control (NC) for alcohol]×2 (CM vs. NC for smoking tobacco) factorial design, with alcohol intake (through urinary ethyl glucuronide) and tobacco smoking (through urinary cotinine) as the primary outcomes. Thirty-four heavy-drinking smokers were randomized into one of four groups, wherein they received CM, or equivalent NC reinforcement, for alcohol abstinence, smoking abstinence, both drugs, or neither drug. The CM for alcohol and tobacco group had only two participants and therefore was not included in analysis. Compared with the NC for alcohol and tobacco smoking group, both the CM for the tobacco smoking group [odds ratio (OR)=12.03; 95% confidence interval (CI): 1.50-96.31] and the CM for the alcohol group (OR=37.55; 95% CI: 4.86-290.17) submitted significantly more tobacco-abstinent urinalyses. Similarly, compared with the NC for the alcohol and tobacco group, both the CM for smoking (OR=2.57; 95% CI: 1.00-6.60) and the CM for alcohol groups (OR=3.96; 95% CI: 1.47-10.62) submitted significantly more alcohol-abstinent urinalyses. These data indicate cross-over effects of CM on indirect treatment targets. Although this is a pilot investigation, it could help to inform the design of novel treatments for alcohol and tobacco co-addiction.


Subject(s)
Alcohol Abstinence/psychology , Smoking Cessation/methods , Smoking Cessation/psychology , Adult , Alcohol-Related Disorders/physiopathology , Alcoholism/physiopathology , Behavior, Addictive/physiopathology , Behavior, Addictive/psychology , Ethanol/adverse effects , Female , Humans , Male , Middle Aged , Pilot Projects , Smoking/physiopathology , Nicotiana/adverse effects , Tobacco Use Disorder/physiopathology
10.
Subst Abus ; 39(3): 271-274, 2018.
Article in English | MEDLINE | ID: mdl-29161228

ABSTRACT

BACKGROUND: Adults experiencing homelessness and serious mental illnesses (SMI) are at an increased risk of poor mental health and treatment outcomes compared with stably housed adults with SMI. The additional issue of alcohol misuse further complicates the difficulties of those living with homelessness and SMI. In this secondary data analysis, the authors investigated the impact of homelessness on attrition and alcohol use in a contingency management (CM) intervention that rewarded alcohol abstinence in outpatients with SMI. METHODS: The associations between housing status and attrition and alcohol abstinence during treatment, as assessed by ethyl glucuronide (EtG) urine tests, were evaluated in 79 adults diagnosed with alcohol dependence and SMI. RESULTS: Thirty-nine percent (n = 31) of participants reported being homeless at baseline. Individuals who were homeless were more likely to drop out of CM (n = 10, 62.5%) than those who were housed (n = 4, 16.7%), χ2(1) = 8.86, P < .05. Homelessness was not associated with attrition in the noncontingent control group. Accounting for treatment group and prerandomization EtG levels, neither the effect of housing status nor the interaction of housing status and group were associated with EtG-assessed alcohol abstinence during treatment. CONCLUSIONS: Individuals experiencing homelessness and co-occurring alcohol dependence and SMI receiving CM had higher rates of attrition, relative to those who were housed. Homelessness was not associated with differences in biologically assessed alcohol abstinence.


Subject(s)
Alcohol Abstinence/psychology , Alcoholism/epidemiology , Ill-Housed Persons/psychology , Mental Disorders/epidemiology , Outpatients/psychology , Patient Compliance/psychology , Adult , Alcoholism/therapy , Alcoholism/urine , Behavior Therapy , Comorbidity , Female , Glucuronates/urine , Humans , Male , Middle Aged , Washington/epidemiology
11.
Psychiatry Res ; 260: 233-235, 2018 02.
Article in English | MEDLINE | ID: mdl-29220679

ABSTRACT

We examined whether the interaction of baseline stimulant use, assessed by urine drug tests, and type of serious mental illness (SMI) diagnosis predicted stimulant use in a trial of contingency management (CM). The interaction between baseline stimulant use and SMI diagnoses was significant in the overall sample (p=0.002) when controlling for the main effects of treatment condition, baseline stimulant use, and SMI diagnosis. Similar results were also found within the CM sample. Individuals with bipolar disorder were more or less likely, depending on their baseline stimulant-drug test results, to use stimulants during treatment compared to those with other SMI diagnoses.


Subject(s)
Behavior Therapy/methods , Bipolar Disorder/therapy , Central Nervous System Stimulants , Depressive Disorder, Major/therapy , Outcome Assessment, Health Care , Schizophrenia/therapy , Substance-Related Disorders/therapy , Adult , Bipolar Disorder/epidemiology , Central Nervous System Stimulants/urine , Comorbidity , Depressive Disorder, Major/epidemiology , Female , Humans , Male , Middle Aged , Schizophrenia/epidemiology , Substance-Related Disorders/epidemiology
12.
Behav Pharmacol ; 29(4): 370-374, 2018 06.
Article in English | MEDLINE | ID: mdl-29035917

ABSTRACT

Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Rates of smoking-negative breath samples (carbon monoxide <3 ppm) were compared between the two groups while controlling for baseline carbon monoxide level, marijuana use, MA use, and time. This subgroup of mostly male (59%) participants included 44 participants in the CM group and 17 participants in the standard psychosocial treatment. Tobacco smoking participants who received CM targeting MA use were 140% (odds ratio: 2.395; 95% confidence interval: 1.073-5.346) more likely to submit a smoking-negative breath sample relative to standard psychosocial treatment during the treatment period, holding constant several other prespecified covariates. This study provides evidence that a behavioral treatment for MA use results in reductions in cigarette smoking in adults with MA-use disorder.


Subject(s)
Cigarette Smoking/psychology , Smoking Cessation/methods , Substance-Related Disorders/psychology , Adult , Behavior Therapy/methods , Cigarette Smoking/metabolism , Cigarette Smoking/therapy , Female , Humans , Male , Methamphetamine/adverse effects , Middle Aged , Preliminary Data , Smoking/psychology , Substance-Related Disorders/physiopathology , Tobacco Smoking , Tobacco Use Disorder
13.
Sex Res Social Policy ; 14(3): 270-274, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28979572

ABSTRACT

Limited research has investigated the perceived influence of sexually explicit online media (SEOM) on body satisfaction and partner expectations of men who have sex with men (MSM). Semi-structured qualitative interviews were conducted with 16 MSM, covering the perceived influence of MSM-specific SEOM. All nine men who broached the topics of body satisfaction and partner expectations reported that MSM-specific SEOM set unreasonably high physical appearance expectations for themselves and/or their potential partners. Although MSM-specific SEOM might be negatively affecting body satisfaction and partner expectations among MSM, its ubiquity may make it a useful tool to support body positivity.

14.
Cannabis Cannabinoid Res ; 2(1): 133-138, 2017.
Article in English | MEDLINE | ID: mdl-28861513

ABSTRACT

Introduction: People with serious mental illness (SMI) use cannabis more than any other illicit drug. Cannabis use is associated with increased psychotic symptoms and is highly comorbid with alcohol use disorders (AUDs). Despite the national trend toward decriminalization, little is known about the prevalence, correlates, and impact of cannabis use on those with SMI receiving treatment for substance use disorders, a group at high risk for the negative effects of cannabis use. Methods: In this secondary data analysis, cannabis use prevalence, correlates, and impact on treatment outcomes were examined in 121 adults with cooccurring SMI and AUDs receiving outpatient addiction treatment in a randomized trial of contingency management (CM) for alcohol. Prevalence and frequency of cannabis use were calculated across the 7-month study period using self-report and urine tests. Cannabis users were compared with nonusers by SMI diagnosis, psychiatric symptoms, medical problems, legal problems, and HIV-risk behavior. The relationship between cannabis use and longest duration of alcohol abstinence in participants randomized to CM (n=40) was assessed. Results: Fifty-seven (47%) of participants submitted at least one cannabis-positive urine sample during the study. Out of the 2834 total samples submitted, 751 (27%) were positive for cannabis. Cannabis users were 2.2 times more likely to submit an alcohol-positive sample, and 2.5 times more likely to submit a cocaine-positive sample at baseline, relative to noncannabis users (p=0.01). Cannabis users were more likely to engage in risky sexual behavior (p=0.01) and to report being homeless (p=0.03) than nonusers. When controlling for pretreatment alcohol use, the relationship between comorbid cannabis use and alcohol abstinence during CM was not significant (p=0.77). Conclusion: Rates of comorbid cannabis use were high in this sample of adults with SMI and AUDs. Cannabis use was correlated with recent alcohol and cocaine use, risky sexual behavior, and homelessness, but not with alcohol abstinence during CM.

15.
Am J Addict ; 26(7): 673-675, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28833832

ABSTRACT

BACKGROUND AND OBJECTIVES: This study investigated if pretreatment ethyl glucuronide (EtG) levels corresponding to light (100 ng/mL), heavy (500 ng/mL), and very heavy (1,000 ng/mL) drinking predicted longest duration of alcohol abstinence (LDA) and proportion of EtG-negative urine tests in outpatients receiving a 12-week EtG-based contingency management (CM) intervention for alcohol dependence. METHODS: Participants were 40 adults diagnosed with alcohol use disorders and serious mental illness who submitted up to 12 urine samples for EtG analysis during a 4-week observation period and were then randomized to 12-weeks of CM for alcohol abstinence and addiction treatment attendance. Alcohol use outcomes during CM as assessed by EtG and self-report were compared across those who did and did not attain a pre-treatment average EtG level of 500 ng/mL-a level that equates to frequent heavy drinking. RESULTS: Only the 500 ng/mL cutoff was associated with significant differences in LDA and proportion of EtG-negative samples during CM. Those with a pre-treatment EtG < 500 ng/mL attained a LDA 2.3 (alcohol) to 2.9 (drugs) weeks longer than pre-treatment heavy drinkers. DISCUSSION AND CONCLUSIONS: The EtG biomarker can be used to determine who will respond to a CM intervention for alcohol use disorders and could inform future trials that are designed to be tailored to individual patients. SCIENTIFIC SIGNIFICANCE: Results suggest pre-treatment EtG cutoffs equivalent to heavy and very heavy drinking predict outcomes in CM. (Am J Addict 2017;26:673-675).


Subject(s)
Alcoholism/therapy , Behavior Therapy/methods , Glucuronates , Mental Disorders , Adult , Alcoholism/complications , Alcoholism/diagnosis , Alcoholism/urine , Biomarkers/analysis , Biomarkers/urine , Diagnosis, Dual (Psychiatry) , Diagnostic and Statistical Manual of Mental Disorders , Female , Glucuronates/analysis , Glucuronates/urine , Humans , Male , Mental Disorders/complications , Mental Disorders/diagnosis , Middle Aged , Outpatients , Predictive Value of Tests , Self Report , Treatment Outcome
16.
Psychol Addict Behav ; 31(5): 608-613, 2017 08.
Article in English | MEDLINE | ID: mdl-28714726

ABSTRACT

Phosphatidylethanol (PEth) can be detected in blood from 14 to as many as 28 days after alcohol consumption, depending on the amount and frequency of alcohol consumed. PEth may have utility for verifying abstinence in a contingency management (CM) intervention for alcohol use, particularly in settings where frequent verification of abstinence is impossible or impractical. Five nontreatment-seeking heavy drinkers (40% men) participated in an 11-week, ABA-phased within-subject experiment for which they submitted blood spots for PEth measurement, urine samples for ethyl glucuronide (EtG) testing, and self-report drinking data weekly. Participants received reinforcers for submitting samples throughout the A phases. During the B phase (CM phase), they received additional reinforcers when their PEth level was reduced from the previous week and was verified by a negative EtG (<150 ng/ml) urine test and self-report. PEth, EtG, and self-report outcomes were compared between A phases (Weeks 1-3, 8-11) and B phases (Weeks 4-7). During the A phases, 23% of PEth results indicated alcohol abstinence, whereas 53% of PEth samples submitted during the CM (B phase) indicated alcohol abstinence. Participants were more likely to submit EtG-negative urine samples and report lower levels of drinking and heavy drinking during the B phase, relative to the A phases. We also explored the ability of PEth to detect self-reported drinking. The combined PEth homologs (16:0/18:1 and 16:0/18:2) predicted self-reported drinking with area under the curve from 0.81 (1 week) to 0.80 (3 weeks). Results support the initial feasibility of a Peth-based CM intervention. (PsycINFO Database Record


Subject(s)
Alcohol Abstinence , Alcohol Drinking/metabolism , Glucuronates/urine , Glycerophospholipids/blood , Adult , Alcohol Drinking/blood , Alcohol Drinking/urine , Behavior Therapy , Female , Humans , Male , Middle Aged , Pilot Projects , Self Report
18.
Am J Psychiatry ; 174(4): 370-377, 2017 Apr 01.
Article in English | MEDLINE | ID: mdl-28135843

ABSTRACT

OBJECTIVE: The authors examined whether a contingency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious mental illnesses. Secondary objectives were to determine whether contingency management was associated with changes in heavy drinking, treatment attendance, drug use, cigarette smoking, psychiatric symptoms, and HIV-risk behavior. METHOD: Seventy-nine (37% female, 44% nonwhite) outpatients with serious mental illness and alcohol dependence receiving treatment as usual completed a 4-week observation period and were randomly assigned to 12 weeks of contingency management for EtG-negative urine samples and addiction treatment attendance, or reinforcement only for study participation. Contingency management included the variable magnitude of reinforcement "prize draw" procedure contingent on EtG-negative samples (<150 ng/mL) three times a week and weekly gift cards for outpatient treatment attendance. Urine EtG, drug test, and self-report outcomes were assessed during the 12-week intervention and 3-month follow-up periods. RESULTS: Contingency management participants were 3.1 times (95% CI=2.2-4.5) more likely to submit an EtG-negative urine test during the 12-week intervention period, attaining nearly 1.5 weeks of additional alcohol abstinence compared with controls. Contingency management participants had significantly lower mean EtG levels, reported less drinking and fewer heavy drinking episodes, and were more likely to submit stimulant-negative urine and smoking-negative breath samples, compared with controls. Differences in self-reported alcohol use were maintained at the 3-month follow-up. CONCLUSIONS: This is the first randomized trial utilizing an accurate and validated biomarker (EtG) to demonstrate the efficacy of contingency management for alcohol dependence in outpatients with serious mental illness.


Subject(s)
Alcoholism/therapy , Alcoholism/urine , Glucuronates/urine , Mental Disorders/blood , Mental Disorders/therapy , Token Economy , Adult , Alcoholism/epidemiology , Alcoholism/psychology , Ambulatory Care , Comorbidity , Diagnosis, Dual (Psychiatry) , Female , Follow-Up Studies , Humans , Male , Mental Disorders/epidemiology , Mental Disorders/psychology , Middle Aged , Patient Compliance/psychology
19.
Contemp Clin Trials ; 47: 93-100, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26706667

ABSTRACT

BACKGROUND: Disproportionately high rates of alcohol use disorders are present in many American Indian/Alaska Native (AI/AN) communities, yet little information exists regarding the effectiveness of alcohol treatments in AI/AN populations. Contingency management is an intervention for illicit drug use in which tangible reinforcers (rewards) are provided when patients demonstrate abstinence as assessed by urine drug tests. Contingency management has not been widely studied as an intervention for alcohol problems because until recently, no alcohol biomarker has been available to adequately verify abstinence. AIMS: The HONOR Study is designed to determine whether a culturally-tailored contingency management intervention is an effective intervention for AI/AN adults who suffer from alcohol use disorders. METHODS: Participants include 400 AI/AN alcohol-dependent adults residing in one rural reservation, one urban community, as well as a third site to be decided, in the Western U.S. Participants complete a 4-week lead-in phase prior to randomization, then 12 weeks of either a contingency management intervention for alcohol abstinence, or a control condition where participants receive reinforcers for attending study visits regardless of alcohol use. Participants are then followed for 3-more months post-intervention. The primary study outcome is urinary ethyl glucuronide-confirmed alcohol abstinence; secondary outcomes include self-reported alcohol and drug use, HIV risk behaviors, and self-reported cigarette smoking. DISCUSSION: This will be the largest randomized, controlled trial of any alcohol for AI/ANs and the largest contingency management study targeting alcohol use disorders, thus providing important information to AI/AN communities and the alcohol treatment field in general.


Subject(s)
Alcoholism/therapy , Behavior Therapy/methods , Culturally Competent Care/methods , Indians, North American , Reward , Alcoholism/ethnology , Alcoholism/urine , Focus Groups , Glucuronates/urine , HIV Infections , Humans , Qualitative Research , Risk-Taking , Smoking , Substance-Related Disorders , United States
20.
Drug Alcohol Depend ; 157: 184-7, 2015 Dec 01.
Article in English | MEDLINE | ID: mdl-26475403

ABSTRACT

AIMS: This study investigated which ethyl glucuronide immunoassay (EtG-I) cutoff best detects heavy versus light drinking over five days in alcohol dependent outpatients. METHODS: A total of 121 adults with alcohol use disorders and co-occurring psychiatric disorders took part in an alcohol treatment study. Participants provided self-reported drinking data and urine samples three times per week for 16-weeks (total samples=2761). Agreement between low (100 ng/mL, 200 ng/mL), and moderate (500 ng/mL) EtG-I cutoffs and light (women ≤3 standard drinks, men ≤4 standard drinks) and heavy drinking (women >3, men >4 standard drinks) were calculated over one to five days. RESULTS: The 100 ng/mL cutoff detected >76% of light drinking for two days, and 66% at five days. The 100 ng/mL cutoff detected 84% (1 day) to 79% (5 days) of heavy drinking. The 200 ng/mL cutoff detected >55% of light drinking across five days and >66% of heavy drinking across five days. A 500 ng/mL cutoff identified 68% of light drinking and 78% of heavy drinking for one day, with detection of light (2-5 days <58%) and heavy drinking (2-5 days <71%) decreasing thereafter. Relative to 100 ng/mL, the 200 ng/mL and 500 ng/mL cutoffs were less likely to result in false positives. CONCLUSIONS: An EtG-I cutoff of 100 ng/mL is most likely to detect heavy drinking for up to five days and any drinking during the previous two days. Cutoffs of ≥500 ng/mL are likely to only detect heavy drinking during the previous day.


Subject(s)
Alcohol Drinking/urine , Alcoholism/urine , Glucuronates/urine , Substance Abuse Detection/methods , Adult , Alcoholism/diagnosis , Biomarkers/urine , Female , Humans , Immunoassay/methods , Immunoassay/standards , Male , Middle Aged , Outpatients , Reference Standards , Self Report , Spectrophotometry
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