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1.
Leuk Res ; 59: 12-19, 2017 08.
Article in English | MEDLINE | ID: mdl-28535394

ABSTRACT

Alloimmunization to Red Blood Cell (RBC) antigens frequently occurs in patients with myeloid neoplasms (AML, MDS and CMML) and potentially poses the patient at risk for delayed hemolytic transfusion reactions and limited supply of compatible RBC-units. However, there is comparatively little data on transfusion associated characteristics in this patient cohort. We therefore retrospectively analyzed transfusion requirements and clinical outcomes of 184 patients with myloid neoplasms treated with azacitidine at the Paracelsus Medical University Salzburg, which were included in the Austrian Registry of Hypomethylating Agents. The mean blood component requirements for AML, MDS and CMML were 39.8, 67.4 and 31.4 RBC units and 31.7, 27.6 and 19.1 platelet (PLT) units respectively. In spite of an extended and stringent RBC unit matching policy (ABO, RhD, RhCcEe and K antigens), 20 (11%) patients formed at least one alloantibody ("allo-group"), whereas 164 patients (89%) did not ("non-allo-group"). The most frequent antibody specificity was anti-E, followed by anti-Wra -Lua, -D, -C and -Jka. Alloimmunization was associated with higher numbers of transfused RBC units (68 vs. 38; p=0.001), as well as with longer time under transfusion (16.7 vs. 9.4 months; p=0.014). Median overall survival (OS) did not differ significantly between the "allo"- and "non-allo-group".


Subject(s)
Erythrocytes/immunology , Myelodysplastic Syndromes/therapy , Adult , Aged , Antimetabolites, Antineoplastic/therapeutic use , Azacitidine/therapeutic use , Erythrocyte Transfusion/adverse effects , Erythrocyte Transfusion/methods , Female , Humans , Isoantibodies/blood , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/mortality , Leukemia, Myeloid, Acute/therapy , Male , Middle Aged , Myelodysplastic Syndromes/complications , Myelodysplastic Syndromes/mortality , Retrospective Studies , Survival Rate , Transfusion Reaction/etiology
2.
Ultramicroscopy ; 109(5): 563-7, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19167824

ABSTRACT

The surface morphology of grades 304L and 316LN stainless steels, after low-temperature bake-out process and vacuum annealing, has been studied by atomic force microscopy (AFM) and scanning tunnelling microscopy (STM). The local elemental composition on the surface before and after thermal treatment has been investigated by atom probe (AP) depth profiling measurements. After vacuum annealing, AFM and STM show significant changes in the surface structure and topology. Recrystallization and surface reconstruction is less pronounced on the 316LN stainless steel. AP depth profiling analyses result in noticeable nickel enrichment on the surface of grade 304L samples. Since hydrogen recombination is almost controlled by surface structure and composition, a strong influence on the outgassing behaviour by the particular surface microstructure can be deduced.

3.
Ultramicroscopy ; 95(1-4): 189-97, 2003.
Article in English | MEDLINE | ID: mdl-12535564

ABSTRACT

Processes occurring at the interface of two materials coming in contact, separating or moving with respect to each other have been studied with the scanning tunnelling microscope (STM) and atom-probe (AP) field ion microscopy (APFIM). STM probe tips have been first characterised by field ion microscopy (FIM), brought into well-defined contact in the STM and afterwards inspected by time-of-flight AP. The results from mechanical contact and indentation experiments, showing material transfer and neck formation, are in reasonable good agreement with computer-based simulations on metal tip-surface interactions.

4.
Anal Bioanal Chem ; 353(3-4): 251-3, 1995 Oct.
Article in English | MEDLINE | ID: mdl-15048476

ABSTRACT

Three dimensional atom-probe measurements have been carried out to study the segregation behaviour of Mo(x)W((1-x)) alloys (x = 0.9; 0.75; 0.5; 0.25). As predicted from alloy thermodynamics, on in situ annealed specimens a significant surface enrichment of molybdenum has been observed. For alloys with tungsten contents above 25% the composition profiles measured are in a good agreement with the theoretical predictions. The positive regular solution parameter of this binary system gives reason for a random distribution of alloy components. In the three-dimensional reconstructions local agglomerations and combined features of tungsten atoms are to observe in alloys with Mo as major component.

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