A drainage network-based impact matrix to support targeted blue-green-grey stormwater management solutions.

Urban floods will continue to be an alarming issue worldwide due to climate change and urban expansion. The costly and less environmentally friendly grey infrastructure is not always the most adequate solution to resolve urban pluvial flooding issues. The combination of grey and blue-green infrastructures, also called hybrid infrastructure, has been considered a promising solution for urban stormwater management. Existing approaches for identifying suitable hybrid solutions frequently rely on global multi-objective optimization algorithms. We developed a pre-screening method that decomposes a drainage network into clusters of pipes connected to sub-catchments, based on pipe hydraulic characteristic that allows for the impact of infrastructure combinations (blue-green and grey) to be mapped. Four impact matrices are proposed to map the total, local, upstream, and downstream flood reduction of all possible blue-green, grey, and hybrid solutions. Using an urban catchment in Guangzhou (China) as a case study, results showed that such an exercise could identify prime candidate locations for blue-green and grey infrastructure while filtering out ineffective locations for flood reduction. Furthermore, the impact matrices enabled the identification of flood zones where blue-green infrastructure could handle flood mitigation without the need of local grey infrastructure upgrades. As such, they are not only useful for quick screening of suitable interventions for each flooded zone, but can also potentially serve as a priori knowledge before diving into the data and computationally expensive process of finding the most effective flood mitigation solutions.

Comparative analysis of temporal trends of obesity and physical inactivity in Brazil and the USA (2011-2021).

BACKGROUND: The prevalence of obesity is rising in all subregions of America, including Brazil. To understand the obesity problem in Brazil better, a possible approach could be to analyze its obesity trend by comparing it with the reality of a country that went previously through the epidemiological transition, such as the USA. In addition, the obesity trend must be analyzed in comparison with obesity risk factors trends, such as the physical inactivity (PI) trend. Our aim was comparatively to analyze the temporal trends of obesity between Brazil and the USA from the perspective of temporal trends of PI. METHODS: We conducted a temporal trend study based on data from national cross-sectional surveys: the VIGITEL (Surveillance System for Factors of Health Risk and Protection for Chronic Diseases by Telephone Survey) for Brazil and the BRFSS (Behavioral Risk Factor Surveillance System) for the USA, comparing the annual prevalence of obesity and PI between 2011 and 2021. For the analysis of each temporal variation, linear regressions were performed with the Prais-Winsten test, and Pearson's correlation coefficient was conducted to correlate the trends of the same variables between countries and of different variables within each country. RESULTS: Considering the total sample, Brazil [coefficient (95%CI) 0.6 (0.4;0.7), p = 0.000] and the USA [coefficient (95%CI) 0.5 (0.5;0.6), p = 0.000] showed increasing trends in obesity. The tendency of PI was of stabilization in the two countries [Brazil: coefficient (95%CI) -0.03 (-0.3;0.2), p = 0.767 and USA coefficient (95%CI) -0.03 (-0.2;0.1), p = 0.584]. In addition, there was a correlation between obesity trends between Brazil and the USA (r = 0.971; p = 0.000), but there was no correlation between PI trends between the two countries, nor with obesity and PI trends within each country. CONCLUSIONS: In the last decade, there was a trend towards increasing obesity and stabilization in PI, both in Brazil and the USA. However, there was no association between temporal trends in obesity and physical inactivity in both countries. Our data reinforce a call to action to prevent and control obesity, going with and beyond PI reduction.

The influence of middle-aged male driver profile on driving performance and the effects of three perceptual countermeasures: A simulator study.

The human-environment-vehicle triad and how it relates to crashes has long been a topic of discussion, in which the human factor is consistently seen as the leading cause. Recently, more sophisticated approaches to Road Safety have advocated for a road-driver interaction view, in which human characteristics influence road perception and road environment affects driver behavior. This study focuses on road-driver interaction by using a driving simulator. The objective is to investigate how the driver profile influences driving performance and the effects of three countermeasures (peripheral transverse lines before and after the beginning of the curves and roadside poles in the curves). Fifty-six middle-aged male participants drove a non-challenging rural highway simulated scenario based on a real road where many single-vehicle crashes occurred. The drivers' profiles were assessed through their behavioral history measured by a validated version of the Driver Behavior Questionnaire (DBQ) comprising three dimensions: Errors (E), Ordinary Violations (OV), and Aggressive Violations (AV). The relationship between speed and trajectory measures and drivers' profiles was investigated using random-parameter models with heterogeneity in the means. The models' results showed that the DBQ subscale scores in OV explained a considerable part of the heterogeneity found in drivers' performance. Furthermore, the heterogeneity in the means caused by the DBQ subscale scores in OV and E in the presence of peripheral transverse lines indicates a difference in how drivers react to the countermeasures. The peripheral lines were more efficient than roadside poles to moderate speed but did not positively influence all drivers' trajectories. Although the peripheral lines could be seen as an alternative to change driver behavior in a non-challenging or monotonous road environment, the design used in this study should be reviewed.

The fate of spinal arteries after the stent-assisted balloon-induced intimal disruption and relamination in aortic dissection repair technique: a case series.

Objective: We evaluated the patency of the spinal arteries (intercostal and lumbar) after the STABILISE (stent-assisted balloon-induced intimal disruption and relamination in aortic dissection repair) technique. Methods: A retrospective analysis of all patients with aortic dissection treated with the STABILISE technique between April 2018 and July 2021 was performed. Imaging analysis of the spinal cord vascular supply was accomplished using multiplanar and maximum intensity projection reconstructed images of pre- and postoperative computed tomography angiograms at 1 month, 12 months, and annually thereafter. Results: Twelve patients were treated for complicated aortic dissection. Primary technical success was 100% and mid-term clinical success, at a mean follow-up of 27 ± 12 months, was 90%. No cases of spinal cord ischemia were identified. One patient died after 1 year (non-aortic related), and one patient was lost to follow-up. A significant decrease was found in the mean number of patent spinal arteries in the stent graft area at 1 month (P < .001), 1 year (P < .001), and 2 years (P = .004). However, no significant reduction was found in the number of spinal arteries in either the bare metal stented or nonstented aorta (P > .05). Conclusions: Use of the STABILISE technique decreased intercostal artery patency in the thoracic stent graft area, but spinal artery patency was not significantly affected by the bare metal stent nor its aggressive ballooning. These findings constitute a step toward a better understanding of the safety of this technique.

Proposing a holistic research framework for university strategic alliances in sustainable entrepreneurship.

This study presents a systematic literature review aimed at mapping the main areas of study on the relationship between higher education institutions' strategic alliances and sustainable entrepreneurship. To that end, it carried out three complementary analyses: topic mapping, co-citation, and overlay visualization, in order to provide a comprehensive picture of that relationship from 1994 to 2022. The empirical approach is based on a total sample of 207 articles published in the Web of Science database, which was screened in terms of title, abstract and keywords, and subject to a search protocol involving inclusion and exclusion criteria. Using VOSviewer software, a three-pronged approach is used to identify five topic clusters: (1) The impact of entrepreneurship on community sustainability and social innovation; (2) Strategic alliances for sustainable development, innovation, and performance; (3) Value creation through social entrepreneurship partnerships; (4) Challenges for knowledge-based sustainable cities; and (5) Collaboration between businesses and social enterprises; revealing the role of knowledge, co-creation, sustainable entrepreneurship, and social innovation as levers of sustainable development. As a result of this systematic literature review, a holistic research framework is proposed, positioning sustainable entrepreneurship as a priority target for strategic alliances in higher education institutions, with reference to the experience of implementing the European University concept. This framework helps to position joint cooperation and strategic alliances among the major stakeholders in knowledge-based economies, which frequently leads to knowledge-based development based on sustainable entrepreneurship.

Use of Checkpoint Inhibitors in Gray Zone Lymphoma.

Checkpoint inhibitors, cancer immunotherapies, are the new forms of treatment for gray zone lymphoma, a rare subtype that combines the characteristics of both Hodgkin and non-Hodgkin disease forms. Programmed cell death protein 1/programmed cell death ligand 1 (PD-L1/PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) modulate the immune system function. Immunological checkpoints can be stimulatory or inhibitory, and tumors can use these checkpoints to protect against immune system attacks. This is a case report of a difficult diagnosis and describes the most current treatment using checkpoint inhibitors, through the review of the clinical record of a patient diagnosed with gray area lymphoma in August 2019, using a descriptive and cross-sectional analysis of the clinical history and disease evolution. The case showed that pembrolizumab therapy is an effective treatment option for patients with rare gray zone lymphoma refractory to different lines of treatment. Both the diagnosis and treatment of gray area lymphoma remain a challenge for the medical and multiprofessional teams, and collaboration between them ensured effective treatment for the patient.

A framework for modelling in-sewer thermal-hydraulic dynamic anomalies driven by stormwater runoff and seasonal effects.

Rain-induced surface runoff and seasons lead to short- to medium-term anomalies in combined storm- and wastewater flows and temperatures, and influence treatment processes in wastewater resource recovery facilities (WRRF). Additionally, the implementation of decentralized heat recovery (HR) technologies for energy reuse in buildings affect energy-related processes across the urban water cycle and WRRFs heat inflows. However, quantitative insights on thermal-hydraulic dynamics in sewers at network scale and across different scales are very rare. To enhance the understanding of thermal-hydraulic dynamics and the water-energy nexus across the urban water cycle we present a modular framework that couples thermal-hydraulic processes: i) on the surface, ii) in the public sewer network, iii) in households (including in-building HR systems), and iv) in lateral connections. We validate the proposed framework using field measurements at full network scale, present modelling results of extended time periods to illustrate the effect of seasons and precipitation events simultaneously, and quantify the impact of decentralized HR devices on thermal-hydraulics. Simulation results suggest that the presented framework can predict temperature dynamics consistently all year long including short- to long-term variability of in-sewer temperature. The study provides quantitative evidence that the impact of household HR technologies on WRRF inflow heat budgets is reduced by approximately 20% during wet-weather periods in comparison to dry-weather conditions. The presented framework has potential to support multiple research initiatives that will improve the understanding of the water-energy nexus, pollutant dispersion and degradation, and support maintenance campaigns at network scale.

Erdheim-Chester disease: Typical radiologic findings of a multisystemic disease.

Erdheim-Chester disease is a rare and multisystemic entity. It results from the infiltration of tissues by foamy histiocytes. The etiology is unknown, but there are mutations in the MAPK pathway in over 80% of patients, more frequently BRAF mutation. The most commonly affected organs and systems are the skeleton, central nervous system, cardiovascular system, kidney, lungs, and skin. The most common clinical manifestations are bone pain, usually in the lower limbs, and diabetes insipidus. The diagnosis is challenging. It requires a combination of clinical, radiological, histopathological, and molecular findings. We present the case of a patient with typical clinical and radiological manifestations: bone pain and diabetes insipidus at presentation, bilateral long bone cortical sclerosis, hairy kidney appearance, coated aorta, right atrium pseudotumor, and periorbital masses.

Idiopathic pneumatosis cystoides coli: An uncommon cause of pneumoperitoneum.

Pneumatosis cystoides intestinalis (PCI) is a rare entity characterized by the presence of gaseous cystic within the intestinal wall. The primary or idiopathic type represents 15% of cases and is a self-limited or chronic benign entity. The secondary type represents 85% of cases and is associated with various factors, such as surgery, pharmacotherapy, chemotherapy, autoimmune diseases, inflammatory diseases, and pulmonary illness. Pneumatosis cystoides intestinalis affects the colon (pneumatosis cystoides coli) in about half of the cases. The differential diagnosis of PCI includes potentially life-threatening diseases that cause pneumatosis intestinalis. The misdiagnosis of PCI is common and can lead to unnecessary treatments and surgical procedures. We describe an asymptomatic pneumoperitoneum incidentally seen on chest radiograph. The cause was pneumatosis cystoides coli, which did not require treatment.

Burnout and Quality of Work Life among Municipal Workers: Do Motivating and Economic Factors Play a Mediating Role?

This study analyzes the relationship between burnout and quality of work life among municipal workers subjected to higher levels of stress and emotional exhaustion, impacting their occupational health in the context of the COVID-19 pandemic. With a sample of 459 municipal workers, the relationship between burnout and quality of work life is tested by considering the isolated mediating effect of the feeling of contributing to productivity and the combined effects of two mediators representing the feeling of contributing to productivity and receiving an appropriate salary. The main findings include a negative association between the three dimensions of burnout: emotional exhaustion, feelings of cynicism, and a sense of being less effective, and the mediators: contribution to productivity and appropriate salary. Also detected was an important mediating role associated with the effects of not feeling contributive at work, as well as not being well paid, on the relation between the burnout syndrome dimension of low effectiveness and quality of work life. For future action by public authorities and public managers, the need is highlighted to create innovative human resource management frameworks and flexible work organization, with remuneration plans based on productivity goals and aimed at an improved balance between personal life and work.

Frontiers in Occupational Health and Safety Management.

This Special Issue of the International Journal of Environmental Research and Public Health is devoted to the "Frontiers in Occupational Health and Safety Management" [...].

Catamenial pneumothorax: a rare manifestation of endometriosis.

Endometriosis is a common gynecological disease that primarily affects premenopausal women. It is mainly found in the pelvis but may be found at several extrapelvic locations. Thoracic endometriosis is a rare extrapelvic location of endometriosis and the leading cause of catamenial pneumothorax. We describe the case of a 35-year-old woman with a background of pelvic pain presenting to the emergency department with chest pain and dyspnea. The chest X-ray in the emergency department showed a large right-sided pneumothorax. Further imaging studies during patient evaluation revealed extensive fibrotic changes in the pelvis and well-defined solid nodules with high signal on T2 and T1-weighted images on MRI in abdominal and thoracic locations, rendering the diagnosis of a catamenial pneumothorax in a patient with pelvic, abdominal and thoracic endometriosis.

Modelo Lógico do Programa Tribunal Superior do Trabalho em Movimento: uma construção de 15 anos de experiência / Logic Model of the Tribunal Superior do Trabalho em Movimento Program: a construction of 15 years of experience

Na perspectiva de promover saúde no local de trabalho, com ênfase na atividade física (AF), em 2004 o Tribunal Superior do Trabalho (TST), em Brasília, Distrito Federal, criou o Programa TST em Movimento. O objetivo deste estudo foi descrever o modelo lógico (ML) do Programa, a partir de sua construção histórica. O ML foi desenvolvido seguindo as diretrizes do Centers of Disease Control and Prevention, descrevendo objetivo, recursos, atividades, produtos, metas, fatores influenciadores e público-alvo. Sua construção incluiu a análise de documentos do Programa, como o relatório de resultados de 2019. O Programa é composto por profissionais de educação física, fisioterapia e estagiários, oferecendo atividades como educação em saúde, práticas de AF, eventos e monitoramento de indicadores em saúde. O ML apresentado é fruto de 15 anos de experiência e passa a compor os processos avaliativos e o acompanhamento das metas, iluminando a sustentabilidade do Programa em bases sólidas

From the perspective of promoting health in the workplace, with an emphasis on physical activity (PA), in 2004 the Tribunal Superior do Trabalho (TST), in Brasília, Distrito Federal, created the TST em Mo­vimento Program. The aim of this study was to describe the logical model (LM) of the Program, based on its historical construction. The LM was developed following the Centers of Disease Control and Prevention guidelines, describing objective, resources, activities, products, goals, influencing factors, and target audience. Its construction included the analysis of Program documents, such as the 2019 results report. The Program is composed of physical education professionals, physiotherapy, and trainees, offering activities such as health education, PA practices, events, and monitoring of health indicators. The LM presented is the result of 15 years of experience and becomes part of the evaluation processes and monitoring of goals, illuminating the Program's sustainability on solid foundations

Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature.

INTRODUCTION: Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases of previously healthy young adults diagnosed with a hematologic malignancy after experiencing COVID-19, we raise the hypothesis that the SARS-Cov-2 infection could act as a trigger for leukemogenesis in predisposed individuals. METHODS: This was a case series performed through extraction of relevant clinical information from the medical records of three patients admitted to our Hematology unit between August 2020 and September 2020. MAIN RESULTS: Considering the relatively rapid development of cytopenias following recovery from COVID-19, it cannot be ruled out that SARS-Cov-2 played a role in leukemogenesis in those patients. Based on previous in vitro studies, the renin-angiotensin system imbalance induced by SARS-CoV-2 could potentially promote in vivo leukemogenesis through several mechanisms. CONCLUSION: Despite the advances in pathophysiological and clinical characterization of COVID-19, the consequences of the pandemic to the incidence of hematologic diseases are still to be elucidated. In this context, future dissection of the status of the local bone marrow renin-angiotensin system in leukemogenesis is a clinically relevant basic research area.

Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature

Abstract Introduction Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases of previously healthy young adults diagnosed with a hematologic malignancy after experiencing COVID-19, we raise the hypothesis that the SARS-Cov-2 infection could act as a trigger for leukemogenesis in predisposed individuals. Methods This was a case series performed through extraction of relevant clinical information from the medical records of three patients admitted to our Hematology unit between August 2020 and September 2020. Main Results Considering the relatively rapid development of cytopenias following recovery from COVID-19, it cannot be ruled out that SARS-Cov-2 played a role in leukemogenesis in those patients. Based on previous in vitro studies, the renin-angiotensin system imbalance induced by SARS-CoV-2 could potentially promote in vivo leukemogenesis through several mechanisms. Conclusion Despite the advances in pathophysiological and clinical characterization of COVID-19, the consequences of the pandemic to the incidence of hematologic diseases are still to be elucidated. In this context, future dissection of the status of the local bone marrow renin-angiotensin system in leukemogenesis is a clinically relevant basic research area.

In search of intangible connections: intellectual capital, performance and quality of life in higher education institutions.

This study explores the contributions of different dimensions of the intellectual capital of higher education institutions (ICHEIs) to their performance, incorporating the previously unexplored dimension of quality of life (QoL) as a performance measure, and correspondingly taking into account the connection between the Theory of Stakeholders and the Theory of Legitimacy. Applying a Structural Equation Model and the Partial Least Squares method, we present new empirical findings from a sample of 738 students and 587 lecturers/researchers from seven Portuguese public HEIs. The ICHEIs positively influence the institution's performance, through relational capital and structural capital; and QoL emerges as an important dimension of HEIs' performance standards, especially regarding students' perception of academic QoL. When HEIs understand and measure their IC, they will gain a better understanding of their core competencies, enabling a better allocation of resources and implementation of more effective strategic and operational actions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10734-020-00653-9.

A distributed heat transfer model for thermal-hydraulic analyses in sewer networks.

Thermal-hydraulic considerations in urban drainage networks are essential to utilise available heat capacities from waste- and stormwater. However, available models are either too detailed or too coarse; fully coupled thermal-hydrodynamic modelling tools are lacking. To predict efficiently water-energy dynamics across an entire urban drainage network, we suggest the SWMM-HEAT model, which extends the EPA-StormWater Management Model with a heat-balance component. This enables conducting more advanced thermal-hydrodynamic simulation at full network scale than currently possible. We demonstrate the usefulness of the approach by predicting temperature dynamics in two independent real-world cases under dry weather conditions. We furthermore screen the sensitivity of the model parameters to guide the choice of suitable parameters in future studies. Comparison with measurements suggest that the model predicts temperature dynamics adequately, with RSR values ranging between 0.71 and 1.1. The results of our study show that modelled in-sewer wastewater temperatures are particularly sensitive to soil and headspace temperature, and headspace humidity. Simulation runs are generally fast; a five-day period simulation at high temporal resolution of a network with 415 nodes during dry weather was completed in a few minutes. Future work should assess the performance of the model for different applications and perform a more comprehensive sensitivity analysis under more scenarios. To facilitate the efficient estimation of available heat budgets in sewer networks and the integration into urban planning, the SWMM-HEAT code is made publicly available.

Is flow control in a space-constrained drainage network effective? A performance assessment for combined sewer overflow reduction.

Recurring combined sewer overflows (CSOs) can have a significant impact on the ecological condition of receiving water bodies. There are several structural measures, like adding retention basins and switching to low impact development solutions, that have been proposed to reduce the number of sewage overflows. Besides, several flow control strategies have been discussed in scientific literature that take advantage of the space within urban drainage networks, which is assumed to be adequate, for temporary storage. The adequacy of such storage space, however, is not a universally valid assumption as a large fraction of drainage networks frequently operate close to their design discharge. In this paper, we investigate the efficacy of flow control for a space-constrained drainage network. We employ a low-cost, heuristic real time control strategy with the use of flow control devices (FCDs) and available in-sewer space to reduce the magnitude of CSOs. We consider the performance of the proposed control strategy and discuss the effect of FCD location on CSO reduction. Our results, based on over 300 rainfall-event simulations, show that the flow control strategy using limited sewer capacity is more efficient during relatively small rainfall events, where the CSO is large enough to enable reduction using the chosen control rules. The CSO is reduced, to varying degrees, for around 80% of rainfall events with peak intensity between 10 and 20 mm h-1. For larger rainfall events, the flow control is more unstable in response to abrupt water release during control operation, which seems to be unavoidable because of the water accumulation effect and the transition to pressurized pipe flow in space-constrained networks. We also found that the flow control performance is highly sensitive to the FCD location - as it depends on the interplay of the peak rainfall intensity and the water level condition immediately upstream of the FCD. The efficacy of a location for flow control is determined by the unfilled capacity (i.e., effective in-sewer storage potential) in the pipe upstream of the FCD during the rainfall peak; furthermore, the location also has to be resistant to the water accumulation effect. Using our analysis, we substantiate two anticipated caveats to flow control strategies when the storage space is limited in a drainage network: diminished performance in CSO reduction and the appearance of additional control-related challenges, which are otherwise mitigated in more spacious networks.

Quality of Work Life and Contribution to Productivity: Assessing the Moderator Effects of Burnout Syndrome.

This study is focused on assessing the effects of burnout as a moderator of the relationship between employees' quality of work life (QWL) and their perceptions of their contribution to the organization's productivity by integrating the QWL factors into the trichotomy of (de)motivators of productivity in the workplace. The empirical findings resulting from an OLS multiple regression, with interaction terms, applied to a survey administered at 514 employees in 6 European countries, point out two important insights: (i) QWL hygiene factors (e.g., safe work environment and occupational healthcare) positively and significantly influence the contribution to productivity; and (ii) burnout de-motivator factors (that is, low effectiveness, cynicism, and emotional exhaustion) significantly moderate the relationship between QWL and the contribution to productivity. Combining burnout with other QWL components, such as occupational health, safe work, and appropriate salary, new insights are provided concerning the restricting (i.e., low effectiveness and cynicism) and catalyzing (emotional exhaustion) burnout components of contribution to productivity. These findings are particularly relevant given the increased weight of burnout, mental disorders and absenteeism in the labor market, affecting individuals' quality of life and organizations' performance and costs.

Three-way calibration using PARAFAC and MCR-ALS with previous synchronization of second-order chromatographic data through a new functional alignment of pure vectors for the quantification in the presence of retention time shifts in peak position and shape.

In the present contribution is shown the application of the recently developed functional alignment of pure vectors (FAPV) as a proper algorithm to align second-order chromatographic data with severe retention time shifts in peak position and shape. FAPV decomposed a three-way chromatographic data array in their three modes (sample, spectral and elution time vectors), using a basis function to pre-process the non-linear mode (elution time) and then it aligns the functionalized pure vectors and reshapes the transformed vectors into matrices, restoring the trilinearity of second-order chromatographic data. The well-aligned three-way chromatographic data array is then successfully decomposed by advanced chemometric models such as parallel factor analysis (PARAFAC) and multivariate curve resolution - alternating least-squares (MCR-ALS) with the trilinearity constraint. The performance of this innovative analytical strategy based on PARAFAC and MCR-ALS with previous synchronization of data through FAPV algorithm is properly evaluated using real second-order chromatographic data with multiple artifacts, i.e., shifts in peak position and shape for the simultaneous quantification of amoxicillin and potassium clavulanate in commercial medicinal drugs. The present contribution compares some analytical results achieved by: (1) the usual MCR-ALS as a bilinear model applied in augmented data matrix without previous synchronization and with interval correlation optimized shifting (ICOSHIFT) and FAPV and (2) trilinear models using PARAFAC with ICOSHIFT and FAPV and trilinearity constraint in MCR-ALS with FAPV. Available results suggest that these strongly shifted and warped elution time profiles cause for the loss of trilinearity, which can be adequately restored by FAPV algorithm. PARAFAC performed a successful trilinear decomposition of three-way chromatographic data array with law values of relative prediction error (REP) in the order of 1.34-1.42% in both analytes.