Detecting Aggressive Papillary Thyroid Carcinoma Using Hyperspectral Imaging and Radiomic Features.

Hyperspectral imaging (HSI) and radiomics have the potential to improve the accuracy of tumor malignancy prediction and assessment. In this work, we extracted radiomic features of fresh surgical papillary thyroid carcinoma (PTC) specimen that were imaged with HSI. A total of 107 unique radiomic features were extracted. This study includes 72 ex-vivo tissue specimens from 44 patients with pathology-confirmed PTC. With the dilated hyperspectral images, the shape feature of least axis length was able to predict the tumor aggressiveness with a high accuracy. The HSI-based radiomic method may provide a useful tool to aid oncologists in determining tumors with intermediate to high risk and in clinical decision making.

CascadeNet for hysterectomy prediction in pregnant women due to placenta accreta spectrum.

In severe cases, placenta accreta spectrum (PAS) requires emergency hysterectomy, endangering the life of both mother and fetus. Early prediction may reduce complications and aid in management decisions in these high-risk pregnancies. In this work, we developed a novel convolutional network architecture to combine MRI volumes, radiomic features, and custom feature maps to predict PAS severe enough to result in hysterectomy after fetal delivery in pregnant women. We trained, optimized, and evaluated the networks using data from 241 patients, in groups of 157, 24, and 60 for training, validation, and testing, respectively. We found the network using all three paths produced the best performance, with an AUC of 87.8, accuracy 83.3%, sensitivity of 85.0, and specificity of 82.5. This deep learning algorithm, deployed in clinical settings, may identify women at risk before birth, resulting in improved patient outcomes.

Placenta Accreta Spectrum and Hysterectomy Prediction Using MRI Radiomic Features.

In women with placenta accreta spectrum (PAS), patient management may involve cesarean hysterectomy at delivery. Magnetic resonance imaging (MRI) has been used for further evaluation of PAS and surgical planning. This work tackles two prediction problems: predicting presence of PAS and predicting hysterectomy using MR images of pregnant patients. First, we extracted approximately 2,500 radiomic features from MR images with two regions of interest: the placenta and the uterus. In addition to analyzing two regions of interest, we dilated the placenta and uterus masks by 5, 10, 15, and 20 mm to gain insights from the myometrium, where the uterus and placenta overlap in the case of PAS. This study cohort includes 241 pregnant women. Of these women, 89 underwent hysterectomy while 152 did not; 141 with suspected PAS, and 100 without suspected PAS. We obtained an accuracy of 0.88 for predicting hysterectomy and an accuracy of 0.92 for classifying suspected PAS. The radiomic analysis tool is further validated, it can be useful for aiding clinicians in decision making on the care of pregnant women.

Deep Learning-Based Abdominal Muscle Segmentation on CT Images of Surgical Patient Populations.

Computed tomography (CT) is commonly used for the characterization and tracking of abdominal muscle mass in surgical patients for both pre-surgical outcome predictions and post-surgical monitoring of response to therapy. In order to accurately track changes of abdominal muscle mass, radiologists must manually segment CT slices of patients, a time-consuming task with potential for variability. In this work, we combined a fully convolutional neural network (CNN) with high levels of preprocessing to improve segmentation quality. We utilized a CNN based approach to remove patients' arms and fat from each slice and then applied a series of registrations with a diverse set of abdominal muscle segmentations to identify a best fit mask. Using this best fit mask, we were able to remove many parts of the abdominal cavity, such as the liver, kidneys, and intestines. This preprocessing was able to achieve a mean Dice similarity coefficient (DSC) of 0.53 on our validation set and 0.50 on our test set by only using traditional computer vision techniques and no artificial intelligence. The preprocessed images were then fed into a similar CNN previously presented in a hybrid computer vision-artificial intelligence approach and was able to achieve a mean DSC of 0.94 on testing data. The preprocessing and deep learning-based method is able to accurately segment and quantify abdominal muscle mass on CT images.