ABSTRACT
PURPOSE: To evaluate the antihypertensive effect of captopril in mild and moderate hypertensive patients uncontrolled with diuretics. METHODS: Low dose of captopril (25 to 50 mg) bid were associated during 9 weeks in 120 patients previously treated with 100 mg of hydrochlorothiazide. A subgroup of patients (74) were followed additionally for 3 weeks with the same dose of the drugs administered as a single dose. The patients were clinically evaluated after two weeks placebo, and each three weeks of active drugs. Blood pressure normalization were considered when diastolic arterial pressure was < or = 90 mmHg. Laboratory tests were measured before diuretic, before captopril and at the end of combined twelve weeks treatment. RESULTS: After 15 days washout, the baseline supine arterial pressure, 168 +/- 2/ 109 +/- 1 mmHg decrease significantly with diuretic to 151 +/- 1/ 101 +/- 1 mmHg and the drop was further increased with captopril b.i.d., with a mean dose of 44 +/- 1 mg, to 137 +/- 1/ 90 +/- 1 mmHg. Blood pressure normalization was obtained in 58% patients with captopril b.i.d. and in 63% as single dose. Blood pressure normalization was achieved in 63% of non-white patients and in 56% patients over 45 years old. Plasmatic potassium decreased significantly with diuretic and did not recovered when captopril was associated. CONCLUSION: Our results indicate that the addition of low dose of captopril twice or once a day may result in a marked additional blood pressure reduction in cases of insufficient control by the diuretic alone.
Subject(s)
Captopril/administration & dosage , Hydrochlorothiazide/therapeutic use , Hypertension/drug therapy , Adolescent , Adult , Aged , Blood Pressure/drug effects , Captopril/therapeutic use , Drug Resistance , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Potassium/bloodSubject(s)
Heart Arrest, Induced , Hypothermia, Induced , Mitochondria, Heart/enzymology , Myocardium/metabolism , Oxidoreductases/metabolism , Animals , Dogs , Glutamate Dehydrogenase/metabolism , Hydroxybutyrate Dehydrogenase/metabolism , Ketoglutarate Dehydrogenase Complex/metabolism , Malate Dehydrogenase/metabolism , Male , Succinate Dehydrogenase/metabolismABSTRACT
O uso de associacao gentamicina-cefalosporina em paciente portadora de carcinoma epidermoide de colo uterino, estadio IV e tratada pela cis-diaminodicloroplatina, foi complicado por uma insuficiencia renal aguda. A dose de gentamicina foi de 5 mg/kg/dia, via muscular e de cefalosporina de 70 mg/kg/dia, via venosa.A dose do cis-diaminodicloroplatina foi de 80 mg/m2, sendo utilizadas duas doses com intervalo de 21 dias. Apos 15 dias do inicio da aplicacao da gentamicina-cefalosporina, a paciente desenvolveu insuficiencia renal aguda, que precedeu o obito
Subject(s)
Gentamicins , Cephalosporins , Cisplatin , Acute Kidney InjuryABSTRACT
Foram estudados 24 caes distribuidos nos seguintes grupos: Grupo I - Oito animais, cujos coracoes foram estudados imediatamente apos anestesia e toratocomia (controle).Grupo II Oito animais submetidos a 60 minutos de parada cardiaca anoxica normotermica. Grupo III Oito animais submetidos a 60 minutos de parada cardiaca anoxica hipotermica (20 graus).Os resultados obtidos possibilitaram as seguintes conclusoes: A) O esfriamento seletivo do miocardio impediu a diminuicao das concentracoes de ATP. B) As alteracoes nos sistemas enzimaticos estudados (alfa-ceco-glutario-desidrogenase: succino-desidrogenase; beta-hidroxi-butirico-desidrogenase; glutamico-desidrogenase e malico-desidrogenase), determinadas pela parada anoxica normotermica, excetuando-se o controle da beta-hidroxi-butiricodesidrogenase, nao foram prevenidas pelo esfriamento do miocardio a 20 graus C
