Phytosterol supplementation in capsules or tablets as adjunctive treatment for hypercholesterolemia: A systematic review of randomized controlled trials.

BACKGROUND: The exploration of lipid-lowering resources, such as phytosterols, for the complementary nutritional treatment of hypercholesterolemia is relevant to reduce cardiovascular risk. The use of phytosterols in capsules or tablets can bring advantages in the context of diet therapy, but such format is still less studied when compared to fortified foods. OBJECTIVE: Systematically review randomized clinical trials on the effects of phytosterol supplementation, in capsules or tablets, on the lipid profile and its use in the treatment of hypercholesterolemia in adults. DESIGN: A systematic review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis, with a PROSPERO protocol registered under number CRD42021249539. The process was conducted by two independent reviewers. Only randomized clinical trials with phytosterol supplementation in adult individuals with hypercholesterolemia were included. The terms were searched in the databases: PubMed/MEDLINE, Cochrane Library/CENTRAL, Embase, LILACS and Web of Science, without restriction of time and language. The manual search was also performed through the list of references of articles included in this review. RESULTS: The searches resulted in 977 articles. 22 articles were selected, whose full text was read, and according to the eligibility criteria 10 were incorporated into the review. The studies were separated into groups according to the association of the intervention with changes in lifestyle and the characteristics extracted from the studies were summarized and displayed in tables. Most studies have revealed a positive association between phytosterol supplementation and cholesterol reduction, despite the short duration of interventions. CONCLUSION: The analyzed studies showed that phytosterol supplements can be useful to modulate the lipid profile, helping to reduce the plasma concentration of LDL cholesterol. However, more research with the aforementioned supplementation in such pharmaceutical formats should be encouraged.

The Effects of Workplace Stressors on Dietary Patterns among Workers at a Private Hospital in Recôncavo of Bahia, Brazil: A Longitudinal Study before and during the COVID-19 Pandemic.

Working in a hospital environment is known for presenting unhealthy features that affect the workers' health-features which have currently been intensified due to the COVID-19 pandemic. Hence, this longitudinal study aimed to ascertain the level of job stress before and during the COVID-19 pandemic, how this changed, and its association with the dietary patterns of hospital workers. Data on sociodemographic, occupational, lifestyle, health, anthropometric, dietetic, and occupational stress were collected before and during the pandemic from 218 workers at a private hospital in the Recôncavo of Bahia, Brazil. McNemar's chi-square test was used for comparison purposes, Exploratory Factor Analysis to identify dietary patterns, and Generalized Estimating Equations to evaluate the interested associations. During the pandemic, participants reported increased occupational stress, shift work, and weekly workloads, compared with before the pandemic. Additionally, three dietary patterns were identified before and during the pandemic. No association was observed between changes in occupational stress and dietary pattens. However, COVID-19 infection was related to changes in pattern A (0.647, IC95%0.044;1.241, p = 0.036) and the amount of shift work related to changes in pattern B, (0.612, IC95%0.016;1.207, p = 0.044). These findings support calls to strengthen labour policies to ensure adequate working conditions for hospital workers in the pandemic context.

PREVALENCE OF MALNUTRITION, ACCORDING TO THE GLIM CRITERIA, IN PATIENTS WHO ARE THE CANDIDATES FOR GASTROINTESTINAL TRACT SURGERY.

OBJECTIVE: Surgical patients constitute a group of individuals who are commonly underdiagnosed and undertreated, where nutritional impairment can be either a preexisting finding or a result of the hypercatabolic and hypermetabolic state. The purpose of this study was to assess the prevalence of malnutrition, according to the GLIM criteria, and its association with clinical and nutritional factors, in individuals admitted to a surgical unit of a general hospital. METHODS: A cross-sectional, retrospective study was conducted, involving patients in the preoperative period due to gastrointestinal diseases. Demographic, clinical, and nutritional data were collected from adult and elderly patients admitted to a surgical unit between March and December 2019. Nutritional risk was assessed using the Nutritional Risk Screening tool (NRS-2002). The prevalence of malnutrition was found using the GLIM criteria. Binary logistic regression modeling was performed to determine the association between the diagnosis of malnutrition using the GLIM method and clinical and nutritional variables. RESULTS: The majority of the sample presented nutritional risk (50.2%) according to the NRS-2002. The prevalence of malnutrition according to the GLIM criteria was 32.3%, with severe malnutrition being predominant (21.2%) in all age groups. There was an association between malnutrition and nutritional risk detected by the NRS-2002 (OR: 5.791; 95%CI 3.201-10.478). There was a predominance of patients undergoing cancer surgery (64%) and these patients were more likely to be diagnosed with malnutrition (OR: 2.068; 95%CI: 1.161-3.683), after statistical adjustment. CONCLUSION: An important prevalence of nutritional risk assessed by the NRS-2002 and of malnutrition assessed by the GLIM method was identified, especially in its severe form. In addition, preoperative patients with nutritional risk, as detected using the NRS-2002 nutritional screening tool, and candidates for oncologic surgery are more likely to be diagnosed as malnourished using the GLIM criteria.

Degree of food processing and association with overweight and abdominal obesity in adolescents.

OBJECTIVE: To evaluate the association between the degree of food processing, overweight, and abdominal obesity in adolescents. METHODS: This is a cross-sectional study, with 576 adolescents aged 10 to 17 years, of both sexes. Food consumption was collected using the Food Frequency Questionnaire and foods classified as in natura or minimally processed, processed foods associated with culinary ingredients, and ultraprocessed foods. Sociodemographic data, body mass index, waist circumference and waist-to-height ratio were collected. The analysis was evaluated by the Mann-Whitney test and prevalence ratio with 95% confidence interval, considering p<0.05. RESULTS: An intake above the third quartile of processed foods associated with culinary ingredients (prevalence ratio of 1.64; 95%CI: 1.12-2.42) and ultraprocessed (prevalence ratio of 1.58; 95%CI: 1.07-2.34) was associated with a higher prevalence of overweight. Consumption above the third quartile of ultraprocessed foods was associated with a higher prevalence of abdominal obesity, assessed by waist circumference (prevalence ratio of 2.48; 95%CI: 1.41-4.36), and waist-height ratio (prevalence ratio of 2.09; 95%CI: 1.11-3.92). CONCLUSION: A higher consumption of processed foods associated with culinary ingredients was related to being overweight, and ultraprocessed foods with overweight and abdominal obesity.

Prevalence of malnutrition, according to the glim criteria, in patients who are the candidates for gastrointestinal tract surgery / Prevalência de desnutrição, segundo critérios glim, em pacientes candidatos a cirurgias do trato gastrointestinal

ABSTRACT - BACKGROUND: Surgical patients constitute a group of individuals who are commonly underdiagnosed and undertreated, where nutritional impairment can be either a preexisting finding or a result of the hypercatabolic and hypermetabolic state. OBJECTIVE: The purpose of this study was to assess the prevalence of malnutrition, according to the GLIM criteria, and its association with clinical and nutritional factors, in individuals admitted to a surgical unit of a general hospital. METHODS: A cross-sectional, retrospective study was conducted, involving patients in the preoperative period due to gastrointestinal diseases. Demographic, clinical, and nutritional data were collected from adult and elderly patients admitted to a surgical unit between March and December 2019. Nutritional risk was assessed using the Nutritional Risk Screening tool (NRS-2002). The prevalence of malnutrition was found using the GLIM criteria. Binary logistic regression modeling was performed to determine the association between the diagnosis of malnutrition using the GLIM method and clinical and nutritional variables. RESULTS: The majority of the sample presented nutritional risk (50.2%) according to the NRS-2002. The prevalence of malnutrition according to the GLIM criteria was 32.3%, with severe malnutrition being predominant (21.2%) in all age groups. There was an association between malnutrition and nutritional risk detected by the NRS-2002 (OR: 5.791; 95%CI 3.201-10.478). There was a predominance of patients undergoing cancer surgery (64%) and these patients were more likely to be diagnosed with malnutrition (OR: 2.068; 95%CI: 1.161-3.683), after statistical adjustment. CONCLUSION: An important prevalence of nutritional risk assessed by the NRS-2002 and of malnutrition assessed by the GLIM method was identified, especially in its severe form. In addition, preoperative patients with nutritional risk, as detected using the NRS-2002 nutritional screening tool, and candidates for oncologic surgery are more likely to be diagnosed as malnourished using the GLIM criteria.

RESUMO - RACIONAL: Os pacientes cirúrgicos constituem um grupo de indivíduos comumente subdiagnosticado e subtratado, onde o comprometimento nutricional pode ser tanto um achado preexistente quanto decorrente do estado hipercatabólico e hipermetabólico. OBJETIVO: Avaliar a prevalência de desnutrição, de acordo com os critérios GLIM (Global Leadership Initiative on Malnutrition), e sua associação com fatores clínicos e nutricionais, em indivíduos internados em uma unidade cirúrgica de um hospital geral. MÉTODOS: Estudo transversal, retrospectivo, envolvendo pacientes no pré-operatório por doenças gastrointestinais. Foram coletados dados demográficos, clínicos e nutricionais de pacientes adultos e idosos admitidos entre março e dezembro de 2019 em uma unidade cirúrgica. O risco nutricional foi avaliado pela ferramenta Nutritional Risk Screening (NRS 2002). A prevalência de desnutrição foi encontrada a partir dos critérios GLIM. Modelos de regressão logística binária foram realizados para determinar a associação entre o diagnóstico de desnutrição pelo método GLIM e variáveis clínicas e nutricionais. RESULTADOS: A maior parte da amostra apresentou risco nutricional (50,2%) conforme NRS 2002. A prevalência de desnutrição pelos critérios GLIM foi 32,3%, sendo a desnutrição grave predominante (21,2%) em todas as faixas etárias. Verificou-se associação entre a desnutrição e o risco nutricional detectado pela NRS-2002 (OR: 5,791; IC5% 3,201-10,478). Observou-se predominância de pacientes candidatos a cirurgias oncológicas (64%) e estes apresentaram maiores chances de receber o diagnóstico de desnutrição (OR: 2,068; IC95%: 1,161-3,683), após ajuste estatístico. CONCLUSÃO: Foi Identificado importante prevalência de risco nutricional avaliado pela NRS-2002 e de desnutrição pelo método GLIM, principalmente na forma grave. Além disso, os pacientes no pré-operatório com risco nutricional, detectado por meio da ferramenta de triagem nutricional NRS 2002, e aqueles candidatos à cirurgia oncológica têm mais chances de serem diagnosticados como desnutridos pelos critérios GLIM.

Degree of food processing and association with overweight and abdominal obesity in adolescents

ABSTRACT Objective To evaluate the association between the degree of food processing, overweight, and abdominal obesity in adolescents. Methods This is a cross-sectional study, with 576 adolescents aged 10 to 17 years, of both sexes. Food consumption was collected using the Food Frequency Questionnaire and foods classified as in natura or minimally processed, processed foods associated with culinary ingredients, and ultraprocessed foods. Sociodemographic data, body mass index, waist circumference and waist-to-height ratio were collected. The analysis was evaluated by the Mann-Whitney test and prevalence ratio with 95% confidence interval, considering p<0.05. Results An intake above the third quartile of processed foods associated with culinary ingredients (prevalence ratio of 1.64; 95%CI: 1.12-2.42) and ultraprocessed (prevalence ratio of 1.58; 95%CI: 1.07-2.34) was associated with a higher prevalence of overweight. Consumption above the third quartile of ultraprocessed foods was associated with a higher prevalence of abdominal obesity, assessed by waist circumference (prevalence ratio of 2.48; 95%CI: 1.41-4.36), and waist-height ratio (prevalence ratio of 2.09; 95%CI: 1.11-3.92). Conclusion A higher consumption of processed foods associated with culinary ingredients was related to being overweight, and ultraprocessed foods with overweight and abdominal obesity.

Occupational Risks in Hospitals, Quality of Life, and Quality of Work Life: A Systematic Review.

This study systematically reviewed the relationship between occupational risks and quality of life (QoL) and quality of work life (QWL) in hospitals. A systematic review was performed according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide, and the protocol was submitted on the PROSPERO website (CRD 2019127865). The last search was performed in June 2021 by two independent reviewers in the main databases, a gray literature database, and a manual search (LILACS, MEDLINE/PubMed, PsycINFO, CINAHL, Scopus, Embase, Brazilian Digital Library of Theses and Dissertations, Ovid). As eligibility criteria, we included observational studies, with adult hospital workers, with no restrictions on date and language, any type of instrument to assess QoL and QWL, any definition of QoL and QWL, and studies that presented the relationship between exposure and outcome. Newcastle-Ottawa was used to assess the methodological quality and RTI-Item Bank to assess the risk of bias. Given the impossibility of performing a meta-analysis, a qualitative synthesis was used to present the results. Thus, 11 studies met the criteria and were included in the review, with 6923 individuals aged 18 to 64 years. The studies were mainly carried out with health professionals (81.81%), women (63.60%), and in Asian countries (63.63%). All studies used different instruments and ways to categorize the QoL and QWL, and occupational risks. Only one study assessed occupational noise and another the ergonomic risk. All of them presented a relationship between occupational risk and quality of work life. They pointed to the need for measures to improve the lives of these professionals in the work environment. Therefore, studies show a relationship between occupational risks (noise, ergonomics, and stress) and workers' perception of low or moderate quality of work life. However, more homogeneous studies are necessary for instruments, conceptualization, and categorization of quality of work life.

Association between migraine, constipation and lactose intolerance in adults patients / Associação entre enxaqueca, constipação intestinal e intolerância à lactose em adultos

ABSTRACT BACKGROUND AND OBJECTIVES: Considering the bidirectional connection between intestine and brain, the present study examined the association between migraine, lactose intolerance, and intestinal constipation in patients with status migrainosus. METHODS: This is a cross-sectional retrospective study that included 97 patients aged 20 years or older. The impact of pain was assessed by the Migraine Disability Assessment and the Headache Impact Test-6 questionnaires. The pain intensity was measured by the visual analog scale. Chi-square and Student-t tests were used for the statistical analysis. RESULTS: The sample consisted of 88.7% women, 56.8% overweight, 76.3% sedentary, 32% constipated and 23.7% lactose intolerant. Higher pain intensity (8.9±1.3) and impact pain mean was assessed by the Headache Impact Test-6 (67.6±5.3) and the Migraine Disability Assessment (36.7±26.3) in constipated patients compared to those without constipation. Lactose-intolerant patients presented higher migraine mean time (19.9±14.2) compared to lactose tolerant patients. Constipated and lactose intolerant patients presented higher prevalence of overweight (58.1 and 65.2%) and abdominal obesity (70.0 and 68.2%) compared to non-constipated and lactose tolerant patients, respectively. CONCLUSION: Although were observed in the evaluated sample a considerable prevalence of constipation and lactose intolerance, higher mean scores in the questionnaires used for pain impact and intensity in constipated patients and longer migraine diagnosis time in those with lactose-intolerance, there was no statistical significance in the association between migraine and these two gastrointestinal disorders.

RESUMO JUSTIFICATIVA E OBJETIVOS: Ao considerar a conexão bidirecional entre intestino e cérebro, o presente estudo avaliou a associação entre enxaqueca, intolerância à lactose e constipação intestinal em pacientes em estado migranoso. MÉTODOS: Trata-se de um estudo transversal e retrospectivo que incluiu 97 pacientes com idade igual ou superior a 20 anos. O impacto da dor foi avaliado pelos questionários: Migraine Disability Assessment e Headache Impact Test-6. A intensidade da dor foi avaliada pela escala analógica visual. Os testes Qui-quadrado e Student-t foram utilizados para análise estatística. RESULTADOS: A amostra foi composta por 88,7% de mulheres, 56,8% com excesso de peso, 76,3% sedentários, 32% constipados e 23,7% intolerantes à lactose. Os constipados apresentaram maiores médias de impacto da dor pelo Headache Impact Test-6 (67,6±5,3) e pelo Migraine Disability Assessment (36,7±26,3) e intensidade da dor (8,9±1,3) do que os não constipados. Os pacientes intolerantes à lactose apresentaram maior média de tempo de enxaqueca (19,9±14,2) em relação aos tolerantes à lactose. Os pacientes constipados apresentaram maiores prevalências de excesso de peso (58,1 e 65,2%) e obesidade abdominal (70,0 e 68,2%) e intolerantes em relação aos sem constipação intestinal e aos tolerantes à lactose, respectivamente. CONCLUSÃO: Embora identificadas prevalências consideráveis de constipação intestinal e intolerância à lactose na amostra avaliada, além de maiores médias de pontuação nos questionários utilizados para impacto e intensidade da dor nos pacientes constipados e de maior tempo de diagnóstico da migrânea nos intolerantes à lactose, não houve significância estatística na associação entre enxaqueca e esses distúrbios gastrointestinais.

Anthropometric status and lipid profile among children and adolescents: Changes after 18-month follow-up.

BACKGROUND & AIMS: Overweight children and adolescents are more likely to evolve with high cholesterol, be obese adults and develop cardiovascular disease. The objective of this study was to identify the influence of anthropometric status on the changes in the lipid profile of children and adolescents during an 18-month follow-up period. METHODS: A cohort study involving 540 boys and girls from 7 to 15 years of age was conducted over 18 months' follow-up. The outcome variables were the lipid indicators and the principal exposure variable was anthropometric status, measured by different indicators. A generalized estimating equation (GEE) approach was used to identify the associations of interest. RESULTS: Irrespective of age, sex, socio-economic status, physical activity and diet, for each gain of 1 cm in the waist circumference (WC) mean in the adjusted model, triglyceride levels increased by a mean of 0.5 mg/dl (p < 0.000) and there was an increase of 0.21 mg/dL in the total cholesterol after the 18-month period. The increase of 0.1 in the mean body mass index (BMI) Z-score promoted a gain of 2.7 mg/dL in the triglycerides mean levels (p < 0.000) and an increase of 1.5 mg/dL in the total cholesterol mean levels (p = 0.014) after the follow-up period. Regarding the waist-to-height ratio (WHtR) and conicity index (CI), an increment of 40.6 mg/dL (p = 0.02) and of 30.1 mg/dL (p = 0.01) was observed in the triglycerides' mean when the participants increased 0.1 in the WHtR mean and CI mean, and the same was observed in the total cholesterol mean, with an increase of 45.4,g/dL (p = 0.02) and 19.3 mg/dL (p = 0.03), for each indicator, respectively. Changes of the traditional anthropometric indicators (WC and BMI) did not promote variations in the mean levels of LDL-cholesterol. HDL-cholesterol was not influenced by the changes in the anthropometric indicators. CONCLUSIONS: At the baseline, a higher triglyceride mean and lower levels of HDL-c were observed in children and adolescents with altered anthropometric status for all measures. Mean triglyceride and total cholesterol levels are influenced by changes in the anthropometric status, regardless of the measure, after 18 months of follow-up. However, for LDL-cholesterol, it was observed that changes in the traditional anthropometric indicators (WC and BMI) did not promote variations in the mean levels of this biochemical variable, while HDL-c was not influenced by changes in any of the anthropometric indicators.

Risco nutricional pelo método Nutritional Risk Screening - 2002 de pacientes no pré-operatório em um hospital geral público da cidade de Salvador-BA / Nutritional risk by Method Nutritional Risk Screening - 2002 of patients in preoperative in a public hospital In Salvador city - Bahia

Introdução: A desnutrição é um fator de risco de complicações pós-operatórias. Assim, este estudo objetiva identificar o risco nutricional, com o uso de um método de triagem nutricional, de pacientes internados em enfermaria cirúrgica no pré-operatório, em um hospital geral público, da cidade do Salvador, BA. Método: Estudo transversal. Foram coletados dados dos pacientes admitidos, no período de março a julho de 2013, referentes ao sexo, idade, diagnóstico cirúrgico, peso, altura e classificação do Nutritional Risk Screening - 2002. Utilizou-se o índice de massa corporal para determinar a prevalência de desnutrição conforme estratificação proposta pela Organização Mundial da Saúde, para adultos, e a proposta por Lipschitz, para idosos. Usou-se o software Statistical Package for Social Sciences versão 17.0.0 para análises estatísticas e o teste Qui-Quadrado, sendo significante quando p<0,05. Resultados: Foram incluídos 180 pacientes, idade média de 53±16,00 anos, sendo a maioria (58,9%) do gênero feminino e 28,9% desnutridos. A prevalência geral de risco nutricional foi de 46,1%. O sexo masculino apresentou maior prevalência de risco nutricional (62,2%), assim como os idosos (50,8%) e os pacientes oncológicos (71,3%) (p<0,001 entre os grupos). Conclusões: Não foi detectada prevalência de desnutrição. O risco nutricional foi prevalente em aproximadamente metade da amostra. Estiveram relacionados ao maior risco nutricional: gênero masculino, idade avançada e cirurgias oncológicas. Os dados encontrados confirmam a necessidade de investigação da condição nutricional no pré-operatório, colaborando para intervenção nutricional adequada, melhores desfechos clínicos e redução dos custos hospitalares.(AU)

Introduction: Malnutrition is a risk factor complications postoperative. Thus, this study aims to identify nutritional risk according to a nutritional screening method, of patients admitted to surgical ward in the preoperative period, in a general hospital in the city of Salvador, BA. Methods: This is a cross-sectional study. Data were collected from patients admitted, during the period from March to July 2013, on gender, age, surgical diagnosis, anthropometric measures (weight and height) and classification Nutritional Risk Screening - 2002. Body Mass Index was used to determine the prevalence of malnutrition as stratification proposed by the World Health Organization for adults and the proposal by Lipschitz for the elderly. Statistics analyses were performed with the aid of the software Statistical Package for Social Sciences (SPSS), version 17.0, using the Chi Square test. Statistical significance is reported for p<0.05. Results: The study included 180 patients, with a mean age of 53.0±16.0 years, the majority (58.9%) was female and 28.9% malnourished. The general prevalence of nutritional risk was 46.1%. Males had greater prevalence of nutritional risk (62.2%), as well as elderly (50.8%) and cancer patients (71.3%) (p<0.001 among groups). Conclusions: Prevalence of malnutrition was not detected. Nutritional risk was prevalent in approximately half of the studied sample. Related to higher nutritional risk were males, aging and cancer surgery. The data found confirm the need to research the nutritional status in the preoperative period, contributing to appropriate nutritional intervention, improved clinical outcomes and reduce hospital costs.(AU)