ABSTRACT
OBJECTIVE: Evaluation of haemodynamic effects after sublingual administration of 25 mg of captopril in patients with Acute Anterior Myocardial Infarction within the first 48 hours. DESIGN: Determination of basal parameters and 30 minutes after 25 mg of captopril. SETTING: Patients admitted in the ICU with Anterior Myocardial Infarction diagnosis. PATIENTS: 41 consecutive patients; 22 patients submitted to thrombolysis with streptokinase; 19 patients submitted to conventional therapy. RESULTS: A) In the whole group: No significant change in the HR, PAP, CI, SI, MAP, SVR, PR. RA and CWP were reduced. B) In thrombolysed patients: No significant change in HR, RA, PAP, CWP, MAP, SVR, PR. CI and SI were significantly increased. C) In non-thrombolysed patients: No significant change in HR, PAP, CI, SI, SVR, PR. RA, CWP and MAP were reduced. CONCLUSION: 1. We found no significant hypotension with sublingual captopril in Acute Myocardial Infarction. 2. Non-thrombolysed patients showed a greater reduction of arterial pressure. 3. Thrombolysed patients had significant increases in systolic function indices.
Subject(s)
Captopril/therapeutic use , Hemodynamics/drug effects , Myocardial Infarction/physiopathology , Administration, Sublingual , Aged , Female , Humans , Male , Middle Aged , Myocardial Infarction/drug therapyABSTRACT
Systolic time intervals and heart sounds were studied in twenty patients with left bundle branch block. A definite cause for the organic heart disease was not ascertained. Abnormal duration of the electromechanical systole (Q-A2), due to a prolongation both of the preejection period (PEP) and of the Q-M1 intervals, was found to exist in all. Prolongation of Q-M1 was due to lengthening either of the electromechanical interval (EMI) or of the pre-isovolumetric contraction time (PICT). Isovolumetric contraction time (ICT) was prolonged in thirteen patients only. There was a good correlation between LVET/ICT ratio and the duration of ICT intervals. Six patients showed a first heart sound of normal intensity and duration. There was no correlation between the duration of the systolic time intervals and the characteristics of the first and second heart sounds.
