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Behav Brain Res ; 222(1): 206-11, 2011 Sep 12.
Article in English | MEDLINE | ID: mdl-21459118

ABSTRACT

Depression and anxiety disorders present several genetic and neurobiological similarities. Drugs with antidepressant activity are effective in the treatment of a wide spectrum of anxiety disorders. Preclinical results showed that acute and chronic treatment with the NOP antagonist [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) produced antidepressant-like effects in rodents. Thus, the present study aimed to investigate the effect of central administration of UFP-101 on the anxiety-related behavior in rats as evaluated in the elevated T-maze (ETM) test. Our results showed that UFP-101 reduced the latency of inhibitory avoidance in the ETM, indicating an anxiolytic-like effect. The endogenous peptide N/OFQ prevented this anxiolytic-like action of UFP-101, demonstrating its modulation via central NOP receptors. However, UFP-101 failed to interfere with the latency to escape. No change was observed in locomotor activity after UFP-101 treatment, ruling out any nonspecific motor effect. In conclusion, our results showed that the central administration of UFP-101 presents an anxiolytic-like effect in rats evaluated in the ETM test, providing new insights for drug development to treat anxiety disorders targeting the N/OFQ-NOP receptor system.


Subject(s)
Anti-Anxiety Agents/administration & dosage , Anxiety/drug therapy , Maze Learning/drug effects , Analysis of Variance , Animals , Anxiety/physiopathology , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Interactions , Exploratory Behavior/drug effects , Male , Narcotic Antagonists , Opioid Peptides , Rats , Rats, Wistar , Receptors, Opioid/agonists , Nociceptin Receptor
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